DYRK3

Protein-coding gene in the species Homo sapiens
DYRK3
Identifiers
AliasesDYRK3, DYRK5, RED, REDK, hYAK3-2, dual specificity tyrosine phosphorylation regulated kinase 3
External IDsOMIM: 603497 MGI: 1330300 HomoloGene: 55762 GeneCards: DYRK3
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for DYRK3
Genomic location for DYRK3
Band1q32.1Start206,635,536 bp[1]
End206,684,419 bp[1]
Gene location (Mouse)
Chromosome 1 (mouse)
Chr.Chromosome 1 (mouse)[2]
Chromosome 1 (mouse)
Genomic location for DYRK3
Genomic location for DYRK3
Band1|1 E4Start131,055,192 bp[2]
End131,066,077 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • sperm

  • vena cava

  • stromal cell of endometrium

  • mucosa of urinary bladder

  • left ventricle

  • gallbladder

  • lactiferous duct

  • smooth muscle tissue

  • embryo

  • gastric mucosa
Top expressed in
  • seminiferous tubule

  • spermatid

  • spermatocyte

  • respiratory epithelium

  • olfactory epithelium

  • parotid gland

  • facial motor nucleus

  • bone marrow

  • endocardial cushion

  • Region I of hippocampus proper
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • transferase activity
  • protein kinase activity
  • protein serine/threonine/tyrosine kinase activity
  • protein tyrosine kinase activity
  • nucleotide binding
  • ATP binding
  • magnesium ion binding
  • metal ion binding
  • kinase activity
  • protein serine/threonine kinase activity
Cellular component
  • nucleus
  • nucleoplasm
  • cytosol
  • intracellular membrane-bounded organelle
  • cytoplasm
  • cytoplasmic stress granule
  • pericentriolar material
  • microtubule organizing center
  • cytoskeleton
  • nuclear speck
Biological process
  • erythrocyte differentiation
  • protein phosphorylation
  • peptidyl-tyrosine phosphorylation
  • phosphorylation
  • stress granule disassembly
  • negative regulation of apoptotic process
  • negative regulation of DNA damage response, signal transduction by p53 class mediator
  • regulation of cellular response to stress
  • regulation of TORC1 signaling
  • cell cycle
  • nuclear speck organization
  • cell division
  • positive regulation of cell cycle G2/M phase transition
  • organelle disassembly
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

8444

226419

Ensembl

ENSG00000143479

ENSMUSG00000016526

UniProt

O43781

Q922Y0

RefSeq (mRNA)

NM_001004023
NM_003582

NM_145508

RefSeq (protein)

NP_001004023
NP_003573

NP_663483

Location (UCSC)Chr 1: 206.64 – 206.68 MbChr 1: 131.06 – 131.07 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Dual specificity tyrosine-phosphorylation-regulated kinase 3 is an enzyme that in humans is encoded by the DYRK3 gene.[5][6]

This gene product belongs to the DYRK family of dual-specificity protein kinases that catalyze autophosphorylation on serine/threonine and tyrosine residues. The members of this family share structural similarity, however, differ in their substrate specificity, suggesting their involvement in different cellular functions. The encoded protein has been shown to autophosphorylate on tyrosine residue and catalyze phosphorylation of histones H3 and H2B in vitro. Alternatively spliced transcript variants encoding different isoforms have been identified.[6]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000143479 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000016526 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Becker W, Weber Y, Wetzel K, Eirmbter K, Tejedor FJ, Joost HG (Nov 1998). "Sequence characteristics, subcellular localization, and substrate specificity of DYRK-related kinases, a novel family of dual specificity protein kinases". J Biol Chem. 273 (40): 25893–902. doi:10.1074/jbc.273.40.25893. PMID 9748265.
  6. ^ a b "Entrez Gene: DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3".

Further reading

  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
  • Zhang D, Li K, Erickson-Miller CL, et al. (2005). "DYRK gene structure and erythroid-restricted features of DYRK3 gene expression". Genomics. 85 (1): 117–30. doi:10.1016/j.ygeno.2004.08.021. PMID 15607427.
  • Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455. S2CID 7200157.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Li K, Zhao S, Karur V, Wojchowski DM (2003). "DYRK3 activation, engagement of protein kinase A/cAMP response element-binding protein, and modulation of progenitor cell survival". J. Biol. Chem. 277 (49): 47052–60. doi:10.1074/jbc.M205374200. PMID 12356771.
  • Lord KA, Creasy CL, King AG, et al. (2000). "REDK, a novel human regulatory erythroid kinase". Blood. 95 (9): 2838–46. doi:10.1182/blood.V95.9.2838.009k29_2838_2846. PMID 10779429.
  • Xia J, Yang X, Ruan Q, et al. (1999). "[Molecular cloning and characterization of novel protein kinase gene DYRK3]". Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 15 (6): 327–32. PMID 9845759.


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