Decoglurant
Chemical compound
- none
- Development terminated
- 5-({7-(Trifluoromethyl)-5-[4-(trifluoromethyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl}ethynyl)-2-pyridinamine
- 911115-16-7
- 71533696
- 32695160
- 5VX4P0JKC5
- D10875
- Interactive image
- C1=CC(=CC=C1C2=NC3=C(C=NN3C(=C2)C(F)(F)F)C#CC4=CN=C(C=C4)N)C(F)(F)F
InChI
- InChI=1S/C21H11F6N5/c22-20(23,24)15-6-4-13(5-7-15)16-9-17(21(25,26)27)32-19(31-16)14(11-30-32)3-1-12-2-8-18(28)29-10-12/h2,4-11H,(H2,28,29)
- Key:DMJHZVARRXJSEG-UHFFFAOYSA-N
Decoglurant (INN) (code name RG1578, RO4995819) is a negative allosteric modulator of the mGlu2 and mGlu3 receptors which was under development by Roche for the adjunctive treatment of major depressive disorder.[1][2] Decoglurant progressed as far as phase II clinical trials[1][2] but was ultimately discontinued from further development due to disappointing efficacy results.[3][4]
See also
- Basimglurant
- RO4491533
References
- ^ a b "Roche – Pipeline". 2014. Archived from the original on 2022-10-23. Retrieved 2014-08-01.
- ^ a b "Roche Group Development Pipeline" (PDF). 2014. Archived from the original (PDF) on 2014-08-08. Retrieved 2014-08-01.
- ^ "Roche – Pipeline" (PDF). 2015. Archived from the original (PDF) on 2015-05-01. Retrieved 2015-05-14.
- ^ Lawrence J (March 2015). "The Secret Life of ketamine". The Pharmaceutical Journal. 294 (7854/5).
External links
- Decoglurant – AdisInsight – Springer
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mGluR1Tooltip Metabotropic glutamate receptor 1 |
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mGluR5Tooltip Metabotropic glutamate receptor 5 |
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mGluR2Tooltip Metabotropic glutamate receptor 2 |
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mGluR3Tooltip Metabotropic glutamate receptor 3 |
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mGluR4Tooltip Metabotropic glutamate receptor 4 |
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mGluR6Tooltip Metabotropic glutamate receptor 6 |
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mGluR7Tooltip Metabotropic glutamate receptor 7 | |
mGluR8Tooltip Metabotropic glutamate receptor 8 |
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See also: Receptor/signaling modulators • Ionotropic glutamate receptor modulators • Glutamate metabolism/transport modulators
This drug article relating to the nervous system is a stub. You can help Wikipedia by expanding it. |
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