Dihydrokainic acid
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IUPAC name (3S,4R)-3-(Carboxymethyl)-4-isopropyl-L-proline | |
Systematic IUPAC name (2S,3S,4R)-3-(2-Hydroxy-2-oxoethyl)-4-(propan-2-yl)pyrrolidine-2-carboxylic acid | |
Other names Dihydrokainate; DHK | |
Identifiers | |
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3D model (JSmol) |
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Beilstein Reference | 84942 |
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InChI
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Properties | |
Chemical formula | C10H17NO4 |
Molar mass | 215.249 g·mol−1 |
Hazards | |
GHS labelling: | |
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Warning | |
Hazard statements | H302, H312, H332 |
Precautionary statements | P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P312, P304+P340, P312, P322, P330, P363, P501 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references |
Chemical compound
Dihydrokainic acid is an organic compound that contains two carboxylic acid functional groups, making it a dicarboxylic acid. It is an inhibitor of the GLT-1 glutamate transporter.[1]
See also
References
- ^ Kawahara, K; Hosoya, R; Sato, H; Tanaka, M; Nakajima, T; Iwabuchi, S (2002). "Selective blockade of astrocytic glutamate transporter GLT-1 with dihydrokainate prevents neuronal death during ouabain treatment of astrocyte/neuron cocultures". Glia. 40 (3): 337–49. doi:10.1002/glia.10133. hdl:2115/5937. PMID 12420313. S2CID 14246291.
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EAATsTooltip Excitatory amino acid transporters |
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vGluTsTooltip Vesicular glutamate transporters |
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GAHTooltip Glutamine aminohydrolase (glutaminase) |
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ASTTooltip Aspartate aminotransferase |
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ALTTooltip Alanine aminotransferase |
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GDHTooltip Glutamate dehydrogenase |
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GSTooltip Glutamine synthetase | |
GADTooltip Glutamate decarboxylase |
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See also: Receptor/signaling modulators • Ionotropic glutamate receptor modulators • Metabotropic glutamate receptor modulators • GABA metabolism and transport modulators
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