Dihydroquinidine
Names | |
---|---|
IUPAC name (S)-[(2R,4S,5R)-5-ethyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxyquinolin-4-yl)methanol | |
Other names (9S)-10,11-Dihydro-6'-methoxycinchonan-9-ol | |
Identifiers | |
CAS Number |
|
3D model (JSmol) |
|
ChEMBL |
|
ChemSpider |
|
ECHA InfoCard | 100.007.578 |
PubChem CID |
|
UNII |
|
InChI
| |
| |
Properties | |
Chemical formula | C20H26N2O2 |
Molar mass | 326.440 g·mol−1 |
Melting point | 169 to 172 °C (336 to 342 °F; 442 to 445 K) |
Pharmacology | |
C01BA13 (WHO) | |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). N verify (what is YN ?) Infobox references |
Chemical compound
Dihydroquinidine (also called hydroquinidine) is an organic compound, a cinchona alkaloid closely related to quinine. The specific rotation is +226° in ethanol at 2 g/100 ml. A derivative of this molecule is used as chiral ligand in the AD-mix for Sharpless dihydroxylation.
The substance is also a class Ia antiarrhythmic medication.[1]
See also
References
- v
- t
- e
class I (Na+ channel blockers) |
| ||||||
---|---|---|---|---|---|---|---|
class III (Phase 3→, K+ channel blockers) | |||||||
class IV (Phase 4→, Ca2+ channel blockers) |
and antagonists
class II (Phase 4→, β blockers) |
|
---|---|
A1 agonist | |
M2 | |
α receptors |
Na+/ K+-ATPase |
---|
- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III