Ditolylguanidine
Experimental drug
- none
- 1,2-bis(2-methylphenyl)guanidine
- 97-39-2 Y
- 7333
- 6684
- 7056 Y
- LL2P01I17O
- ChEMBL282433 Y
- DTXSID2026606
- Interactive image
- N(=C(/Nc1ccccc1C)N)\c2ccccc2C
InChI
- InChI=1S/C15H17N3/c1-11-7-3-5-9-13(11)17-15(16)18-14-10-6-4-8-12(14)2/h3-10H,1-2H3,(H3,16,17,18) Y
- Key:OPNUROKCUBTKLF-UHFFFAOYSA-N Y
Ditolylguanidine is a sigma receptor agonist.[1] It is somewhat[2] selective for sigma receptors, but non-selective between the two sigma receptor subtypes, binding to both σ1 and σ2 with equal affinity.[3] It has neuroprotective[4] and antidepressant effects,[5] and potentiates the effects of NMDA antagonists.[6]
See also
- Aptiganel
References
- ^ Weber E, Sonders M, Quarum M, McLean S, Pou S, Keana JF (November 1986). "1,3-Di(2-[5-3H]tolyl)guanidine: a selective ligand that labels sigma-type receptors for psychotomimetic opiates and antipsychotic drugs". Proceedings of the National Academy of Sciences of the United States of America. 83 (22): 8784–8788. Bibcode:1986PNAS...83.8784W. doi:10.1073/pnas.83.22.8784. PMC 387016. PMID 2877462.
- ^ "1,3-Di-o-tolylguanidine | C15H17N3". PubChem. U.S. National Library of Medicine. Archived from the original on 2021-01-08. Retrieved 2017-06-07.
- ^ Glennon RA (October 2005). "Pharmacophore identification for sigma-1 (sigma1) receptor binding: application of the "deconstruction-reconstruction-elaboration" approach". Mini Reviews in Medicinal Chemistry. 5 (10): 927–940. doi:10.2174/138955705774329519. PMID 16250835.
- ^ Katnik C, Guerrero WR, Pennypacker KR, Herrera Y, Cuevas J (December 2006). "Sigma-1 receptor activation prevents intracellular calcium dysregulation in cortical neurons during in vitro ischemia". The Journal of Pharmacology and Experimental Therapeutics. 319 (3): 1355–1365. doi:10.1124/jpet.106.107557. PMID 16988055. S2CID 14582181.
- ^ Skuza G, Rogóz Z (2003). "Sigma1 receptor antagonists attenuate antidepressant-like effect induced by co-administration of 1,3 di-o-tolylguanidine (DTG) and memantine in the forced swimming test in rats". Polish Journal of Pharmacology. 55 (6): 1149–1152. PMID 14730114.
- ^ Monnet FP, Morin-Surun MP, Leger J, Combettes L (November 2003). "Protein kinase C-dependent potentiation of intracellular calcium influx by sigma1 receptor agonists in rat hippocampal neurons". The Journal of Pharmacology and Experimental Therapeutics. 307 (2): 705–712. doi:10.1124/jpet.103.053447. PMID 12975497. S2CID 35397107.
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Sigma receptor modulators
- Agonists: 3-PPP
- 4-PPBP
- 5-MeO-DMT
- Alazocine (SKF-10047)
- Amantadine
- Arketamine
- BD-737
- BD-1052
- Blarcamesine
- Captodiame
- Citalopram
- CGRPTooltip Calcitonin gene-related peptide
- Cloperastine
- Cocaine
- Cutamesine (SA-4503)
- Cyclazocine
- Dehydroepiandrosterone (DHEA) (prasterone)
- Dehydroepiandrosterone sulfate (DHEA-S) (prasterone sulfate)
- Dextrallorphan
- Dextromethorphan (DXM)
- Dextrorphan (DXO)
- Dimemorfan
- Dimethyltryptamine (DMT)
- Ditolylguanidine (DTG)
- Donepezil
- Eliprodil
- Escitalopram
- Fabomotizole (afobazole)
- Fluoxetine
- Fluvoxamine
- Ifenprodil
- Igmesine (JO-1784)
- IPAB
- Ketamine
- L-687384
- MDMA (midomafetamine)
- Memantine
- Methamphetamine
- Methoxetamine
- Methylphenidate
- Nepinalone
- Neuropeptide Y
- Noscapine
- OPC-14523
- Opipramol
- Pentazocine
- Pentoxyverine (carbetapentane)
- PRE-084
- Pregnenolone
- Pregnenolone sulfate
- Pridopidine
- Racemethorphan (methorphan)
- Racemorphan (morphanol)
- UMB-23
- UMB-82
- Antagonists: 3-PPP
- AC-927
- BD-1008
- BD-1031
- BD-1047
- BD-1060
- BD-1063
- BD-1067
- BMY-14802 (BMS-181100)
- CM-156
- Dup-734
- E-5842
- E-52862 (S1RA)
- Haloperidol
- LR-132
- LR-172
- MS-377
- NE-100
- NPC-16377
- Panamesine (EMD-57455)
- PD-144418
- Pentazocine
- Progesterone
- Rimcazole (BW-234U)
- Sertraline
- SR-31742A
- Allosteric modulators: Phenytoin; Positive: Methylphenylpiracetam
- SOMCL-668
- Unknown/unsorted: 3-Methoxydextrallorphan
- 3-MeO-PCP
- 4C-T-2
- 4-IBP
- 4-IPBS
- 4-MeO-PCP
- 5-MeO-DALT
- 5-MeO-DiPT
- Amitriptyline
- Azidopamil
- Chlorpromazine
- Clemastine
- Clomipramine
- Clorgiline
- D-Deprenyl
- DiPTTooltip N,N-Diisopropyltryptamine
- DPTTooltip N,N-Dipropyltryptamine
- Ibogaine
- Imipramine
- KCR-12-83.1
- Nemonapride
- Noribogaine
- RHL-033
- RS-67,333
- RTI-55
- Saffron
- Safinamide
- Selegiline
- Spipethiane
- Trifluoperazine
- W-18
- YKP10A
- Agonists: 3-PPP
- Arketamine
- BD-1047
- BD1063
- Ditolylguanidine (DTG)
- DKR-1005
- DKR-1051
- Haloperidol
- Ifenprodil
- Ketamine
- MDMA (midomafetamine)
- Methamphetamine
- OPC-14523
- Opipramol
- PB-28
- Phencyclidine
- Siramesine (Lu 28-179)
- UKH-1114
- Unknown/unsorted: 3-Methoxydextrallorphan
- 3-MeO-PCE
- 4-MeO-PCP
- 5-MeO-DALT
- 5-MeO-DiPT
- Clemastine
- DiPTTooltip N,N-Diisopropyltryptamine
- DPTTooltip N,N-Dipropyltryptamine
- Ibogaine
- Nemonapride
- Nepinalone
- Noribogaine
- Pentazocine
- RS-67,333
- Safinamide
- TMATooltip 3,4,5-Trimethoxyamphetamine
- UMB-23
- UMB-82
- W-18
- Antagonists: AHD1
- AZ66
- Lamotrigine
- Naloxone
- SM-21
- UMB-100
- UMB-101
- UMB-103
- UMB-116
- YZ-011
- YZ-069
- YZ-185
- Allosteric modulators: SKF-83959
- Unknown/unsorted: 18-Methoxycoronaridine
- BMY-13980
- Butaclamol
- Caramiphen
- Carvotroline
- Chlorphenamine (chlorpheniramine)
- Chlorpromazine
- Cinnarizine
- Cinuperone
- Clocapramine
- Dezocine
- EMD-59983
- Hypericin (St. John's wort)
- Fluphenazine
- Gevotroline (WY-47384)
- Mepyramine (pyrilamine)
- Molindone
- Perphenazine
- Pimozide
- Proadifen
- Promethazine
- Propranolol
- Quinidine
- Remoxipride
- SL 82.0715
- SR-31747A
- Tiospirone (BMY-13859)
- Venlafaxine
See also: Receptor/signaling modulators
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