Divaplon
Chemical compound
- none
- (6-ethyl-7-methoxy-5-methylimidazo[1,2-a]pyrimidin-2-yl)-phenylmethanone
- 90808-12-1 Y
- 65822
- 59234
- 4AOV43246G
- ChEMBL281164
- DTXSID40238269
- Interactive image
- CCC1=C(N2C=C(N=C2N=C1OC)C(=O)C3=CC=CC=C3)C
InChI
- InChI=1S/C17H17N3O2/c1-4-13-11(2)20-10-14(18-17(20)19-16(13)22-3)15(21)12-8-6-5-7-9-12/h5-10H,4H2,1-3H3
- Key:NRJVHCSYLGLURI-UHFFFAOYSA-N
Divaplon (RU-32698) is a nonbenzodiazepine, anxiolytic and anticonvulsant drug from the imidazopyrimidine family of drugs. It acts as a partial agonist at the "benzodiazepine site" of the GABAA receptor in the brain.[1][2][3]
References
- ^ Feely M, Boyland P, Picardo A, Cox A, Gent JP (May 1989). "Lack of anticonvulsant tolerance with RU 32698 and Ro 17-1812". European Journal of Pharmacology. 164 (2): 377–80. doi:10.1016/0014-2999(89)90482-2. PMID 2759183.
- ^ Sanger DJ, Joly D, Perrault G (September 1995). "Benzodiazepine (omega) receptor partial agonists and the acquisition of conditioned fear in mice". Psychopharmacology. 121 (1): 104–8. doi:10.1007/BF02245596. PMID 8539334. S2CID 32627339.
- ^ Pellón R, Ruíz A, Lamas E, Rodríguez C (February 2007). "Pharmacological analysis of the effects of benzodiazepines on punished schedule-induced polydipsia in rats". Behavioural Pharmacology. 18 (1): 81–7. doi:10.1097/FBP.0b013e3280143212. PMID 17218801. S2CID 40188048.
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- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III