Protein-coding gene in the species Homo sapiens
DOK6 |
---|
|
Identifiers |
---|
Aliases | DOK6, DOK5L, HsT3226, docking protein 6 |
---|
External IDs | OMIM: 611402; MGI: 3639495; HomoloGene: 45143; GeneCards: DOK6; OMA:DOK6 - orthologs |
---|
Gene location (Human) |
---|
| Chr. | Chromosome 18 (human)[1] |
---|
| Band | 18q22.2 | Start | 69,400,888 bp[1] |
---|
End | 69,849,087 bp[1] |
---|
|
Gene location (Mouse) |
---|
| Chr. | Chromosome 18 (mouse)[2] |
---|
| Band | 18|18 E4 | Start | 89,310,548 bp[2] |
---|
End | 89,787,652 bp[2] |
---|
|
RNA expression pattern |
---|
Bgee | Human | Mouse (ortholog) |
---|
Top expressed in | - Brodmann area 46
- pons
- endothelial cell
- middle temporal gyrus
- ganglionic eminence
- entorhinal cortex
- Brodmann area 23
- spinal ganglia
- ventral tegmental area
- superior frontal gyrus
|
| Top expressed in | - hippocampus proper
- superior frontal gyrus
- olfactory bulb
- hypothalamus
- cerebellar cortex
- ganglionic eminence
- mesencephalon
- neural tube
- spinal ganglia
- trigeminal ganglion
|
| More reference expression data |
|
---|
BioGPS | |
---|
|
Gene ontology |
---|
Molecular function | | Cellular component | | Biological process | | Sources:Amigo / QuickGO |
|
Orthologs |
---|
Species | Human | Mouse |
---|
Entrez | | |
---|
Ensembl | | |
---|
UniProt | | |
---|
RefSeq (mRNA) | | |
---|
RefSeq (protein) | | |
---|
Location (UCSC) | Chr 18: 69.4 – 69.85 Mb | Chr 18: 89.31 – 89.79 Mb |
---|
PubMed search | [3] | [4] |
---|
|
Wikidata |
View/Edit Human | View/Edit Mouse |
|
Docking protein 6 is a protein that in humans is encoded by the DOK6 gene. [5]
Function
DOK6 is a member of the DOK (see DOK1; MIM 602919) family of intracellular adaptors that play a role in the RET (MIM 164761) signaling cascade (Crowder et al., 2004 [PubMed 15286081]).
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000206052 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000073514 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: Docking protein 6". Retrieved 2017-02-01.
Further reading
- Crowder RJ, Enomoto H, Yang M, Johnson EM, Milbrandt J (2004). "Dok-6, a Novel p62 Dok family member, promotes Ret-mediated neurite outgrowth". J. Biol. Chem. 279 (40): 42072–81. doi:10.1074/jbc.M403726200. PMID 15286081.
- Kurotsuchi A, Murakumo Y, Jijiwa M, Kurokawa K, Itoh Y, Kodama Y, Kato T, Enomoto A, Asai N, Terasaki H, Takahashi M (2010). "Analysis of DOK-6 function in downstream signaling of RET in human neuroblastoma cells". Cancer Sci. 101 (5): 1147–55. doi:10.1111/j.1349-7006.2010.01520.x. PMID 20210798. S2CID 11769638.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.