Docking protein 6

Protein-coding gene in the species Homo sapiens
DOK6
Identifiers
AliasesDOK6, DOK5L, HsT3226, docking protein 6
External IDsOMIM: 611402; MGI: 3639495; HomoloGene: 45143; GeneCards: DOK6; OMA:DOK6 - orthologs
Gene location (Human)
Chromosome 18 (human)
Chr.Chromosome 18 (human)[1]
Chromosome 18 (human)
Genomic location for DOK6
Genomic location for DOK6
Band18q22.2Start69,400,888 bp[1]
End69,849,087 bp[1]
Gene location (Mouse)
Chromosome 18 (mouse)
Chr.Chromosome 18 (mouse)[2]
Chromosome 18 (mouse)
Genomic location for DOK6
Genomic location for DOK6
Band18|18 E4Start89,310,548 bp[2]
End89,787,652 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • Brodmann area 46

  • pons

  • endothelial cell

  • middle temporal gyrus

  • ganglionic eminence

  • entorhinal cortex

  • Brodmann area 23

  • spinal ganglia

  • ventral tegmental area

  • superior frontal gyrus
Top expressed in
  • hippocampus proper

  • superior frontal gyrus

  • olfactory bulb

  • hypothalamus

  • cerebellar cortex

  • ganglionic eminence

  • mesencephalon

  • neural tube

  • spinal ganglia

  • trigeminal ganglion
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • protein binding
Cellular component
  • cytosol
Biological process
  • axon guidance
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

220164

623279

Ensembl

ENSG00000206052

ENSMUSG00000073514

UniProt

Q6PKX4

Q2MHE5

RefSeq (mRNA)

NM_152721

NM_001039173

RefSeq (protein)

NP_689934

NP_001034262

Location (UCSC)Chr 18: 69.4 – 69.85 MbChr 18: 89.31 – 89.79 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Docking protein 6 is a protein that in humans is encoded by the DOK6 gene. [5]

Function

DOK6 is a member of the DOK (see DOK1; MIM 602919) family of intracellular adaptors that play a role in the RET (MIM 164761) signaling cascade (Crowder et al., 2004 [PubMed 15286081]).

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000206052 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000073514 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Docking protein 6". Retrieved 2017-02-01.

Further reading

  • Crowder RJ, Enomoto H, Yang M, Johnson EM, Milbrandt J (2004). "Dok-6, a Novel p62 Dok family member, promotes Ret-mediated neurite outgrowth". J. Biol. Chem. 279 (40): 42072–81. doi:10.1074/jbc.M403726200. PMID 15286081.
  • Kurotsuchi A, Murakumo Y, Jijiwa M, Kurokawa K, Itoh Y, Kodama Y, Kato T, Enomoto A, Asai N, Terasaki H, Takahashi M (2010). "Analysis of DOK-6 function in downstream signaling of RET in human neuroblastoma cells". Cancer Sci. 101 (5): 1147–55. doi:10.1111/j.1349-7006.2010.01520.x. PMID 20210798. S2CID 11769638.


  • v
  • t
  • e

This article incorporates text from the United States National Library of Medicine, which is in the public domain.