Domoprednate
Chemical compound
Clinical data | |
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Trade names | Stermonid |
Other names | Ro 12-7024; 11β-Hydroxy-D-homopregna-1,4-diene-3,20-dione 17α-butyrate |
Routes of administration | Topical |
Drug class | Corticosteroid; Glucocorticoid |
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ECHA InfoCard | 100.060.441 |
Chemical and physical data | |
Formula | C26H36O5 |
Molar mass | 428.569 g·mol−1 |
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Domoprednate (brand name Stermonid; developmental code name Ro 12-7024) is a synthetic glucocorticoid corticosteroid which was developed in the late 1970s and 1980s.[1][2][3][4][5]
References
- ^ J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 465–. ISBN 978-1-4757-2085-3.
- ^ Schmidt H, Hjorth N, Holm P (1984). "A randomized trial on the D-homosteroid domoprednate (Ro 12-7024) in the treatment of dermatoses". Dermatologica. 168 (3): 127–30. doi:10.1159/000249683. PMID 6370748.
- ^ Serup J, Holm P (1985). "Domoprednate (Stermonid), a topical D-homocorticosteroid, skin atrophy and telangiectasia. A double-blind, randomized comparison with hydrocortisone butyrate, betamethasone valerate, clobetasole propionate and placebo". Dermatologica. 170 (4): 189–94. doi:10.1159/000249529. PMID 3888708.
- ^ Christiansen JV, Foged E, Holm P, Jørgensen AS, Reymann F (1985). "The treatment of psoriasis with 0.1% domoprednate (a D-homocorticosteroid) and 0.1% betamethasone valerate ointment. A double-blind, randomized trial". Dermatologica. 170 (4): 195–8. doi:10.1159/000249530. PMID 3888709.
- ^ Schmidt H, Hjorth N, Holm P (1987). "Domoprednate, a new nonhalogenated topical steroid: comparison to hydrocortisone butyrate". Dermatologica. 175 (3): 145–7. doi:10.1159/000248813. PMID 3653463.
- v
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- Antagonists: Aglepristone
- Ketoconazole
- Mifepristone
- Ulipristal acetate
- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
- See also
- Glucocorticoid receptor modulators
- Mineralocorticoids and antimineralocorticoids
- List of corticosteroids
This article about a steroid is a stub. You can help Wikipedia by expanding it. |
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