Dornase alfa

Pharmaceutical drug
  • US DailyMed: Dornase alfa
Pregnancy
category
Routes of
administrationInhalationATC code
  • R05CB13 (WHO)
Legal statusLegal status
  • AU: S4 (Prescription only)[1]
  • CA: ℞-only / Schedule D[2]
  • US: ℞-only[3]
  • In general: ℞ (Prescription only)
IdentifiersCAS Number
  • 143831-71-4 ☒N
DrugBank
  • DB00003 checkY
ChemSpider
  • none
UNII
  • 953A26OA1Y
KEGG
  • D03896
CompTox Dashboard (EPA)
  • DTXSID801010888 Edit this at Wikidata
ECHA InfoCard100.029.685 Edit this at WikidataChemical and physical dataFormulaC1321H1999N339O396S9Molar mass29254.04 g·mol−1 ☒NcheckY (what is this?)  (verify)

Dornase alfa, sold under the brand name Pulmozyme, is used for the treatment of cystic fibrosis.[3] It is a recombinant human deoxyribonuclease I (rhDNase), an enzyme which selectively cleaves DNA.[3] Dornase alfa hydrolyzes the DNA present in sputum/mucus and reduces viscosity in the lungs, promoting improved clearance of secretions.[3] It is produced in Chinese hamster ovary cells.[3]

Medical uses

Dornase alfa is indicated for the management of people with cystic fibrosis to improve pulmonary function.[3]

Society and culture

Legal status

Dornase alfa is an orphan drug.[4]

Research

Dornase alfa has been shown to improve lung function in non-cystic fibrosis pre-term infants atelectasis.[5][6]

References

  1. ^ a b Product guildlink.com.au
  2. ^ "Pulmozyme Product information". Health Canada. 25 April 2012. Retrieved 9 January 2023.
  3. ^ a b c d e f "Pulmozyme- dornase alfa solution". DailyMed. 21 October 2020. Retrieved 9 January 2023.
  4. ^ Collier, Joe (1 September 1995). "Dornase-alfa and orphan drugs". The Lancet. 346 (8975): 633. doi:10.1016/S0140-6736(95)91460-9. PMID 7651014. S2CID 5456247.
  5. ^ Erdeve O, Uras N, Atasay B, Arsan S (2007). "Efficacy and safety of nebulized recombinant human DNase as rescue treatment for persistent atelectasis in newborns: case-series". Croat Med J. 48 (2): 234–9. PMC 2080511. PMID 17436388.
  6. ^ Hendriks T, de Hoog M, Lequin MH, Devos AS, Merkus PJ (2005). "DNase and atelectasis in non-cystic fibrosis pediatric patients". Crit Care. 9 (4): R351-6. doi:10.1186/cc3544. PMC 1269442. PMID 16137347.
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