ELF2

Protein-coding gene in the species Homo sapiens
ELF2
Identifiers
AliasesELF2, EU32, NERF, NERF-1A, NERF-1B, NERF-1a,b, NERF-2, E74 like ETS transcription factor 2
External IDsMGI: 1916507 HomoloGene: 5006 GeneCards: ELF2
Gene location (Human)
Chromosome 4 (human)
Chr.Chromosome 4 (human)[1]
Chromosome 4 (human)
Genomic location for ELF2
Genomic location for ELF2
Band4q31.1Start139,028,112 bp[1]
End139,177,218 bp[1]
Gene location (Mouse)
Chromosome 3 (mouse)
Chr.Chromosome 3 (mouse)[2]
Chromosome 3 (mouse)
Genomic location for ELF2
Genomic location for ELF2
Band3|3 CStart51,160,141 bp[2]
End51,248,084 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • Achilles tendon

  • ganglionic eminence

  • right lung

  • ascending aorta

  • blood

  • corpus callosum

  • minor salivary glands

  • gastric mucosa

  • sural nerve

  • thymus
Top expressed in
  • spermatocyte

  • spermatid

  • seminiferous tubule

  • ganglionic eminence

  • dermis

  • thymus

  • placenta

  • ankle

  • adrenal gland

  • superior cervical ganglion
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • DNA-binding transcription factor activity
  • sequence-specific DNA binding
  • DNA binding
  • protein binding
  • DNA-binding transcription factor activity, RNA polymerase II-specific
Cellular component
  • nucleus
  • cytosol
  • nuclear body
  • nucleoplasm
Biological process
  • regulation of transcription by RNA polymerase II
  • positive regulation of transcription, DNA-templated
  • cell differentiation
  • negative regulation of transcription, DNA-templated
  • regulation of transcription, DNA-templated
  • transcription, DNA-templated
  • regulation of B cell receptor signaling pathway
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

1998

69257

Ensembl

ENSG00000109381

ENSMUSG00000037174

UniProt

Q15723

Q9JHC9

RefSeq (mRNA)
NM_001276457
NM_001276458
NM_001276459
NM_006874
NM_201999

NM_001331036

NM_001291059
NM_001291062
NM_001291063
NM_023502
NM_001356358

RefSeq (protein)
NP_001263386
NP_001263387
NP_001263388
NP_001317965
NP_006865

NP_973728
NP_001358253
NP_001358265
NP_001358266
NP_001358267
NP_001358268

NP_001277988
NP_001277991
NP_001277992
NP_075991
NP_001343287

Location (UCSC)Chr 4: 139.03 – 139.18 MbChr 3: 51.16 – 51.25 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

E74-like factor 2 (ELF2), formerly known as new Ets-related factor (NERF), is an ETS family transcription factor.[5] In humans this protein is encoded by the ELF2 gene.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000109381 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000037174 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Oettgen P, Akbarali Y, Boltax J, Best J, Kunsch C, Libermann TA (September 1996). "Characterization of NERF, a novel transcription factor related to the Ets factor ELF-1". Mol. Cell. Biol. 16 (9): 5091–106. doi:10.1128/MCB.16.9.5091. PMC 231510. PMID 8756667.
  6. ^ "Entrez Gene: ELF2 E74-like factor 2 (ets domain transcription factor)".

Further reading

  • Wilkinson DA, Neale GA, Mao S, et al. (1997). "Elf-2, a rhombotin-2 binding ets transcription factor: discovery and potential role in T cell leukemia". Leukemia. 11 (1): 86–96. doi:10.1038/sj.leu.2400516. PMID 9001422.
  • Mao S, Frank RC, Zhang J, et al. (1999). "Functional and physical interactions between AML1 proteins and an ETS protein, MEF: implications for the pathogenesis of t(8;21)-positive leukemias". Mol. Cell. Biol. 19 (5): 3635–44. doi:10.1128/mcb.19.5.3635. PMC 84165. PMID 10207087.
  • Christensen RA, Fujikawa K, Madore R, et al. (2002). "NERF2, a member of the Ets family of transcription factors, is increased in response to hypoxia and angiopoietin-1: a potential mechanism for Tie2 regulation during hypoxia". J. Cell. Biochem. 85 (3): 505–15. doi:10.1002/jcb.10148. PMID 11967990. S2CID 36902890.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Cho JY, Akbarali Y, Zerbini LF, et al. (2004). "Isoforms of the Ets transcription factor NERF/ELF-2 physically interact with AML1 and mediate opposing effects on AML1-mediated transcription of the B cell-specific blk gene". J. Biol. Chem. 279 (19): 19512–22. doi:10.1074/jbc.M309074200. PMID 14970218.
  • Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Zhang B, Tomita Y, Qiu Y, et al. (2007). "E74-like factor 2 regulates valosin-containing protein expression". Biochem. Biophys. Res. Commun. 356 (3): 536–41. doi:10.1016/j.bbrc.2007.02.160. PMID 17368566.
  • v
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  • e
(1) Basic domains
(1.1) Basic leucine zipper (bZIP)
(1.2) Basic helix-loop-helix (bHLH)
Group A
Group B
Group C
bHLH-PAS
Group D
Group E
Group F
bHLH-COE
(1.3) bHLH-ZIP
(1.4) NF-1
(1.5) RF-X
(1.6) Basic helix-span-helix (bHSH)
(2) Zinc finger DNA-binding domains
(2.1) Nuclear receptor (Cys4)
subfamily 1
subfamily 2
subfamily 3
subfamily 4
subfamily 5
subfamily 6
subfamily 0
(2.2) Other Cys4
(2.3) Cys2His2
(2.4) Cys6
(2.5) Alternating composition
(2.6) WRKY
(3) Helix-turn-helix domains
(3.1) Homeodomain
Antennapedia
ANTP class
protoHOX
Hox-like
metaHOX
NK-like
other
(3.2) Paired box
(3.3) Fork head / winged helix
(3.4) Heat shock factors
(3.5) Tryptophan clusters
(3.6) TEA domain
  • transcriptional enhancer factor
(4) β-Scaffold factors with minor groove contacts
(4.1) Rel homology region
(4.2) STAT
(4.3) p53-like
(4.4) MADS box
(4.6) TATA-binding proteins
(4.7) High-mobility group
(4.9) Grainyhead
(4.10) Cold-shock domain
(4.11) Runt
(0) Other transcription factors
(0.2) HMGI(Y)
(0.3) Pocket domain
(0.5) AP-2/EREBP-related factors
(0.6) Miscellaneous
see also transcription factor/coregulator deficiencies


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