ELF4

Protein-coding gene in humans
ELF4
Identifiers
AliasesELF4, ELFR, MEF, E74 like ETS transcription factor 4, AIFBL2
External IDsOMIM: 300775 MGI: 1928377 HomoloGene: 31036 GeneCards: ELF4
Gene location (Human)
X chromosome (human)
Chr.X chromosome (human)[1]
X chromosome (human)
Genomic location for ELF4
Genomic location for ELF4
BandXq26.1Start130,063,955 bp[1]
End130,110,716 bp[1]
Gene location (Mouse)
X chromosome (mouse)
Chr.X chromosome (mouse)[2]
X chromosome (mouse)
Genomic location for ELF4
Genomic location for ELF4
BandX|X A5Start47,499,923 bp[2]
End47,552,009 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • blood

  • monocyte

  • germinal epithelium

  • jejunal mucosa

  • parietal pleura

  • placenta

  • bone marrow

  • bone marrow cells

  • tibia

  • squamous epithelium
Top expressed in
  • ascending aorta

  • aortic valve

  • urethra

  • male urethra

  • thymus

  • lip

  • epithelium of urethra

  • yolk sac

  • membranous bone

  • mucosa of small intestine
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • RNA polymerase II cis-regulatory region sequence-specific DNA binding
  • DNA-binding transcription factor activity
  • DNA binding
  • sequence-specific DNA binding
  • DNA-binding transcription activator activity, RNA polymerase II-specific
  • protein binding
  • DNA-binding transcription factor activity, RNA polymerase II-specific
Cellular component
  • PML body
  • nucleus
  • nucleoplasm
  • nuclear body
Biological process
  • natural killer cell proliferation
  • positive regulation of transcription, DNA-templated
  • NK T cell proliferation
  • cell differentiation
  • innate immune response
  • regulation of transcription, DNA-templated
  • transcription, DNA-templated
  • positive regulation of transcription by RNA polymerase II
  • transcription by RNA polymerase II
  • regulation of transcription by RNA polymerase II
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

2000

56501

Ensembl

ENSG00000102034

ENSMUSG00000031103

UniProt

Q99607

Q9Z2U4

RefSeq (mRNA)

NM_001127197
NM_001421

NM_019680
NM_001381876

RefSeq (protein)

NP_001120669
NP_001412

NP_062654
NP_001368805

Location (UCSC)Chr X: 130.06 – 130.11 MbChr X: 47.5 – 47.55 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

ETS-related transcription factor Elf-4 is a protein that in humans is encoded by the ELF4 gene.[5][6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000102034 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031103 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Miyazaki Y, Sun X, Uchida H, Zhang J, Nimer S (October 1996). "MEF, a novel transcription factor with an Elf-1 like DNA binding domain but distinct transcriptional activating properties". Oncogene. 13 (8): 1721–9. PMID 8895518.
  6. ^ "Entrez Gene: ELF4 E74-like factor 4 (ets domain transcription factor)".

Further reading

  • Liu Y, Hedvat CV, Mao S, Zhu XH, Yao J, Nguyen H, Koff A, Nimer SD (April 2006). "The ETS protein MEF is regulated by phosphorylation-dependent proteolysis via the protein-ubiquitin ligase SCFSkp2". Molecular and Cellular Biology. 26 (8): 3114–23. doi:10.1128/MCB.26.8.3114-3123.2006. PMC 1446966. PMID 16581786.
  • Moore SD, Offor O, Ferry JA, Amrein PC, Morton CC, Dal Cin P (August 2006). "ELF4 is fused to ERG in a case of acute myeloid leukemia with a t(X;21)(q25-26;q22)". Leukemia Research. 30 (8): 1037–42. doi:10.1016/j.leukres.2005.10.014. PMID 16303180.
  • Lu Z, Kim KA, Suico MA, Shuto T, Li JD, Kai H (March 2004). "MEF up-regulates human beta-defensin 2 expression in epithelial cells". FEBS Letters. 561 (1–3): 117–21. doi:10.1016/S0014-5793(04)00138-3. PMID 15013761. S2CID 86612269.
  • Suico MA, Yoshida H, Seki Y, Uchikawa T, Lu Z, Shuto T, Matsuzaki K, Nakao M, Li JD, Kai H (April 2004). "Myeloid Elf-1-like factor, an ETS transcription factor, up-regulates lysozyme transcription in epithelial cells through interaction with promyelocytic leukemia protein". The Journal of Biological Chemistry. 279 (18): 19091–8. doi:10.1074/jbc.M312439200. PMID 14976184.
  • Cho JY, Akbarali Y, Zerbini LF, Gu X, Boltax J, Wang Y, Oettgen P, Zhang DE, Libermann TA (May 2004). "Isoforms of the Ets transcription factor NERF/ELF-2 physically interact with AML1 and mediate opposing effects on AML1-mediated transcription of the B cell-specific blk gene". The Journal of Biological Chemistry. 279 (19): 19512–22. doi:10.1074/jbc.M309074200. PMID 14970218.
  • Hedvat CV, Yao J, Sokolic RA, Nimer SD (February 2004). "Myeloid ELF1-like factor is a potent activator of interleukin-8 expression in hematopoietic cells". The Journal of Biological Chemistry. 279 (8): 6395–400. doi:10.1074/jbc.M307524200. PMID 14625302.
  • Suico MA, Koyanagi T, Ise S, Lu Z, Hisatsune A, Seki Y, Shuto T, Isohama Y, Miyata T, Kai H (August 2002). "Functional dissection of the ETS transcription factor MEF". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1577 (1): 113–20. doi:10.1016/s0167-4781(02)00370-6. PMID 12151102.
  • Mao S, Frank RC, Zhang J, Miyazaki Y, Nimer SD (May 1999). "Functional and physical interactions between AML1 proteins and an ETS protein, MEF: implications for the pathogenesis of t(8;21)-positive leukemias". Molecular and Cellular Biology. 19 (5): 3635–44. doi:10.1128/mcb.19.5.3635. PMC 84165. PMID 10207087.
  • Aryee DN, Petermann R, Kos K, Henn T, Haas OA, Kovar H (March 1998). "Cloning of a novel human ELF-1-related ETS transcription factor, ELFR, its characterization and chromosomal assignment relative to ELF-1". Gene. 210 (1): 71–8. doi:10.1016/S0378-1119(98)00022-5. PMID 9524226.

External links

  • v
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(1) Basic domains
(1.1) Basic leucine zipper (bZIP)
(1.2) Basic helix-loop-helix (bHLH)
Group A
Group B
Group C
bHLH-PAS
Group D
Group E
Group F
bHLH-COE
(1.3) bHLH-ZIP
(1.4) NF-1
(1.5) RF-X
(1.6) Basic helix-span-helix (bHSH)
(2) Zinc finger DNA-binding domains
(2.1) Nuclear receptor (Cys4)
subfamily 1
subfamily 2
subfamily 3
subfamily 4
subfamily 5
subfamily 6
subfamily 0
(2.2) Other Cys4
(2.3) Cys2His2
(2.4) Cys6
(2.5) Alternating composition
(2.6) WRKY
(3) Helix-turn-helix domains
(3.1) Homeodomain
Antennapedia
ANTP class
protoHOX
Hox-like
metaHOX
NK-like
other
(3.2) Paired box
(3.3) Fork head / winged helix
(3.4) Heat shock factors
(3.5) Tryptophan clusters
(3.6) TEA domain
  • transcriptional enhancer factor
(4) β-Scaffold factors with minor groove contacts
(4.1) Rel homology region
(4.2) STAT
(4.3) p53-like
(4.4) MADS box
(4.6) TATA-binding proteins
(4.7) High-mobility group
(4.9) Grainyhead
(4.10) Cold-shock domain
(4.11) Runt
(0) Other transcription factors
(0.2) HMGI(Y)
(0.3) Pocket domain
(0.5) AP-2/EREBP-related factors
(0.6) Miscellaneous
see also transcription factor/coregulator deficiencies


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