ERGIC3

Protein-coding gene in the species Homo sapiens
ERGIC3
Identifiers
AliasesERGIC3, C20orf47, CGI-54, Erv46, NY-BR-84, PRO0989, SDBCAG84, dJ477O4.2, ERGIC and golgi 3, C2orf47
External IDsOMIM: 616971; MGI: 1913616; HomoloGene: 5289; GeneCards: ERGIC3; OMA:ERGIC3 - orthologs
Gene location (Human)
Chromosome 20 (human)
Chr.Chromosome 20 (human)[1]
Chromosome 20 (human)
Genomic location for ERGIC3
Genomic location for ERGIC3
Band20q11.22Start35,542,038 bp[1]
End35,557,634 bp[1]
Gene location (Mouse)
Chromosome 2 (mouse)
Chr.Chromosome 2 (mouse)[2]
Chromosome 2 (mouse)
Genomic location for ERGIC3
Genomic location for ERGIC3
Band2 H1|2 77.32 cMStart155,849,965 bp[2]
End155,860,199 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • right uterine tube

  • right testis

  • left testis

  • stromal cell of endometrium

  • olfactory zone of nasal mucosa

  • right lobe of thyroid gland

  • left lobe of thyroid gland

  • canal of the cervix

  • mucosa of transverse colon

  • left ovary
Top expressed in
  • molar

  • neural layer of retina

  • yolk sac

  • choroid plexus of fourth ventricle

  • right kidney

  • dentate gyrus of hippocampal formation granule cell

  • external carotid artery

  • vestibular sensory epithelium

  • epithelium of lens

  • tail of embryo
More reference expression data
BioGPS
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

51614

66366

Ensembl

ENSG00000125991

ENSMUSG00000005881

UniProt

Q9Y282

Q9CQE7

RefSeq (mRNA)

NM_015966
NM_198398

NM_025516
NM_001356413
NM_001356414

RefSeq (protein)

NP_057050
NP_938408

NP_079792
NP_001343342
NP_001343343

Location (UCSC)Chr 20: 35.54 – 35.56 MbChr 2: 155.85 – 155.86 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Endoplasmic reticulum-Golgi intermediate compartment protein 3 is a protein that in humans is encoded by the ERGIC3 gene.[5][6] It has been reported to be regulated by micro RNAs and may be important in a cancer.[7][8]



References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000125991 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000005881 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Lai CH, Chou CY, Ch'ang LY, Liu CS, Lin W (Aug 2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Res. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC 310876. PMID 10810093.
  6. ^ "Entrez Gene: ERGIC3 ERGIC and golgi 3".
  7. ^ Zhang, Ling-yun; Liu, Min; Li, Xin; Tang, Hua (2013). "miR-490-3p Modulates Cell Growth and Epithelial to Mesenchymal Transition of Hepatocellular Carcinoma Cells by Targeting Endoplasmic Reticulum-Golgi Intermediate Compartment Protein 3 (ERGIC3)". Journal of Biological Chemistry. 288 (6): 4035–4047. doi:10.1074/jbc.M112.410506. ISSN 0021-9258. PMC 3567655. PMID 23212913.
  8. ^ Lin, Qing-Hai; Zhang, Kui-Dong; Duan, He-Xian; Liu, Min-Xia; Wei, Wan-Li; Cao, Yi (2015). "ERGIC3, which is regulated by miR-203a, is a potential biomarker for non-small cell lung cancer". Cancer Science. 106 (10): 1463–1473. doi:10.1111/cas.12741. ISSN 1347-9032. PMC 4638005. PMID 26177443.

Further reading

  • Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode:2001Natur.414..865D. doi:10.1038/414865a. PMID 11780052.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Scanlan MJ, Gout I, Gordon CM, et al. (2003). "Humoral immunity to human breast cancer: antigen definition and quantitative analysis of mRNA expression". Cancer Immun. 1: 4. PMID 12747765.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Breuza L, Halbeisen R, Jenö P, et al. (2004). "Proteomics of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membranes from brefeldin A-treated HepG2 cells identifies ERGIC-32, a new cycling protein that interacts with human Erv46". J. Biol. Chem. 279 (45): 47242–53. doi:10.1074/jbc.M406644200. PMID 15308636.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
  • Nishikawa M, Kira Y, Yabunaka Y, Inoue M (2007). "Identification and characterization of endoplasmic reticulum-associated protein, ERp43". Gene. 386 (1–2): 42–51. doi:10.1016/j.gene.2006.06.030. PMID 17020792.


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