ERMAP

Protein-coding gene in the species Homo sapiens
ERMAP
Identifiers
AliasesERMAP, BTN5, PRO2801, RD, SC, erythroblast membrane associated protein (Scianna blood group)
External IDsOMIM: 609017 MGI: 1349816 HomoloGene: 22782 GeneCards: ERMAP
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for ERMAP
Genomic location for ERMAP
Band1p34.2Start42,817,122 bp[1]
End42,844,991 bp[1]
Gene location (Mouse)
Chromosome 4 (mouse)
Chr.Chromosome 4 (mouse)[2]
Chromosome 4 (mouse)
Genomic location for ERMAP
Genomic location for ERMAP
Band4 D2.1|4 55.34 cMStart119,032,654 bp[2]
End119,047,208 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • monocyte

  • right lobe of liver

  • stromal cell of endometrium

  • left adrenal gland

  • trabecular bone

  • body of pancreas

  • rectum

  • bone marrow

  • anterior pituitary

  • left lobe of thyroid gland
Top expressed in
  • retinal pigment epithelium

  • body of femur

  • spleen

  • bone marrow

  • yolk sac

  • lens

  • blood

  • endocardial cushion

  • abdominal wall

  • placenta
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • signaling receptor binding
Cellular component
  • cytoplasm
  • membrane
  • integral component of membrane
  • plasma membrane
  • external side of plasma membrane
Biological process
  • regulation of immune response
  • T cell receptor signaling pathway
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

114625

27028

Ensembl

ENSG00000164010

ENSMUSG00000028644

UniProt

Q96PL5

Q9JLN5

RefSeq (mRNA)

NM_001017922
NM_018538

NM_013848
NM_001369066

RefSeq (protein)

NP_001017922
NP_061008

NP_038876
NP_001355995

Location (UCSC)Chr 1: 42.82 – 42.84 MbChr 4: 119.03 – 119.05 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Erythroid membrane-associated protein is a protein that in humans is responsible for the Scianna blood group system, and is encoded by the ERMAP gene.[5][6]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000164010 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028644 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Xu H, Foltz L, Sha Y, Madlansacay MR, Cain C, Lindemann G, Vargas J, Nagy D, Harriman B, Mahoney W, Schueler PA (Sep 2001). "Cloning and characterization of human erythroid membrane-associated protein, human ERMAP". Genomics. 76 (1–3): 2–4. doi:10.1006/geno.2001.6600. PMID 11549310.
  6. ^ "Entrez Gene: ERMAP erythroblast membrane-associated protein (Scianna blood group)".

Further reading

  • Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
  • Flegel WA, Chen Q, Reid ME, et al. (2006). "SCER and SCAN: two novel high-prevalence antigens in the Scianna blood group system". Transfusion. 45 (12): 1940–4. doi:10.1111/j.1537-2995.2005.00646.x. PMID 16371048. S2CID 6030307.
  • Hue-Roye K, Chaudhuri A, Velliquette RW, et al. (2005). "STAR: a novel high-prevalence antigen in the Scianna blood group system". Transfusion. 45 (2): 245–7. doi:10.1111/j.1537-2995.2004.04226.x. PMID 15660834. S2CID 782824.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Krause M, Leslie JD, Stewart M, et al. (2004). "Lamellipodin, an Ena/VASP ligand, is implicated in the regulation of lamellipodial dynamics". Dev. Cell. 7 (4): 571–83. doi:10.1016/j.devcel.2004.07.024. PMID 15469845.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Wagner FF, Poole J, Flegel WA (2003). "Scianna antigens including Rd are expressed by ERMAP". Blood. 101 (2): 752–7. doi:10.1182/blood-2002-07-2064. PMID 12393480.
  • Su YY, Gordon CT, Ye TZ, et al. (2003). "Human ERMAP: an erythroid adhesion/receptor transmembrane protein". Blood Cells Mol. Dis. 27 (5): 938–49. doi:10.1006/bcmd.2001.0465. PMID 11783959.
  • Lewis M, Kaita H, Philipps S, et al. (1982). "The position of the Radin blood group locus in relation to other chromosome l loci". Ann. Hum. Genet. 44 (Pt 2): 179–84. doi:10.1111/j.1469-1809.1980.tb00956.x. PMID 6459052. S2CID 30044562.
  • Lewis M, Kaita H (1980). "Genetic linkage between the Radin and Rh blood group loci". Vox Sang. 37 (5): 286–9. doi:10.1111/j.1423-0410.1979.tb02306.x. PMID 118583. S2CID 31800860.

External links

  • Scianna blood group system in the BGMUT blood group antigen gene mutation database


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