ETV1

Protein-coding gene in the species Homo sapiens
ETV1
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

4AVP, 4BNC

Identifiers
AliasesETV1, ER81, ETS variant 1, ETS variant transcription factor 1
External IDsOMIM: 600541 MGI: 99254 HomoloGene: 3636 GeneCards: ETV1
Gene location (Human)
Chromosome 7 (human)
Chr.Chromosome 7 (human)[1]
Chromosome 7 (human)
Genomic location for ETV1
Genomic location for ETV1
Band7p21.2Start13,891,229 bp[1]
End13,991,425 bp[1]
Gene location (Mouse)
Chromosome 12 (mouse)
Chr.Chromosome 12 (mouse)[2]
Chromosome 12 (mouse)
Genomic location for ETV1
Genomic location for ETV1
Band12 A3|12 17.99 cMStart38,829,379 bp[2]
End38,920,483 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • cerebellar vermis

  • parotid gland

  • cerebellar hemisphere

  • visceral pleura

  • lower lobe of lung

  • right ventricle

  • right lung

  • islet of Langerhans

  • gallbladder

  • Region I of hippocampus proper
Top expressed in
  • parotid gland

  • cerebellar vermis

  • habenula

  • subiculum

  • submandibular gland

  • lacrimal gland

  • olfactory bulb

  • globus pallidus

  • otolith organ

  • utricle
More reference expression data
BioGPS




More reference expression data
Gene ontology
Molecular function
  • DNA-binding transcription factor activity
  • RNA polymerase II cis-regulatory region sequence-specific DNA binding
  • DNA binding
  • sequence-specific DNA binding
  • DNA-binding transcription activator activity, RNA polymerase II-specific
  • protein binding
  • DNA-binding transcription factor activity, RNA polymerase II-specific
Cellular component
  • nucleus
Biological process
  • positive regulation of transcription, DNA-templated
  • peripheral nervous system neuron development
  • mechanosensory behavior
  • muscle organ development
  • regulation of transcription, DNA-templated
  • transcription by RNA polymerase II
  • transcription, DNA-templated
  • positive regulation of transcription by RNA polymerase II
  • axon guidance
  • regulation of transcription by RNA polymerase II
  • cell differentiation
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

2115

14009

Ensembl

ENSG00000006468

ENSMUSG00000004151

UniProt

P50549

P41164

RefSeq (mRNA)
NM_001163147
NM_001163148
NM_001163149
NM_001163150
NM_001163151

NM_001163152
NM_004956
NM_001370555
NM_001370556

NM_001163154
NM_007960
NM_001347379

RefSeq (protein)
NP_001156619
NP_001156620
NP_001156621
NP_001156622
NP_001156623

NP_001156624
NP_004947
NP_001357484
NP_001357485

NP_001156626
NP_001334308
NP_031986

Location (UCSC)Chr 7: 13.89 – 13.99 MbChr 12: 38.83 – 38.92 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

ETS translocation variant 1 is a protein that in humans is encoded by the ETV1 gene.[5][6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000006468 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000004151 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Brown TA, McKnight SL (Dec 1992). "Specificities of protein-protein and protein-DNA interaction of GABP alpha and two newly defined ets-related proteins". Genes & Development. 6 (12B): 2502–12. doi:10.1101/gad.6.12b.2502. PMID 1340465.
  6. ^ "Entrez Gene: ETV1 ets variant gene 1".

Further reading

  • Monté D, Coutte L, Baert JL, Angeli I, Stéhelin D, de Launoit Y (Aug 1995). "Molecular characterization of the ets-related human transcription factor ER81". Oncogene. 11 (4): 771–9. PMID 7651741.
  • Jeon IS, Davis JN, Braun BS, Sublett JE, Roussel MF, Denny CT, Shapiro DN (Mar 1995). "A variant Ewing's sarcoma translocation (7;22) fuses the EWS gene to the ETS gene ETV1". Oncogene. 10 (6): 1229–34. PMID 7700648.
  • Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (Apr 1996). "A "double adaptor" method for improved shotgun library construction". Analytical Biochemistry. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
  • Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (Apr 1997). "Large-scale concatenation cDNA sequencing". Genome Research. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
  • Carrère S, Verger A, Flourens A, Stehelin D, Duterque-Coquillaud M (Jun 1998). "Erg proteins, transcription factors of the Ets family, form homo, heterodimers and ternary complexes via two distinct domains". Oncogene. 16 (25): 3261–8. doi:10.1038/sj.onc.1201868. PMID 9681824. S2CID 26807714.
  • Coutte L, Monté D, Imai K, Pouilly L, Dewitte F, Vidaud M, Adamski J, Baert JL, de Launoit Y (Nov 1999). "Characterization of the human and mouse ETV1/ER81 transcription factor genes: role of the two alternatively spliced isoforms in the human". Oncogene. 18 (46): 6278–86. doi:10.1038/sj.onc.1203020. PMID 10597226.
  • Janknecht R (Nov 2001). "Cell type-specific inhibition of the ETS transcription factor ER81 by mitogen-activated protein kinase-activated protein kinase 2". The Journal of Biological Chemistry. 276 (45): 41856–61. doi:10.1074/jbc.M106630200. PMID 11551945.
  • Wu J, Janknecht R (Nov 2002). "Regulation of the ETS transcription factor ER81 by the 90-kDa ribosomal S6 kinase 1 and protein kinase A". The Journal of Biological Chemistry. 277 (45): 42669–79. doi:10.1074/jbc.M205501200. PMID 12213813.
  • Janknecht R (Feb 2003). "Regulation of the ER81 transcription factor and its coactivators by mitogen- and stress-activated protein kinase 1 (MSK1)". Oncogene. 22 (5): 746–55. doi:10.1038/sj.onc.1206185. PMID 12569367. S2CID 30183941.
  • Goel A, Janknecht R (Sep 2003). "Acetylation-mediated transcriptional activation of the ETS protein ER81 by p300, P/CAF, and HER2/Neu". Molecular and Cellular Biology. 23 (17): 6243–54. doi:10.1128/MCB.23.17.6243-6254.2003. PMC 180970. PMID 12917345.
  • Dowdy SC, Mariani A, Janknecht R (Nov 2003). "HER2/Neu- and TAK1-mediated up-regulation of the transforming growth factor beta inhibitor Smad7 via the ETS protein ER81". The Journal of Biological Chemistry. 278 (45): 44377–84. doi:10.1074/jbc.M307202200. PMID 12947087.
  • Goel A, Janknecht R (Apr 2004). "Concerted activation of ETS protein ER81 by p160 coactivators, the acetyltransferase p300 and the receptor tyrosine kinase HER2/Neu". The Journal of Biological Chemistry. 279 (15): 14909–16. doi:10.1074/jbc.M400036200. PMID 14747462.
  • Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW (Jun 2004). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nature Biotechnology. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
  • Gocke CB, Yu H, Kang J (Feb 2005). "Systematic identification and analysis of mammalian small ubiquitin-like modifier substrates". The Journal of Biological Chemistry. 280 (6): 5004–12. doi:10.1074/jbc.M411718200. PMID 15561718.

External links

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  • e
(1) Basic domains
(1.1) Basic leucine zipper (bZIP)
(1.2) Basic helix-loop-helix (bHLH)
Group A
Group B
Group C
bHLH-PAS
Group D
Group E
Group F
bHLH-COE
(1.3) bHLH-ZIP
(1.4) NF-1
(1.5) RF-X
(1.6) Basic helix-span-helix (bHSH)
(2) Zinc finger DNA-binding domains
(2.1) Nuclear receptor (Cys4)
subfamily 1
subfamily 2
subfamily 3
subfamily 4
subfamily 5
subfamily 6
subfamily 0
(2.2) Other Cys4
(2.3) Cys2His2
(2.4) Cys6
(2.5) Alternating composition
(2.6) WRKY
(3) Helix-turn-helix domains
(3.1) Homeodomain
Antennapedia
ANTP class
protoHOX
Hox-like
metaHOX
NK-like
other
(3.2) Paired box
(3.3) Fork head / winged helix
(3.4) Heat shock factors
(3.5) Tryptophan clusters
(3.6) TEA domain
  • transcriptional enhancer factor
(4) β-Scaffold factors with minor groove contacts
(4.1) Rel homology region
(4.2) STAT
(4.3) p53-like
(4.4) MADS box
(4.6) TATA-binding proteins
(4.7) High-mobility group
(4.9) Grainyhead
(4.10) Cold-shock domain
(4.11) Runt
(0) Other transcription factors
(0.2) HMGI(Y)
(0.3) Pocket domain
(0.5) AP-2/EREBP-related factors
(0.6) Miscellaneous
see also transcription factor/coregulator deficiencies