Endothelin A receptor

Protein-coding gene in the species Homo sapiens

EDNRA

Identifiers

Aliases

EDNRA, ET-A, ETA, ETA-R, ETAR, ETRA, hET-AR, MFDA, endothelin receptor type A

External IDs

OMIM: 131243 MGI: 105923 HomoloGene: 1478 GeneCards: EDNRA

Gene location (Human)

Chr.	Chromosome 4 (human)^[1]

Band	4q31.22-q31.23	Start	147,480,917 bp^[1]
Band	4q31.22-q31.23	End	147,544,954 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 8 (mouse)^[2]

Band	8\|8 C1	Start	78,389,660 bp^[2]
Band	8\|8 C1	End	78,451,093 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

seminal vesicula

visceral pleura

urethra

endometrium

caput epididymis

tibia

corpus epididymis

stromal cell of endometrium

myometrium

canal of the cervix

Top expressed in

vas deferens

external carotid artery

left lung lobe

ureter

atrium

dermis

internal carotid artery

cumulus cell

right lung lobe

belly cord

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	endothelin receptor activity G protein-coupled receptor activity signal transducer activity protein binding phosphatidylinositol phospholipase C activity
Cellular component	integral component of membrane membrane plasma membrane integral component of plasma membrane
Biological process	smooth muscle contraction response to hypoxia neural crest cell development vasoconstriction head development in utero embryonic development activation of phospholipase C activity respiratory gaseous exchange by respiratory system activation of adenylate cyclase activity regulation of blood pressure endothelin receptor signaling pathway enteric nervous system development heart development artery smooth muscle contraction branching involved in blood vessel morphogenesis cell population proliferation signal transduction positive regulation of cytosolic calcium ion concentration G protein-coupled receptor signaling pathway adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway glucose transmembrane transport regulation of glucose transmembrane transport
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


1909


13617

Ensembl


ENSG00000151617


ENSMUSG00000031616

UniProt


P25101


Q61614

RefSeq (mRNA)


NM_001166055 NM_001256283 NM_001957 NM_001354797


NM_010332

RefSeq (protein)


NP_001159527 NP_001948 NP_001341726


NP_034462

Location (UCSC)

Chr 4: 147.48 – 147.54 Mb

Chr 8: 78.39 – 78.45 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Endothelin receptor type A, also known as ET_A, is a human G protein-coupled receptor.^[5]

Interactions

Endothelin receptor type A has been shown to interact with HDAC7A^[6] and HTATIP.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000151617 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000031616 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: EDNRA endothelin receptor type A".
^ ^a ^b Lee HJ, Chun M, Kandror KV (May 2001). "Tip60 and HDAC7 interact with the endothelin receptor a and may be involved in downstream signaling". The Journal of Biological Chemistry. 276 (20): 16597–600. doi:10.1074/jbc.C000909200. PMID 11262386.

External links

"Endothelin Receptors: ET_A". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.

Arai H, Nakao K, Hosoda K, Ogawa Y, Nakagawa O, Komatsu Y, Imura H (1993). "[Molecular cloning of human endothelin receptors and their expression in vascular endothelial cells and smooth muscle cells]". Japanese Circulation Journal. 56 (Suppl 5): 1303–7. doi:10.1253/jcj.56.supplementv_1303. PMID 1291713.
Hosoda K, Nakao K, Tamura N, Arai H, Ogawa Y, Suga S, Nakanishi S, Imura H (September 1992). "Organization, structure, chromosomal assignment, and expression of the gene encoding the human endothelin-A receptor". The Journal of Biological Chemistry. 267 (26): 18797–804. doi:10.1016/S0021-9258(19)37031-0. PMID 1326535.
Hayzer DJ, Rose PM, Lynch JS, Webb ML, Kienzle BK, Liu EC, Bogosian EA, Brinson E, Runge MS (October 1992). "Cloning and expression of a human endothelin receptor: subtype A". The American Journal of the Medical Sciences. 304 (4): 231–8. doi:10.1097/00000441-199210000-00002. PMID 1415318.
Hosoda K, Nakao K, Suga S, Ogawa Y, Mukoyama M, Shirakami G, Saito Y, Nakanishi S, Imura H (August 1991). "Cloning and expression of human endothelin-1 receptor cDNA". FEBS Letters. 287 (1–2): 23–6. doi:10.1016/0014-5793(91)80007-P. PMID 1652463. S2CID 908246.
Cyr C, Huebner K, Druck T, Kris R (November 1991). "Cloning and chromosomal localization of a human endothelin ETA receptor". Biochemical and Biophysical Research Communications. 181 (1): 184–90. doi:10.1016/S0006-291X(05)81399-3. PMID 1659806.
Adachi M, Yang YY, Furuichi Y, Miyamoto C (November 1991). "Cloning and characterization of cDNA encoding human A-type endothelin receptor". Biochemical and Biophysical Research Communications. 180 (3): 1265–72. doi:10.1016/S0006-291X(05)81332-4. PMID 1719979.
Lin HY, Kaji EH, Winkel GK, Ives HE, Lodish HF (April 1991). "Cloning and functional expression of a vascular smooth muscle endothelin 1 receptor". Proceedings of the National Academy of Sciences of the United States of America. 88 (8): 3185–9. Bibcode:1991PNAS...88.3185L. doi:10.1073/pnas.88.8.3185. PMC 51410. PMID 1849646.
Takigawa M, Sakurai T, Kasuya Y, Abe Y, Masaki T, Goto K (February 1995). "Molecular identification of guanine-nucleotide-binding regulatory proteins which couple to endothelin receptors". European Journal of Biochemistry. 228 (1): 102–8. doi:10.1111/j.1432-1033.1995.tb20236.x. PMID 7882989.
Kobayashi S, Tang R, Wang B, Opgenorth T, Langenstroer P, Shapiro E, Lepor H (February 1994). "Binding and functional properties of endothelin receptor subtypes in the human prostate". Molecular Pharmacology. 45 (2): 306–11. PMID 8114678.
Yang H, Tabuchi H, Furuichi Y, Miyamoto C (January 1993). "Molecular characterization of the 5'-flanking region of human genomic ETA gene". Biochemical and Biophysical Research Communications. 190 (2): 332–9. doi:10.1006/bbrc.1993.1052. PMID 8427579.
Elshourbagy NA, Korman DR, Wu HL, Sylvester DR, Lee JA, Nuthalaganti P, Bergsma DJ, Kumar CS, Nambi P (February 1993). "Molecular characterization and regulation of the human endothelin receptors". The Journal of Biological Chemistry. 268 (6): 3873–9. doi:10.1016/S0021-9258(18)53554-7. PMID 8440682.
Miyamoto Y, Yoshimasa T, Arai H, Takaya K, Ogawa Y, Itoh H, Nakao K (February 1996). "Alternative RNA splicing of the human endothelin-A receptor generates multiple transcripts". The Biochemical Journal. 313 (3): 795–801. doi:10.1042/bj3130795. PMC 1216980. PMID 8611157.
Horstmeyer A, Cramer H, Sauer T, Müller-Esterl W, Schroeder C (August 1996). "Palmitoylation of endothelin receptor A. Differential modulation of signal transduction activity by post-translational modification". The Journal of Biological Chemistry. 271 (34): 20811–9. doi:10.1074/jbc.271.34.20811. PMID 8702836.
Freedman NJ, Ament AS, Oppermann M, Stoffel RH, Exum ST, Lefkowitz RJ (July 1997). "Phosphorylation and desensitization of human endothelin A and B receptors. Evidence for G protein-coupled receptor kinase specificity". The Journal of Biological Chemistry. 272 (28): 17734–43. doi:10.1074/jbc.272.28.17734. PMID 9211925.
Bourgeois C, Robert B, Rebourcet R, Mondon F, Mignot TM, Duc-Goiran P, Ferré F (September 1997). "Endothelin-1 and ETA receptor expression in vascular smooth muscle cells from human placenta: a new ETA receptor messenger ribonucleic acid is generated by alternative splicing of exon 3". The Journal of Clinical Endocrinology and Metabolism. 82 (9): 3116–23. doi:10.1210/jcem.82.9.4209. PMID 9284755.
Mao XQ, Gao PS, Roberts MH, Enomoto T, Kawai M, Sasaki S, Shaldon SR, Coull P, Dake Y, Adra CN, Hagihara A, Shirakawa T, Hopkin JM (August 1999). "Variants of endothelin-1 and its receptors in atopic asthma". Biochemical and Biophysical Research Communications. 262 (1): 259–62. doi:10.1006/bbrc.1999.1158. PMID 10448102.
Maggi M, Barni T, Fantoni G, Mancina R, Pupilli C, Luconi M, Crescioli C, Serio M, Vannelli GB (April 2000). "Expression and biological effects of endothelin-1 in human gonadotropin-releasing hormone-secreting neurons". The Journal of Clinical Endocrinology and Metabolism. 85 (4): 1658–65. doi:10.1210/jcem.85.4.6565. PMID 10770212. S2CID 22812539.
Shraga-Levine Z, Sokolovsky M (June 2000). "Functional coupling of G proteins to endothelin receptors is ligand and receptor subtype specific". Cellular and Molecular Neurobiology. 20 (3): 305–17. doi:10.1023/A:1007010125316. PMID 10789830. S2CID 21841332.
Lee HJ, Chun M, Kandror KV (May 2001). "Tip60 and HDAC7 interact with the endothelin receptor a and may be involved in downstream signaling". The Journal of Biological Chemistry. 276 (20): 16597–600. doi:10.1074/jbc.C000909200. PMID 11262386.
Paasche JD, Attramadal T, Sandberg C, Johansen HK, Attramadal H (September 2001). "Mechanisms of endothelin receptor subtype-specific targeting to distinct intracellular trafficking pathways". The Journal of Biological Chemistry. 276 (36): 34041–50. doi:10.1074/jbc.M103243200. PMID 11382773.
Davenport AP, Hyndman KA, Dhaun N, Southan C, Kohan DE, Pollock JS, Pollock DM, Webb DJ, Maguire JJ (April 2016). "Endothelin". Pharmacological Reviews. 68 (2): 357–418. doi:10.1124/pr.115.011833. PMC 4815360. PMID 26956245.
Han SG, Ko S, Lee WK, Jung ST, Yu YG (August 2017). "Determination of the endothelin-1 recognition sites of endothelin receptor type A by the directed-degeneration method". Scientific Reports. 7 (1): 7577. Bibcode:2017NatSR...7.7577H. doi:10.1038/s41598-017-08096-6. PMC 5548930. PMID 28790412.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Cell surface receptor: G protein-coupled receptors

Class A: Rhodopsin-like

Neurotransmitter

Adrenergic	α1 (A B D) α2 (A B C) β1 β2 β3
Purinergic	Adenosine (A1 A2A A2B A3) P2Y (1 2 4 5 6 8 9 10 11 12 13 14)
Serotonin	(all but 5-HT3) 5-HT1 (A B D E F) 5-HT2 (A B C) 5-HT (4 5A 6 7)
Other	Acetylcholine (M1 M2 M3 M4 M5) Dopamine D1 D2 D3 D4 D5 GHB receptor Histamine H1 H2 H3 H4 Melatonin (1A 1B 1C) TAAR (1 2 5 6 8 9)

Metabolites and
signaling molecules

Eicosanoid	CysLT (1 2) LTB4 1 2 FPRL1 OXE Prostaglandin DP (1 2), EP (1 2 3 4), FP Prostacyclin Thromboxane
Other	Bile acid Cannabinoid (CB1 CB2, GPR (18 55 119)) EBI2 Estrogen Free fatty acid (1 2 3 4) Hydroxycarboxylic acids 1 2 3 Lysophosphatidic acid (1 2 3 4 5 6) Lysophospholipid (1 2 3 4 5 6 7 8) Oxoglutarate PAF Sphingosine-1-phosphate (1 2 3 4 5) Succinate

Peptide

Neuropeptide

B/W (1
2)
FF (1
2)
S
Y (1
2
4
5)
Neuromedin (B
U (1
2))
Neurotensin (1
2)

Other

Anaphylatoxin (C3a
C5a (1
2))
Angiotensin (1
2)
Apelin
Bombesin
- BRS3
- GRPR
- NMBR)
- Bradykinin (B1
- B2)
Chemokine
Cholecystokinin (A
B)
Endothelin
- A
- B
Formyl peptide (1
2
3)
FSH
Galanin (1
2
3)
Gonadotropin-releasing hormone (1
2)
Ghrelin
Kisspeptin
Luteinizing hormone/choriogonadotropin
MAS (1
1L
D
E
F
G
X1
X2
X3
X4)
Melanocortin (1
2
3
4
5)
MCHR (1
2)
Motilin
Opioid (Delta
Kappa
Mu
Nociceptin & Zeta, but not Sigma)
Orexin (1
2)
Oxytocin
Prokineticin (1
2)
Prolactin-releasing peptide
Relaxin (1
2
3
4)
Somatostatin (1
2
3
4
5)
Tachykinin (1
2
3)
Thyrotropin
Thyrotropin-releasing hormone
Urotensin-II
Vasopressin (1A
1B
2)

Miscellaneous

Taste, bitter	TAS2R 1 3 4 5 7 8 9 10 13 14 16 19 20 30 31 38 39 40 41 42 43 45 46 50 60 Vomeronasal receptor type 1
Orphan	GPR (1 3 4 6 12 15 17 18 19 20 21 22 23 25 26 27 31 32 33 34 35 37 39 42 44 45 50 52 55 61 62 63 65 68 75 78 81 82 83 84 85 87 88 92 101 103 109A 109B 119 120 132 135 137B 139 141 142 146 148 149 150 151 152 153 160 161 162 171 173 174 176 177 182 183)
Other	Adrenomedullin Olfactory Opsin (3 4 5 1LW 1MW 1SW RGR RRH) Protease-activated (1 2 3 4) SREB (1 2 3)

Class B: Secretin-like

Adhesion	ADGRB Brain-specific angiogenesis inhibitor 1 2 3 ADGRC Cadherin 1 2 3 ADGRE EMR 1 2 3 CD97 ADGRG 1 2 3 4 5 6 7 ADGRL Latrophilin 1 2 3 ELTD1
Orphan	GPR (56 64 97 98 110 111 112 113 114 115 116 123 124 125 126 128 133 143 144 155 157)
Other	Calcitonin CALCRL Corticotropin-releasing hormone (1 2) Glucagon (GR GIPR GLP1R GLP2R) Growth-hormone-releasing hormone PACAPR1 GPR Methuselah-like proteins Parathyroid hormone (1 2) Secretin Vasoactive intestinal peptide (1 2)

Class C: Metabotropic glutamate / pheromone

Taste, sweet	TAS1R 1 2 3 Vomeronasal receptor, type 2
Other	Calcium-sensing receptor GABA_B (1 2) Glutamate receptor (Metabotropic glutamate (1 2 3 4 5 6 7 8)) GPRC6A GPR (156 158 179) RAIG (1 2 3 4)