Excitatory amino acid transporter 4

Protein found in humans
SLC1A6
Identifiers
AliasesSLC1A6, EAAT4, solute carrier family 1 member 6
External IDsOMIM: 600637 MGI: 1096331 HomoloGene: 21055 GeneCards: SLC1A6
Gene location (Human)
Chromosome 19 (human)
Chr.Chromosome 19 (human)[1]
Chromosome 19 (human)
Genomic location for SLC1A6
Genomic location for SLC1A6
Band19p13.12Start14,950,033 bp[1]
End15,022,990 bp[1]
Gene location (Mouse)
Chromosome 10 (mouse)
Chr.Chromosome 10 (mouse)[2]
Chromosome 10 (mouse)
Genomic location for SLC1A6
Genomic location for SLC1A6
Band10 C1|10 39.72 cMStart78,616,330 bp[2]
End78,650,599 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • endothelial cell

  • cerebellar vermis

  • nucleus accumbens

  • oocyte

  • caudate nucleus

  • prefrontal cortex

  • putamen

  • sperm

  • cingulate gyrus

  • dorsolateral prefrontal cortex
Top expressed in
  • cerebellar vermis

  • dorsomedial hypothalamic nucleus

  • ventromedial nucleus

  • inferior colliculus

  • superior colliculus

  • lateral hypothalamus

  • ventral tegmental area

  • paraventricular nucleus of hypothalamus

  • dorsal tegmental nucleus

  • suprachiasmatic nucleus
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • L-aspartate transmembrane transporter activity
  • symporter activity
  • L-glutamate transmembrane transporter activity
  • amino acid transmembrane transporter activity
  • high-affinity glutamate transmembrane transporter activity
  • metal ion binding
Cellular component
  • integral component of membrane
  • Golgi apparatus
  • membrane
  • intermediate filament cytoskeleton
  • integral component of plasma membrane
  • plasma membrane
  • glutamatergic synapse
  • integral component of presynaptic membrane
Biological process
  • chemical synaptic transmission
  • regulation of membrane potential
  • ion transport
  • glutamate secretion
  • aspartate transmembrane transport
  • L-glutamate transmembrane transport
  • L-glutamate import across plasma membrane
  • amino acid transport
  • L-aspartate transmembrane transport
  • neurotransmitter uptake
  • transmembrane transport
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

6511

20513

Ensembl

ENSG00000105143

ENSMUSG00000005357

UniProt

P48664

O35544

RefSeq (mRNA)
NM_001272087
NM_001272088
NM_005071
NM_001384669
NM_001384670

NM_001384671

NM_009200

RefSeq (protein)

NP_001259016
NP_001259017
NP_005062

NP_033226

Location (UCSC)Chr 19: 14.95 – 15.02 MbChr 10: 78.62 – 78.65 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Excitatory amino-acid transporter 4 (EAAT4) is a protein that in humans is encoded by the SLC1A6 gene.[5][6]

EAAT4 is expressed predominantly in the cerebellum, has high affinity for the excitatory amino acids L-aspartate and L-glutamate. When stimulated by these amino acids, EAAT4 conducts chloride ions.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000105143 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000005357 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: solute carrier family 1 (high affinity aspartate/glutamate transporter)".
  6. ^ a b Fairman WA, Vandenberg RJ, Arriza JL, Kavanaugh MP, Amara SG (June 1995). "An excitatory amino-acid transporter with properties of a ligand-gated chloride channel". Nature. 375 (6532): 599–603. Bibcode:1995Natur.375..599F. doi:10.1038/375599a0. PMID 7791878. S2CID 4334983.

Further reading

  • Deng X, Shibata H, Takeuchi N, et al. (2007). "Association study of polymorphisms in the glutamate transporter genes SLC1A1, SLC1A3, and SLC1A6 with schizophrenia". Am. J. Med. Genet. B Neuropsychiatr. Genet. 144B (3): 271–8. doi:10.1002/ajmg.b.30351. PMID 17221839. S2CID 42347750.
  • Need AC, Keefe RS, Ge D, et al. (2009). "Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis". Eur. J. Hum. Genet. 17 (7): 946–57. doi:10.1038/ejhg.2008.264. PMC 2986499. PMID 19156168.
  • Poulsen MV, Vandenberg RJ (2001). "Niflumic acid modulates uncoupled substrate-gated conductances in the human glutamate transporter EAAT4". J. Physiol. 534 (Pt 1): 159–67. doi:10.1111/j.1469-7793.2001.00159.x. PMC 2278676. PMID 11432999.
  • Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923.
  • Koch HP, Brown RL, Larsson HP (2007). "The glutamate-activated anion conductance in excitatory amino acid transporters is gated independently by the individual subunits". J. Neurosci. 27 (11): 2943–7. doi:10.1523/JNEUROSCI.0118-07.2007. PMC 2435202. PMID 17360917.
  • Jackson M, Song W, Liu MY, et al. (2001). "Modulation of the neuronal glutamate transporter EAAT4 by two interacting proteins". Nature. 410 (6824): 89–93. doi:10.1038/35065091. PMID 11242047. S2CID 4381210.
  • Rajamanickam J, Palmada M, Lang F, Boehmer C (2007). "EAAT4 phosphorylation at the SGK1 consensus site is required for transport modulation by the kinase". J. Neurochem. 102 (3): 858–66. doi:10.1111/j.1471-4159.2007.04585.x. PMID 17442044. S2CID 30779935.
  • Gratacòs M, Costas J, de Cid R, et al. (2009). "Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment". Am. J. Med. Genet. B Neuropsychiatr. Genet. 150B (6): 808–16. doi:10.1002/ajmg.b.30902. PMID 19086053. S2CID 44524739.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19" (PDF). Nature. 428 (6982): 529–35. Bibcode:2004Natur.428..529G. doi:10.1038/nature02399. PMID 15057824. S2CID 4420825.
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By group
SLC1–10
(1):
(2):
(3):
(4):
(5):
(6):
(7):
(8):
  • Na+/Ca2+ exchanger
(9):
(10):
SLC11–20
(11):
(12):
(13):
(14):
(15):
(16):
(17):
(18):
(19):
(20):
SLC21–30
(21):
(22):
(23):
  • Na+-dependent ascorbic acid transporter
(24):
  • Na+/(Ca2+-K+) exchanger
(25):
(26):
(27):
(28):
(29):
(30):
SLC31–40
(31):
(32):
(33):
(34):
(35):
(36):
(37):
(38):
(39):
(40):
  • basolateral iron transporter
SLC41–48
(41):
(42):
(43):
  • Na+-independent, system-L like amino-acid transporter
(44):
(45):
(46):
(47):
(48):
SLCO1–4
Symporter, Cotransporter
  • Na+/K+,Cl−
  • Na+/Pi3
  • Na+/Cl−
  • Na+/glucose
  • Na+/I−
  • Cl−/K+
Antiporter (exchanger)
  • Na+/H+
  • Na+/Ca2+
    • Na+/(Ca2+-K+) - Cl−/HCO−
      3       (Band 3)
  • Cl−-formate
  • Cl−-oxalate
see also solute carrier disorders
  • v
  • t
  • e
Transporter
EAATsTooltip Excitatory amino acid transporters
vGluTsTooltip Vesicular glutamate transporters
Enzyme
GAHTooltip Glutamine aminohydrolase (glutaminase)
  • BPTES
  • CB-839
  • DON
ASTTooltip Aspartate aminotransferase
  • 2-Amino-3-butenoic acid
  • AAOA
  • AMB
  • β-DL-Methylene-aspartate
  • Hydrazinosuccinate
ALTTooltip Alanine aminotransferase
  • β-Chloro-L-alanine
  • L-Cycloserine
  • Propargylglycine
GDHTooltip Glutamate dehydrogenase
GSTooltip Glutamine synthetase
GADTooltip Glutamate decarboxylase
See also: Receptor/signaling modulators • Ionotropic glutamate receptor modulators • Metabotropic glutamate receptor modulators • GABA metabolism and transport modulators


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