Excitatory amino acid transporter 5

Protein found in humans
SLC1A7
Identifiers
AliasesSLC1A7, AAAT, EAAT5, solute carrier family 1 member 7
External IDsOMIM: 604471 MGI: 2444087 HomoloGene: 21327 GeneCards: SLC1A7
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for SLC1A7
Genomic location for SLC1A7
Band1p32.3Start53,087,179 bp[1]
End53,142,638 bp[1]
Gene location (Mouse)
Chromosome 4 (mouse)
Chr.Chromosome 4 (mouse)[2]
Chromosome 4 (mouse)
Genomic location for SLC1A7
Genomic location for SLC1A7
Band4|4 C7Start107,825,529 bp[2]
End107,870,729 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • gastric mucosa

  • jejunal mucosa

  • gallbladder

  • tibial nerve

  • right coronary artery

  • left uterine tube

  • duodenum

  • left coronary artery

  • canal of the cervix

  • ascending aorta
Top expressed in
  • outer nuclear layer

  • retinal pigment epithelium

  • inner nuclear layer

  • left lobe of liver

  • spermatid

  • skin of abdomen

  • pituitary gland

  • testicle

  • carotid body

  • heart
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • symporter activity
  • L-glutamate transmembrane transporter activity
  • amino acid transmembrane transporter activity
  • high-affinity glutamate transmembrane transporter activity
Cellular component
  • integral component of membrane
  • plasma membrane
  • membrane
  • presynapse
Biological process
  • glutamate secretion
  • ion transport
  • dicarboxylic acid transport
  • transmembrane transport
  • amino acid transmembrane transport
  • L-glutamate transmembrane transport
  • neurotransmitter uptake
  • neurotransmitter reuptake
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

6512

242607

Ensembl

ENSG00000162383

ENSMUSG00000008932

UniProt

O00341

Q8JZR4

RefSeq (mRNA)

NM_001287595
NM_001287596
NM_001287597
NM_006671

NM_146255

RefSeq (protein)

NP_001274524
NP_001274525
NP_001274526
NP_006662

NP_666367

Location (UCSC)Chr 1: 53.09 – 53.14 MbChr 4: 107.83 – 107.87 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Excitatory amino-acid transporter 5 (EAAT5) is a protein that in humans is encoded by the SLC1A7 gene.[5][6]

EAAT5 is expressed predominantly in the retina, has high affinity for the excitatory amino acid L-glutamate. When stimulated by this amino acid, EAAT5 conducts chloride ions.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000162383 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000008932 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: solute carrier family 1 (glutamate transporter)".
  6. ^ a b Arriza JL, Eliasof S, Kavanaugh MP, Amara SG (April 1997). "Excitatory amino acid transporter 5, a retinal glutamate transporter coupled to a chloride conductance". Proc. Natl. Acad. Sci. U.S.A. 94 (8): 4155–60. Bibcode:1997PNAS...94.4155A. doi:10.1073/pnas.94.8.4155. PMC 20584. PMID 9108121.

Further reading

  • Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Wistow G, Bernstein SL, Ray S, et al. (2002). "Expressed sequence tag analysis of adult human iris for the NEIBank Project: steroid-response factors and similarities with retinal pigment epithelium". Mol. Vis. 8: 185–95. PMID 12107412.
  • Boehmer C, Rajamanickam J, Schniepp R, et al. (2005). "Regulation of the excitatory amino acid transporter EAAT5 by the serum and glucocorticoid dependent kinases SGK1 and SGK3". Biochem. Biophys. Res. Commun. 329 (2): 738–42. doi:10.1016/j.bbrc.2005.02.035. PMID 15737648.
  • Gratacòs M, Costas J, de Cid R, et al. (2009). "Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment". Am. J. Med. Genet. B Neuropsychiatr. Genet. 150B (6): 808–16. doi:10.1002/ajmg.b.30902. PMID 19086053. S2CID 44524739.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • v
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By group
SLC1–10
(1):
(2):
(3):
(4):
(5):
(6):
(7):
(8):
  • Na+/Ca2+ exchanger
(9):
(10):
SLC11–20
(11):
(12):
(13):
(14):
(15):
(16):
(17):
(18):
(19):
(20):
SLC21–30
(21):
(22):
(23):
  • Na+-dependent ascorbic acid transporter
(24):
  • Na+/(Ca2+-K+) exchanger
(25):
(26):
(27):
(28):
(29):
(30):
SLC31–40
(31):
(32):
(33):
(34):
(35):
(36):
(37):
(38):
(39):
(40):
  • basolateral iron transporter
SLC41–48
(41):
(42):
(43):
  • Na+-independent, system-L like amino-acid transporter
(44):
(45):
(46):
(47):
(48):
SLCO1–4
Symporter, Cotransporter
  • Na+/K+,Cl−
  • Na+/Pi3
  • Na+/Cl−
  • Na+/glucose
  • Na+/I−
  • Cl−/K+
Antiporter (exchanger)
  • Na+/H+
  • Na+/Ca2+
    • Na+/(Ca2+-K+) - Cl−/HCO−
      3       (Band 3)
  • Cl−-formate
  • Cl−-oxalate
see also solute carrier disorders
  • v
  • t
  • e
Transporter
EAATsTooltip Excitatory amino acid transporters
vGluTsTooltip Vesicular glutamate transporters
Enzyme
GAHTooltip Glutamine aminohydrolase (glutaminase)
  • BPTES
  • CB-839
  • DON
ASTTooltip Aspartate aminotransferase
  • 2-Amino-3-butenoic acid
  • AAOA
  • AMB
  • β-DL-Methylene-aspartate
  • Hydrazinosuccinate
ALTTooltip Alanine aminotransferase
  • β-Chloro-L-alanine
  • L-Cycloserine
  • Propargylglycine
GDHTooltip Glutamate dehydrogenase
GSTooltip Glutamine synthetase
GADTooltip Glutamate decarboxylase
See also: Receptor/signaling modulators • Ionotropic glutamate receptor modulators • Metabotropic glutamate receptor modulators • GABA metabolism and transport modulators


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