FGF1

FGF1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4QO3, 1AXM, 1DJS, 1DZC, 1DZD, 1E0O, 1EVT, 1HKN, 1JQZ, 1JT3, 1JT4, 1JT5, 1JT7, 1JTC, 1JY0, 1K5U, 1K5V, 1M16, 1NZK, 1P63, 1PZZ, 1Q03, 1Q04, 1RG8, 1RML, 1RY7, 1YTO, 1Z2V, 1Z4S, 2AFG, 2AQZ, 2AXM, 2ERM, 2HW9, 2HWA, 2HWM, 2HZ9, 2K43, 2K4A, 2K8R, 2KI4, 2KI6, 2NTD, 2Q9X, 2RQ9, 3B9U, 3BA4, 3BA5, 3BA7, 3BAD, 3BAG, 3BAH, 3BAO, 3BAQ, 3BAU, 3BAV, 3BB2, 3CQA, 3CRG, 3CRH, 3CRI, 3CU1, 3FGM, 3FJ8, 3FJ9, 3FJA, 3FJB, 3FJC, 3FJD, 3FJE, 3FJF, 3FJH, 3FJI, 3FJJ, 3FJK, 3HOM, 3JUT, 3K1X, 3O3Q, 3OJ2, 3OJM, 3OJV, 3UD7, 3UD8, 3UD9, 3UDA, 4J23, 4Q91, 4Q9G, 4Q9P, 4QAL, 4QBC, 4QBV, 4QC4, 4XKI, 4YOL
Identifiers
Aliases	FGF1, AFGF, ECGF, ECGF-beta, ECGFA, ECGFB, FGF-1, FGF-alpha, FGFA, GLIO703, HBGF-1, HBGF1, fibroblast growth factor 1
External IDs	OMIM: 131220 MGI: 95515 HomoloGene: 625 GeneCards: FGF1
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q31.3 Start 142,592,178 bp[1] End 142,698,070 bp[1]
Gene location (Mouse) Chr. Chromosome 18 (mouse)[2] Band 18 B3|18 20.74 cM Start 38,971,726 bp[2] End 39,062,525 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in glomerulus metanephric glomerulus inferior ganglion of vagus nerve corpus callosum optic nerve external globus pallidus internal globus pallidus medulla oblongata inferior olivary nucleus olfactory bulb Top expressed in pontine nuclei medial vestibular nucleus habenula facial motor nucleus dorsal tegmental nucleus anterior horn of spinal cord right lung myocardium of ventricle right ventricle ventral tegmental area More reference expression data BioGPS More reference expression data
Gene ontology Molecular function S100 protein binding protein binding growth factor activity protein tyrosine kinase activity phosphatidylinositol-4,5-bisphosphate 3-kinase activity fibroblast growth factor receptor binding integrin binding 1-phosphatidylinositol-3-kinase activity heparin binding Hsp70 protein binding Cellular component cytoplasm cytosol extracellular region cell cortex nucleolus nucleus extracellular space extracellular matrix Biological process cell differentiation cellular response to heat positive regulation of protein phosphorylation positive regulation of MAP kinase activity organ induction lung development positive regulation of epithelial cell proliferation anatomical structure morphogenesis positive regulation of intracellular signal transduction branch elongation involved in ureteric bud branching positive regulation of angiogenesis MAPK cascade multicellular organism development mesonephric epithelium development angiogenesis regulation of endothelial cell chemotaxis to fibroblast growth factor positive regulation of cholesterol biosynthetic process cell population proliferation positive regulation of cell division positive regulation of transcription by RNA polymerase II signal transduction phosphatidylinositol phosphate biosynthetic process peptidyl-tyrosine phosphorylation positive regulation of sprouting angiogenesis fibroblast growth factor receptor signaling pathway positive regulation of cell population proliferation phosphatidylinositol-3-phosphate biosynthetic process regulation of endothelial tube morphogenesis positive regulation of cell migration positive regulation of endothelial cell migration activation of protein kinase B activity regulation of signaling receptor activity positive regulation of protein kinase B signaling Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2246 14164 Ensembl ENSG00000113578 ENSMUSG00000036585 UniProt P05230 P61148 RefSeq (mRNA) NM_000800 NM_001144892 NM_001144934 NM_001144935 NM_001257205 NM_001257206 NM_001257207 NM_001257208 NM_001257209 NM_001257210 NM_001257211 NM_001257212 NM_033136 NM_033137 NM_001354955 NM_001354956 NM_001354957 NM_001354958 NM_001354959 NM_001354961 NM_001354963 NM_001354964 NM_001354951 NM_001354952 NM_001354953 NM_001354954 NM_001354962 NM_010197 RefSeq (protein) NP_000791 NP_001138364 NP_001138406 NP_001138407 NP_001244134 NP_001244135 NP_001244136 NP_001244137 NP_001244138 NP_001244139 NP_001244140 NP_001244141 NP_149127 NP_149128 NP_001341884 NP_001341885 NP_001341886 NP_001341887 NP_001341888 NP_001341890 NP_001341892 NP_001341893 NP_001341880 NP_001341881 NP_001341882 NP_001341883 NP_001341891 NP_034327 Location (UCSC) Chr 5: 142.59 – 142.7 Mb Chr 18: 38.97 – 39.06 Mb PubMed search [3] [4]
Wikidata
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Fibroblast growth factor 1, (FGF-1) also known as acidic fibroblast growth factor (aFGF), is a growth factor and signaling protein encoded by the FGF1 gene.^[5][6] It is synthesized as a 155 amino acid polypeptide, whose mature form is a non-glycosylated 17-18 kDa protein. Fibroblast growth factor protein was first purified in 1975, but soon afterwards others using different conditions isolated acidic FGF, Heparin-binding growth factor-1, and Endothelial cell growth factor-1.^[7] Gene sequencing revealed that this group was actually the same growth factor and that FGF1 was a member of a family of FGF proteins.

FGF-1 has no definitive signal sequence and thus is not secreted through classical pathways, but it does appear to form a disulfide linked dimer inside cells that associate with a complex of proteins at the cell membrane (including S100A13 and Syt1) which then help flip it through the membrane to the exterior of the cell.^[8][9] Once in the reducing conditions of the surrounding tissue, the dimer dissociates into monomeric FGF1 that can enter systemic circulation or be sequestered in tissues binding to heparan sulfate proteoglycans of the extracellular matrix. FGF1 can then bind to and exert its effects via specific fibroblast growth factor receptor (FGFR) proteins which themselves constitute a family of closely related molecules.^[10]

In addition to its extracellular activity, FGF1 can also function intracellularly. The protein has a nuclear localization sequence (NLS) but the route that FGF1 takes to get to the nucleus is unclear and it appears that some sort of cell surface receptor binding is necessary, followed by its internalization and translocation to the nucleus whereupon it can interact with nuclear isoforms of FGFRs.^[10] This is different from FGF2 which also can activate nuclear FGFRs but has splicing variants of the protein that never leave the cell and go directly to the nucleus.^{[citation needed]}

Function

FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein functions as a modifier of endothelial cell migration and proliferation, as well as an angiogenic factor. It acts as a mitogen for a variety of mesoderm- and neuroectoderm-derived cells in vitro, thus is thought to be involved in organogenesis. Three alternatively spliced variants encoding different isoforms have been described.^[11]

FGF1 is multifunctional with many reported effects. For one example, in mice with diet-induced diabetes that is an experimental equivalent of type 2 diabetes in humans, a single injection of the FGF1 protein is enough to restore blood sugar levels to a healthy range for > 2 days.^[12]

Interactions

FGF1 has been shown to interact with:

See also

• Fibroblast growth factor

References

Further reading