FKBP3

Protein-coding gene in the species Homo sapiens
FKBP3
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

1PBK, 2KFV, 2MPH, 5D75

Identifiers
AliasesFKBP3, FKBP-25, FKBP-3, FKBP25, PPIase, FK506 binding protein 3, FKBP prolyl isomerase 3
External IDsOMIM: 186947 MGI: 1353460 HomoloGene: 1525 GeneCards: FKBP3
Gene location (Human)
Chromosome 14 (human)
Chr.Chromosome 14 (human)[1]
Chromosome 14 (human)
Genomic location for FKBP3
Genomic location for FKBP3
Band14q21.2Start45,115,599 bp[1]
End45,135,319 bp[1]
Gene location (Mouse)
Chromosome 12 (mouse)
Chr.Chromosome 12 (mouse)[2]
Chromosome 12 (mouse)
Genomic location for FKBP3
Genomic location for FKBP3
Band12|12 C1Start65,109,198 bp[2]
End65,120,781 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • vastus lateralis muscle

  • Brodmann area 23

  • body of tongue

  • gastrocnemius muscle

  • sperm

  • thoracic diaphragm

  • right ventricle

  • triceps brachii muscle

  • Brodmann area 9

  • cerebellar hemisphere
Top expressed in
  • medial vestibular nucleus

  • mammillary body

  • lateral hypothalamus

  • intercostal muscle

  • ventromedial nucleus

  • dorsomedial hypothalamic nucleus

  • paraventricular nucleus of hypothalamus

  • condyle

  • fossa

  • lateral geniculate nucleus
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • isomerase activity
  • FK506 binding
  • peptidyl-prolyl cis-trans isomerase activity
  • protein binding
  • RNA binding
  • signaling receptor activity
Cellular component
  • nucleus
  • cytoplasm
Biological process
  • chaperone-mediated protein folding
  • protein peptidyl-prolyl isomerization
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

2287

30795

Ensembl

ENSG00000100442

ENSMUSG00000020949

UniProt

Q00688

Q62446

RefSeq (mRNA)

NM_002013

NM_013902

RefSeq (protein)

NP_002004

NP_038930

Location (UCSC)Chr 14: 45.12 – 45.14 MbChr 12: 65.11 – 65.12 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

FK506-binding protein 3 also known as FKBP25 is a protein that in humans is encoded by the FKBP3 gene.[5][6][7]

Function

The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It has a higher affinity for rapamycin than for FK506 and thus may be an important target molecule for immunosuppression by rapamycin.[8][7]

Interactions

FKBP3 has been shown to interact with YY1,[9] HDAC1,[9] Histone deacetylase 2,[9] DNA,[10] and Mdm2.[11] Both crystal structure of FKBP25 with FK506 and the NMR structure of full length FKBP25 has been published with PDB ID 5D75 and 2MPH respectively.[8][12]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000100442 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020949 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Hung DT, Schreiber SL (Jun 1992). "cDNA cloning of a human 25 kDa FK506 and rapamycin binding protein". Biochem. Biophys. Res. Commun. 184 (2): 733–8. doi:10.1016/0006-291X(92)90651-Z. PMID 1374240.
  6. ^ Porat R, Poutsiaka DD, Miller LC, Granowitz EV, Dinarello CA (May 1992). "Interleukin-1 (IL-1) receptor blockade reduces endotoxin and Borrelia burgdorferi-stimulated IL-8 synthesis in human mononuclear cells". FASEB J. 6 (7): 2482–6. doi:10.1096/fasebj.6.7.1532945. PMID 1532945. S2CID 29899093.
  7. ^ a b "Entrez Gene: FKBP3 FK506 binding protein 3, 25kDa".
  8. ^ a b Prakash A, Rajan S, Yoon HS (April 2016). "Crystal structure of the FK506 binding domain of human FKBP25 in complex with FK506". Protein Science. 25 (4): 905–910. doi:10.1002/pro.2875. ISSN 1469-896X. PMC 4941220. PMID 26749369.
  9. ^ a b c Yang WM, Yao YL, Seto E (Sep 2001). "The FK506-binding protein 25 functionally associates with histone deacetylases and with transcription factor YY1". EMBO J. 20 (17): 4814–25. doi:10.1093/emboj/20.17.4814. PMC 125595. PMID 11532945.
  10. ^ Prakash A, Shin J, Rajan S, Yoon HS (2016). "Structural basis of nucleic acid recognition by FK506-binding protein 25 (FKBP25), a nuclear immunophilin". Nucleic Acids Res. 44 (6): 2909–25. doi:10.1093/nar/gkw001. PMC 4824100. PMID 26762975.
  11. ^ Ochocka AM, Kampanis P, Nicol S, Allende-Vega N, Cox M, Marcar L, Milne D, Fuller-Pace F, Meek D (Feb 2009). "FKBP25, a novel regulator of the p53 pathway, induces the degradation of MDM2 and activation of p53". FEBS Lett. 583 (4): 621–6. doi:10.1016/j.febslet.2009.01.009. PMID 19166840. S2CID 6110.
  12. ^ Prakash A, Shin J, Rajan S, Yoon HS (2016-04-07). "Structural basis of nucleic acid recognition by FK506-binding protein 25 (FKBP25), a nuclear immunophilin". Nucleic Acids Research. 44 (6): 2909–2925. doi:10.1093/nar/gkw001. ISSN 0305-1048. PMC 4824100. PMID 26762975.

Further reading

  • Jin YJ, Burakoff SJ, Bierer BE (1992). "Molecular cloning of a 25-kDa high affinity rapamycin binding protein, FKBP25". J. Biol. Chem. 267 (16): 10942–5. doi:10.1016/S0021-9258(19)49856-6. PMID 1375932.
  • Wiederrecht G, Martin MM, Sigal NH, Siekierka JJ (1992). "Isolation of a human cDNA encoding a 25 kDa FK-506 and rapamycin binding protein". Biochem. Biophys. Res. Commun. 185 (1): 298–303. doi:10.1016/S0006-291X(05)80990-8. PMID 1376117.
  • Jin YJ, Burakoff SJ (1993). "The 25-kDa FK506-binding protein is localized in the nucleus and associates with casein kinase II and nucleolin". Proc. Natl. Acad. Sci. U.S.A. 90 (16): 7769–73. Bibcode:1993PNAS...90.7769J. doi:10.1073/pnas.90.16.7769. PMC 47224. PMID 7689229.
  • Cross SH, Charlton JA, Nan X, Bird AP (1994). "Purification of CpG islands using a methylated DNA binding column". Nat. Genet. 6 (3): 236–44. doi:10.1038/ng0394-236. PMID 8012384. S2CID 12847618.
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Meng X, Chen J, Yang Q, Wang S, Chao Y, Ying K, Xie Y, Mao Y (2002). "Cloning and identification of a novel cDNA which may be associated with FKBP25". Biochem. Genet. 40 (9–10): 303–10. doi:10.1023/A:1020256718720. PMID 12392168. S2CID 24265377.
  • Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

External links

  • PDBe-KB provides an overview of all the structure information available in the PDB for Human Peptidyl-prolyl cis-trans isomerase FKBP3
  • PDBe-KB provides an overview of all the structure information available in the PDB for Mouse Peptidyl-prolyl cis-trans isomerase FKBP3
  • v
  • t
  • e
  • 1pbk: HOMOLOGOUS DOMAIN OF HUMAN FKBP25
    1pbk: HOMOLOGOUS DOMAIN OF HUMAN FKBP25
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