FOSL2

Protein-coding gene in the species Homo sapiens
FOSL2
Identifiers
AliasesFOSL2, Fos-Related Antigen, FRA-2, FRA2, FOS like 2, AP-1 transcription factor subunit
External IDsOMIM: 601575 MGI: 102858 HomoloGene: 3845 GeneCards: FOSL2
Gene location (Human)
Chromosome 2 (human)
Chr.Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for FOSL2
Genomic location for FOSL2
Band2p23.2Start28,392,448 bp[1]
End28,417,317 bp[1]
Gene location (Mouse)
Chromosome 5 (mouse)
Chr.Chromosome 5 (mouse)[2]
Chromosome 5 (mouse)
Genomic location for FOSL2
Genomic location for FOSL2
Band5 B1|5 17.33 cMStart32,293,145 bp[2]
End32,315,186 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • gastric mucosa

  • popliteal artery

  • vagina

  • left uterine tube

  • pericardium

  • gallbladder

  • skin of abdomen

  • canal of the cervix

  • sural nerve

  • human penis
Top expressed in
  • mucosa of urinary bladder

  • hair follicle

  • medullary collecting duct

  • conjunctival fornix

  • left colon

  • belly cord

  • ascending aorta

  • epithelium of stomach

  • cumulus cell

  • aortic valve
More reference expression data
BioGPS




More reference expression data
Gene ontology
Molecular function
  • DNA-binding transcription factor activity
  • DNA binding
  • chromatin binding
  • protein binding
  • RNA polymerase II transcription regulatory region sequence-specific DNA binding
  • DNA-binding transcription activator activity, RNA polymerase II-specific
  • DNA-binding transcription factor activity, RNA polymerase II-specific
  • RNA polymerase II cis-regulatory region sequence-specific DNA binding
Cellular component
  • nucleus
  • nucleoplasm
Biological process
  • regulation of transcription by RNA polymerase II
  • positive regulation of transcription, DNA-templated
  • keratinocyte development
  • cell death
  • regulation of transcription, DNA-templated
  • transcription, DNA-templated
  • positive regulation of fibroblast proliferation
  • positive regulation of transcription by RNA polymerase II
  • transcription by RNA polymerase II
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

2355

14284

Ensembl

ENSG00000075426

ENSMUSG00000029135

UniProt

P15408

P47930

RefSeq (mRNA)

NM_005253

NM_008037

RefSeq (protein)

NP_005244

NP_032063

Location (UCSC)Chr 2: 28.39 – 28.42 MbChr 5: 32.29 – 32.32 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Fos-related antigen 2 (FRA2) is a protein that in humans is encoded by the FOSL2 gene.[5]

Function

The Fos gene family consists of 4 members: c-Fos, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation.[5]

See also

  • AP-1 (transcription factor)

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000075426 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029135 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: FOSL2 FOS-like antigen 2".

Further reading

  • Matsui M, Tokuhara M, Konuma Y, Nomura N, Ishizaki R (March 1990). "Isolation of human fos-related genes and their expression during monocyte-macrophage differentiation". Oncogene. 5 (3): 249–55. PMID 2107490.
  • Molven A, Houge G, Berger R (November 1996). "Chromosomal assignment of the human gene encoding the Fos-related antigen-2 (FRA2) to chromosome 2p22-p23". Genomics. 38 (1): 72–5. doi:10.1006/geno.1996.0593. PMID 8954781.
  • Outinen PA, Sood SK, Pfeifer SI, Pamidi S, Podor TJ, Li J, Weitz JI, Austin RC (August 1999). "Homocysteine-induced endoplasmic reticulum stress and growth arrest leads to specific changes in gene expression in human vascular endothelial cells". Blood. 94 (3): 959–67. doi:10.1182/blood.V94.3.959.415k20_959_967. PMID 10419887.
  • Miyamoto NG, Medberry PS, Hesselgesser J, Boehlk S, Nelson PJ, Krensky AM, Perez HD (June 2000). "Interleukin-1beta induction of the chemokine RANTES promoter in the human astrocytoma line CH235 requires both constitutive and inducible transcription factors". Journal of Neuroimmunology. 105 (1): 78–90. doi:10.1016/S0165-5728(00)00195-8. PMID 10713367. S2CID 8547340.
  • Ng DC, Shafaee S, Lee D, Bikle DD (August 2000). "Requirement of an AP-1 site in the calcium response region of the involucrin promoter". The Journal of Biological Chemistry. 275 (31): 24080–8. doi:10.1074/jbc.M002508200. PMID 10816578.
  • Bamberger AM, Milde-Langosch K, Rössing E, Goemann C, Löning T (September 2001). "Expression pattern of the AP-1 family in endometrial cancer: correlations with cell cycle regulators". Journal of Cancer Research and Clinical Oncology. 127 (9): 545–50. doi:10.1007/s004320100255. PMID 11570575. S2CID 7184971.
  • Udalova IA, Kwiatkowski D (November 2001). "Interaction of AP-1 with a cluster of NF-kappa B binding elements in the human TNF promoter region". Biochemical and Biophysical Research Communications. 289 (1): 25–33. doi:10.1006/bbrc.2001.5929. PMID 11708771.
  • Benkoussa M, Brand C, Delmotte MH, Formstecher P, Lefebvre P (July 2002). "Retinoic acid receptors inhibit AP1 activation by regulating extracellular signal-regulated kinase and CBP recruitment to an AP1-responsive promoter". Molecular and Cellular Biology. 22 (13): 4522–34. doi:10.1128/MCB.22.13.4522-4534.2002. PMC 133906. PMID 12052862.
  • Santalucía T, Christmann M, Yacoub MH, Brand NJ (September 2003). "Hypertrophic agonists induce the binding of c-Fos to an AP-1 site in cardiac myocytes: implications for the expression of GLUT1". Cardiovascular Research. 59 (3): 639–48. doi:10.1016/S0008-6363(03)00472-3. PMID 14499865.
  • Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (August 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
  • Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (November 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


  • v
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(1) Basic domains
(1.1) Basic leucine zipper (bZIP)
(1.2) Basic helix-loop-helix (bHLH)
Group A
Group B
Group C
bHLH-PAS
Group D
Group E
Group F
bHLH-COE
(1.3) bHLH-ZIP
(1.4) NF-1
(1.5) RF-X
(1.6) Basic helix-span-helix (bHSH)
(2) Zinc finger DNA-binding domains
(2.1) Nuclear receptor (Cys4)
subfamily 1
subfamily 2
subfamily 3
subfamily 4
subfamily 5
subfamily 6
subfamily 0
(2.2) Other Cys4
(2.3) Cys2His2
(2.4) Cys6
(2.5) Alternating composition
(2.6) WRKY
(3) Helix-turn-helix domains
(3.1) Homeodomain
Antennapedia
ANTP class
protoHOX
Hox-like
metaHOX
NK-like
other
(3.2) Paired box
(3.3) Fork head / winged helix
(3.4) Heat shock factors
(3.5) Tryptophan clusters
(3.6) TEA domain
  • transcriptional enhancer factor
(4) β-Scaffold factors with minor groove contacts
(4.1) Rel homology region
(4.2) STAT
(4.3) p53-like
(4.4) MADS box
(4.6) TATA-binding proteins
(4.7) High-mobility group
(4.9) Grainyhead
(4.10) Cold-shock domain
(4.11) Runt
(0) Other transcription factors
(0.2) HMGI(Y)
(0.3) Pocket domain
(0.5) AP-2/EREBP-related factors
(0.6) Miscellaneous
see also transcription factor/coregulator deficiencies
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