FOXO6

Protein-coding gene in the species Homo sapiens
FOXO6
Identifiers
AliasesFOXO6, forkhead box O6
External IDsOMIM: 611457 MGI: 2676586 HomoloGene: 82395 GeneCards: FOXO6
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for FOXO6
Genomic location for FOXO6
Band1p34.2Start41,361,922 bp[1]
End41,383,590 bp[1]
Gene location (Mouse)
Chromosome 4 (mouse)
Chr.Chromosome 4 (mouse)[2]
Chromosome 4 (mouse)
Genomic location for FOXO6
Genomic location for FOXO6
Band4|4 D2.1Start120,124,276 bp[2]
End120,144,546 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • ganglionic eminence

  • pituitary gland

  • anterior pituitary

  • left lobe of thyroid gland

  • placenta

  • hippocampus proper

  • left uterine tube

  • nucleus accumbens

  • skeletal muscle tissue

  • right lobe of thyroid gland
Top expressed in
  • ganglionic eminence

  • quadriceps femoris muscle

  • nucleus accumbens

  • hippocampus proper

  • skeletal muscle tissue

  • cingulate gyrus

  • Region I of hippocampus proper

  • secondary oocyte

  • lip

  • superior frontal gyrus
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • DNA binding
  • DNA-binding transcription factor activity
  • sequence-specific DNA binding
Cellular component
  • nucleus
Biological process
  • transcription, DNA-templated
  • regulation of transcription, DNA-templated
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

100132074

329934

Ensembl

ENSG00000204060
ENSG00000281518

ENSMUSG00000052135

UniProt

A0A1X9RU27

Q70KY4

RefSeq (mRNA)

NM_001291281

NM_194060

RefSeq (protein)

NP_001278210

NP_918949

Location (UCSC)Chr 1: 41.36 – 41.38 MbChr 4: 120.12 – 120.14 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Forkhead box O6 is a protein that in humans is encoded by the FOXO6 gene.[5]

FoxO6 is expressed in the liver, skeletal muscle, and the hippocampus of the brain.[6] In the liver, FoxO6 normally promotes gluconeogenesis in the fasted state, but insulin blocks Fox06 upon feeding.[6] In a condition of insulin resistance insulin fails to block FoxO6 resulting in continued gluconeogenesis even upon feeding.[6]

References

  1. ^ a b c ENSG00000281518 GRCh38: Ensembl release 89: ENSG00000204060, ENSG00000281518 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000052135 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Forkhead box O6".
  6. ^ a b c Lee S, Dong HH (2017). "FoxO integration of insulin signaling with glucose and lipid metabolism". Journal of Endocrinology. 233 (2): R67–R79. doi:10.1530/JOE-17-0002. PMC 5480241. PMID 28213398.

Further reading

  • Jacobs FM, van der Heide LP, Wijchers PJ, Burbach JP, Hoekman MF, Smidt MP (September 2003). "FoxO6, a novel member of the FoxO class of transcription factors with distinct shuttling dynamics". The Journal of Biological Chemistry. 278 (38): 35959–67. doi:10.1074/jbc.M302804200. PMID 12857750.
  • Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Molecular Medicine. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.
  • Kleindorp R, Flachsbart F, Puca AA, Malovini A, Schreiber S, Nebel A (August 2011). "Candidate gene study of FOXO1, FOXO4, and FOXO6 reveals no association with human longevity in Germans". Aging Cell. 10 (4): 622–8. doi:10.1111/j.1474-9726.2011.00698.x. PMID 21388494.
  • Tzivion G, Dobson M, Ramakrishnan G (November 2011). "FoxO transcription factors; Regulation by AKT and 14-3-3 proteins". Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1813 (11): 1938–45. doi:10.1016/j.bbamcr.2011.06.002. PMID 21708191.
  • Kim DH, Perdomo G, Zhang T, Slusher S, Lee S, Phillips BE, Fan Y, Giannoukakis N, Gramignoli R, Strom S, Ringquist S, Dong HH (November 2011). "FoxO6 integrates insulin signaling with gluconeogenesis in the liver". Diabetes. 60 (11): 2763–74. doi:10.2337/db11-0548. PMC 3198083. PMID 21940782.
  • Kim DH, Zhang T, Lee S, Dong HH (September 2013). "FoxO6 in glucose metabolism (FoxO6)". Journal of Diabetes. 5 (3): 233–40. doi:10.1111/1753-0407.12027. PMC 3657578. PMID 23324123.
  • Qinyu L, Long C, Zhen-dong D, Min-min S, Wei-ze W, Wei-ping Y, Cheng-hong P (July 2013). "FOXO6 promotes gastric cancer cell tumorigenicity via upregulation of C-myc". FEBS Letters. 587 (14): 2105–11. doi:10.1016/j.febslet.2013.05.027. PMID 23714368. S2CID 38064268.
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