FOXQ1

Protein-coding gene in the species Homo sapiens
FOXQ1
Identifiers
AliasesFOXQ1, HFH1, forkhead box Q1
External IDsOMIM: 612788 MGI: 1298228 HomoloGene: 7359 GeneCards: FOXQ1
Gene location (Human)
Chromosome 6 (human)
Chr.Chromosome 6 (human)[1]
Chromosome 6 (human)
Genomic location for FOXQ1
Genomic location for FOXQ1
Band6p25.3Start1,312,098 bp[1]
End1,314,758 bp[1]
Gene location (Mouse)
Chromosome 13 (mouse)
Chr.Chromosome 13 (mouse)[2]
Chromosome 13 (mouse)
Genomic location for FOXQ1
Genomic location for FOXQ1
Band13 A3.2|13 13.46 cMStart31,740,117 bp[2]
End31,744,959 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • parotid gland

  • pylorus

  • pancreatic epithelial cell

  • pancreatic ductal cell

  • endothelial cell

  • palpebral conjunctiva

  • secondary oocyte

  • trachea

  • urethra

  • cardia
Top expressed in
  • conjunctival fornix

  • pyloric antrum

  • epithelium of stomach

  • hair follicle

  • mucous cell of stomach

  • medullary collecting duct

  • submandibular gland

  • cornea

  • duodenum

  • corneal stroma
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • DNA-binding transcription factor activity
  • sequence-specific DNA binding
  • DNA binding
  • RNA polymerase II cis-regulatory region sequence-specific DNA binding
  • DNA-binding transcription repressor activity, RNA polymerase II-specific
  • DNA-binding transcription factor activity, RNA polymerase II-specific
Cellular component
  • nucleus
Biological process
  • hair follicle morphogenesis
  • regulation of transcription, DNA-templated
  • transcription, DNA-templated
  • negative regulation of transcription by RNA polymerase II
  • anatomical structure morphogenesis
  • cell differentiation
  • regulation of transcription by RNA polymerase II
  • negative regulation of neuron apoptotic process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

94234

15220

Ensembl

ENSG00000164379

ENSMUSG00000038415

UniProt

Q9C009

O70220

RefSeq (mRNA)

NM_033260

NM_008239

RefSeq (protein)

NP_150285

NP_032265

Location (UCSC)Chr 6: 1.31 – 1.31 MbChr 13: 31.74 – 31.74 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Forkhead box Q1 is a protein that in humans is encoded by the FOXQ1 gene. [5]

Function

FOXQ1 is a member of the FOX gene family, which is characterized by a conserved 110-amino acid DNA-binding motif called the forkhead or winged helix domain. FOX genes are involved in embryonic development, cell cycle regulation, tissue-specific gene expression, cell signaling, and tumorigenesis (Bieller et al., 2001 [PubMed 11747606]).

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000164379 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000038415 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Forkhead box Q1". Retrieved 2016-03-14.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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