Fursultiamine

Chemical compound
  • None
Legal statusLegal status
  • In general: Over-the-counter (OTC)
Identifiers
  • N-[(4-Amino-2-methylpyrimidin-5-yl)methyl]-N-{(1E)-4-hydroxy-1-methyl-2-[(tetrahydrofuran-2-ylmethyl)disulfanyl]but-1-en-1-yl}formamide
CAS Number
  • 804-30-8
PubChem CID
  • 3002119
DrugBank
  • DB08966 ☒N
ChemSpider
  • 2273321
UNII
  • 05J61265PX
ChEMBL
  • ChEMBL1740659
CompTox Dashboard (EPA)
  • DTXSID0023084 Edit this at Wikidata
ECHA InfoCard100.011.234 Edit this at WikidataChemical and physical dataFormulaC17H26N4O3S2Molar mass398.54 g·mol−13D model (JSmol)
  • Interactive image
  • O=CN(\C(=C(\SSCC1OCCC1)CCO)C)Cc2cnc(nc2N)C

Fursultiamine (INN; chemical name thiamine tetrahydrofurfuryl disulfide or TTFD; brand names Adventan, Alinamin-F, Benlipoid, Bevitol Lipophil, Judolor, Lipothiamine) is a medication and vitamin used to treat thiamine deficiency. Chemically, it is a disulfide derivative of thiamine and is similar in structure to allithiamine.[1]

It was synthesized in Japan in the 1960s from allithiamine for the purpose of developing forms of thiamine with improved lipophilicity for treating vitamin B1 deficiency (i.e., beriberi),[1] It was subsequently commercialized not only in Japan but also in Spain, Austria, Germany, and the United States.[2]

See also

  • Vitamin B1 analogue

References

  1. ^ a b Lonsdale D (September 2004). "Thiamine tetrahydrofurfuryl disulfide: a little known therapeutic agent". Medical Science Monitor. 10 (9): RA199–203. PMID 15328496.
  2. ^ Swiss Pharmaceutical Society (2000). Index Nominum 2000: International Drug Directory (Book with CD-ROM). Boca Raton: Medpharm Scientific Publishers. p. 1932. ISBN 3-88763-075-0.

Further reading

  • Lonsdale D (September 2004). "Thiamine tetrahydrofurfuryl disulfide: a little known therapeutic agent". Medical Science Monitor. 10 (9): RA199–203. PMID 15328496.
  • v
  • t
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Fat
soluble
A
D
E
K
  • Naphthoquinone
  • Phylloquinone (K1)#
  • Menaquinones (K2)
  • Menadione (K3)‡
  • Various (K4)
  • 4-Amino-2-methyl-1-naphthol (K5)‡
  • 2-Methylnaphthalene-1,4-diamine (K6)
  • 4-Amino-3-methyl-1-naphthol (K7)
Water
soluble
B
C
Combinations