Protein-coding gene in the species Homo sapiens
GJB7 |
---|
|
Identifiers |
---|
Aliases | GJB7, CX25, bA136M9.1, connexin25, gap junction protein beta 7 |
---|
External IDs | OMIM: 611921 HomoloGene: 89311 GeneCards: GJB7 |
---|
Gene location (Human) |
---|
| Chr. | Chromosome 6 (human)[1] |
---|
| Band | 6q14.3-q15 | Start | 87,282,980 bp[1] |
---|
End | 87,329,278 bp[1] |
---|
|
RNA expression pattern |
---|
Bgee | Human | Mouse (ortholog) |
---|
Top expressed in | - right uterine tube
- placenta
- pituitary gland
- anterior pituitary
- right lung
- bone marrow
- endometrium
- Achilles tendon
- thymus
- urinary bladder
|
| | More reference expression data |
|
---|
BioGPS | |
---|
|
Gene ontology |
---|
Molecular function | - gap junction channel activity
| Cellular component | - integral component of membrane
- gap junction
- cell junction
- plasma membrane
- connexin complex
- membrane
| Biological process | - cell communication
- transmembrane transport
| Sources:Amigo / QuickGO |
|
Orthologs |
---|
Species | Human | Mouse |
---|
Entrez | | |
---|
Ensembl | | |
---|
UniProt | | |
---|
RefSeq (mRNA) | | |
---|
RefSeq (protein) | | |
---|
Location (UCSC) | Chr 6: 87.28 – 87.33 Mb | n/a |
---|
PubMed search | [2] | n/a |
---|
|
Wikidata |
|
Gap junction beta-7 protein (GJB7), also known as connexin-25 (Cx25), is a protein that in humans is encoded by the GJB7 gene.[3]
Function
Connexins, such as GJB7, are involved in the formation of gap junctions, intercellular conduits that directly connect the cytoplasms of contacting cells. Each gap junction channel is formed by docking of 2 hemichannels, each of which contains 6 connexin subunits.[3][4]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000164411 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b "Entrez Gene: gap junction protein".
- ^ Söhl G, Nielsen PA, Eiberger J, Willecke K (2003). "Expression profiles of the novel human connexin genes hCx30.2, hCx40.1, and hCx62 differ from their putative mouse orthologues". Cell Commun. Adhes. 10 (1): 27–36. doi:10.1080/15419060302063. PMID 12881038. S2CID 225894.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
| This article on a gene on human chromosome 6 is a stub. You can help Wikipedia by expanding it. |