GLRA2

Protein-coding gene in the species Homo sapiens
GLRA2
Identifiers
AliasesGLRA2, GLR, glycine receptor alpha 2, MRXSP
External IDsOMIM: 305990 MGI: 95748 HomoloGene: 31070 GeneCards: GLRA2
Gene location (Human)
X chromosome (human)
Chr.X chromosome (human)[1]
X chromosome (human)
Genomic location for GLRA2
Genomic location for GLRA2
BandXp22.2Start14,529,298 bp[1]
End14,731,812 bp[1]
Gene location (Mouse)
X chromosome (mouse)
Chr.X chromosome (mouse)[2]
X chromosome (mouse)
Genomic location for GLRA2
Genomic location for GLRA2
BandX F5|X 76.75 cMStart163,912,013 bp[2]
End164,110,389 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • ganglionic eminence

  • cerebellar hemisphere

  • hypothalamus

  • prefrontal cortex

  • rectum

  • cingulate gyrus

  • amygdala

  • cerebellar vermis

  • nucleus accumbens

  • Brodmann area 9
Top expressed in
  • ventral tegmental area

  • lateral hypothalamus

  • paraventricular nucleus of hypothalamus

  • nucleus accumbens

  • substantia nigra

  • dorsomedial hypothalamic nucleus

  • fossa

  • facial motor nucleus

  • sexually immature organism

  • condyle
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • metal ion binding
  • glycine binding
  • transmitter-gated ion channel activity
  • chloride channel activity
  • glycine-gated chloride ion channel activity
  • extracellularly glycine-gated chloride channel activity
  • extracellular ligand-gated ion channel activity
  • ion channel activity
  • transmembrane signaling receptor activity
  • transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential
Cellular component
  • synapse
  • integral component of membrane
  • cell projection
  • cell junction
  • integral component of plasma membrane
  • postsynaptic membrane
  • membrane
  • chloride channel complex
  • plasma membrane
  • neuron projection
  • glycinergic synapse
Biological process
  • neuropeptide signaling pathway
  • chloride transmembrane transport
  • chloride transport
  • ion transport
  • cellular response to amino acid stimulus
  • synaptic transmission, glycinergic
  • cellular response to ethanol
  • cellular response to zinc ion
  • excitatory postsynaptic potential
  • ion transmembrane transport
  • signal transduction
  • chemical synaptic transmission
  • regulation of membrane potential
  • response to amino acid
  • nervous system process
  • regulation of postsynaptic membrane potential
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

2742

237213

Ensembl

ENSG00000101958

ENSMUSG00000018589

UniProt

P23416

Q7TNC8

RefSeq (mRNA)

NM_001118885
NM_001118886
NM_001171942
NM_002063

NM_183427
NM_001357099
NM_001357100

RefSeq (protein)

NP_001112357
NP_001112358
NP_001165413
NP_002054

NP_906272
NP_001344028
NP_001344029

Location (UCSC)Chr X: 14.53 – 14.73 MbChr X: 163.91 – 164.11 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Glycine receptor subunit alpha-2 is a protein that in humans is encoded by the GLRA2 gene.[5]


See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000101958 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000018589 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: GLRA2 glycine receptor, alpha 2".

Further reading

  • Grenningloh G, Schmieden V, Schofield PR, et al. (1990). "Alpha subunit variants of the human glycine receptor: primary structures, functional expression and chromosomal localization of the corresponding genes". EMBO J. 9 (3): 771–6. doi:10.1002/j.1460-2075.1990.tb08172.x. PMC 551735. PMID 2155780.
  • Monani U, Burghes AH (1997). "Structure of the human alpha 2 subunit gene of the glycine receptor--use of vectorette and Alu-exon PCR". Genome Res. 6 (12): 1200–6. doi:10.1101/gr.6.12.1200. PMID 8973915.
  • Cummings CJ, Dahle EJ, Zoghbi HY (1998). "Analysis of the genomic structure of the human glycine receptor alpha2 subunit gene and exclusion of this gene as a candidate for Rett syndrome". Am. J. Med. Genet. 78 (2): 176–8. doi:10.1002/(SICI)1096-8628(19980630)78:2<176::AID-AJMG16>3.0.CO;2-K. PMID 9674912.
  • Feng J, Craddock N, Jones IR, et al. (2001). "Systematic screening for mutations in the glycine receptor alpha2 subunit gene (GLRA2) in patients with schizophrenia and other psychiatric diseases". Psychiatr. Genet. 11 (1): 45–8. doi:10.1097/00041444-200103000-00009. PMID 11409700. S2CID 5889298.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Davies DL, Crawford DK, Trudell JR, et al. (2004). "Multiple sites of ethanol action in alpha1 and alpha2 glycine receptors suggested by sensitivity to pressure antagonism". J. Neurochem. 89 (5): 1175–85. doi:10.1111/j.1471-4159.2004.02390.x. PMID 15147510.
  • Miller PS, Harvey RJ, Smart TG (2005). "Differential agonist sensitivity of glycine receptor alpha2 subunit splice variants". Br. J. Pharmacol. 143 (1): 19–26. doi:10.1038/sj.bjp.0705875. PMC 1575261. PMID 15302677.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Miller PS, Da Silva HM, Smart TG (2006). "Molecular basis for zinc potentiation at strychnine-sensitive glycine receptors". J. Biol. Chem. 280 (45): 37877–84. doi:10.1074/jbc.M508303200. PMID 16144831.

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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