GLRA3

Protein-coding gene in the species Homo sapiens
GLRA3
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

5CFB

Identifiers
AliasesGLRA3, glycine receptor alpha 3
External IDsOMIM: 600421 MGI: 95749 HomoloGene: 142 GeneCards: GLRA3
Gene location (Human)
Chromosome 4 (human)
Chr.Chromosome 4 (human)[1]
Chromosome 4 (human)
Genomic location for GLRA3
Genomic location for GLRA3
Band4q34.1Start174,636,920 bp[1]
End174,829,247 bp[1]
Gene location (Mouse)
Chromosome 8 (mouse)
Chr.Chromosome 8 (mouse)[2]
Chromosome 8 (mouse)
Genomic location for GLRA3
Genomic location for GLRA3
Band8 B2|8 29.69 cMStart56,393,495 bp[2]
End56,583,105 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • pancreatic ductal cell

  • prefrontal cortex

  • islet of Langerhans

  • Brodmann area 9

  • cingulate gyrus

  • hypothalamus

  • amygdala

  • lower lobe of lung

  • substantia nigra

  • nucleus accumbens
Top expressed in
  • substantia nigra

  • ventromedial nucleus

  • ventral tegmental area

  • dorsomedial hypothalamic nucleus

  • superior colliculus

  • paraventricular nucleus of hypothalamus

  • lateral hypothalamus

  • utricle

  • piriform cortex

  • arcuate nucleus
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • glycine-gated chloride ion channel activity
  • glycine binding
  • metal ion binding
  • transmitter-gated ion channel activity
  • chloride channel activity
  • extracellular ligand-gated ion channel activity
  • extracellularly glycine-gated chloride channel activity
  • ion channel activity
  • transmembrane signaling receptor activity
Cellular component
  • integral component of membrane
  • perikaryon
  • postsynaptic membrane
  • cell projection
  • membrane
  • plasma membrane
  • synapse
  • integral component of plasma membrane
  • chloride channel complex
  • glycine-gated chloride channel complex
  • cell junction
  • dendrite
  • neuron projection
Biological process
  • response to amino acid
  • chloride transmembrane transport
  • ion transport
  • synaptic transmission, glycinergic
  • chloride transport
  • neuropeptide signaling pathway
  • protein homooligomerization
  • excitatory postsynaptic potential
  • ion transmembrane transport
  • signal transduction
  • chemical synaptic transmission
  • regulation of membrane potential
  • nervous system process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

8001

110304

Ensembl

ENSG00000145451

ENSMUSG00000038257

UniProt

O75311

Q91XP5

RefSeq (mRNA)

NM_001042543
NM_006529

NM_080438
NM_001368774

RefSeq (protein)

NP_001036008
NP_006520

NP_536686
NP_001355703

Location (UCSC)Chr 4: 174.64 – 174.83 MbChr 8: 56.39 – 56.58 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The Glycine receptor subunit alpha-3 is a protein that in humans is encoded by the GLRA3 gene.[5] The protein encoded by this gene is a subunit of the glycine receptor.[5]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000145451 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000038257 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b Nikolic Z, Laube B, Weber RG, Lichter P, Kioschis P, Poustka A, Mulhardt C, Becker CM (Sep 1998). "The human glycine receptor subunit alpha3. Glra3 gene structure, chromosomal localization, and functional characterization of alternative transcripts". J Biol Chem. 273 (31): 19708–14. doi:10.1074/jbc.273.31.19708. PMID 9677400.

Further reading

  • Breitinger HG, Villmann C, Rennert J, et al. (2002). "Hydroxylated residues influence desensitization behaviour of recombinant alpha3 glycine receptor channels". J. Neurochem. 83 (1): 30–6. doi:10.1046/j.1471-4159.2002.01109.x. PMID 12358726. S2CID 15091954.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
  • Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. Bibcode:2000PNAS...97.3491D. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Gratacòs M, Costas J, de Cid R, et al. (2009). "Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment". Am. J. Med. Genet. B Neuropsychiatr. Genet. 150B (6): 808–16. doi:10.1002/ajmg.b.30902. PMID 19086053. S2CID 44524739.

External links

  • GLRA3+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
  • PDBe-KB provides an overview of all the structure information available in the PDB for Human Glycine receptor subunit alpha-3 (GLRA3)
  • v
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Cys-loop receptors
5-HT/serotonin
GABA
  • GABAA
    • α1
    • α2
    • α3
    • α4
    • α5
    • α6
    • β1
    • β2
    • β3
    • γ1
    • γ2
    • γ3
    • δ
    • ε
    • π
    • θ
  • GABAA-ρ
    • ρ1
    • ρ2
    • ρ3
Glycine
  • α1
  • α2
  • α3
  • α4
  • β
Nicotinic acetylcholine
  • pentamers: (α3)2(β4)3
  • (α4)2(β2)3
  • (α7)5
  • (α1)2(β4)3 - Ganglion type
  • (α1)2β1δε - Muscle type
Zinc
Ionotropic glutamates
Ligand-gated only
Voltage- and ligand-gated
‘Orphan’
  • GluD
    • δ1
    • δ2
ATP-gated channels
Purinergic receptors


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