GNA11

Protein-coding gene in the species Homo sapiens
GNA11
Identifiers
AliasesGNA11, FBH, FBH2, FHH2, GNA-11, HHC2, HYPOC2, G protein subunit alpha 11, HG1K
External IDsOMIM: 139313 MGI: 95766 HomoloGene: 20474 GeneCards: GNA11
Gene location (Human)
Chromosome 19 (human)
Chr.Chromosome 19 (human)[1]
Chromosome 19 (human)
Genomic location for GNA11
Genomic location for GNA11
Band19p13.3Start3,094,362 bp[1]
End3,123,999 bp[1]
Gene location (Mouse)
Chromosome 10 (mouse)
Chr.Chromosome 10 (mouse)[2]
Chromosome 10 (mouse)
Genomic location for GNA11
Genomic location for GNA11
Band10 C1|10 39.72 cMStart81,364,558 bp[2]
End81,381,024 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • jejunal mucosa

  • pancreatic ductal cell

  • duodenum

  • secondary oocyte

  • cerebellar vermis

  • parotid gland

  • stromal cell of endometrium

  • nipple

  • rectum

  • saphenous vein
Top expressed in
  • crypt of lieberkuhn of small intestine

  • duodenum

  • jejunum

  • ileum

  • intestinal villus

  • left colon

  • Paneth cell

  • calvaria

  • condyle

  • ankle
More reference expression data
BioGPS




More reference expression data
Gene ontology
Molecular function
  • nucleotide binding
  • type 2A serotonin receptor binding
  • GTP binding
  • metal ion binding
  • guanyl nucleotide binding
  • G protein-coupled receptor binding
  • GTPase activity
  • signal transducer activity
  • G-protein beta/gamma-subunit complex binding
  • protein binding
Cellular component
  • cytoplasm
  • membrane
  • plasma membrane
  • photoreceptor outer segment
  • lysosomal membrane
  • extracellular exosome
  • heterotrimeric G-protein complex
Biological process
  • G protein-coupled acetylcholine receptor signaling pathway
  • skeletal system development
  • regulation of melanocyte differentiation
  • entrainment of circadian clock
  • platelet activation
  • heart development
  • cellular response to pH
  • phospholipase C-activating dopamine receptor signaling pathway
  • phototransduction, visible light
  • developmental pigmentation
  • action potential
  • signal transduction
  • adenylate cyclase-modulating G protein-coupled receptor signaling pathway
  • G protein-coupled receptor signaling pathway
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

2767

14672

Ensembl

ENSG00000088256

ENSMUSG00000034781

UniProt

P29992

P21278

RefSeq (mRNA)

NM_002067

NM_010301

RefSeq (protein)

NP_002058

NP_034431

Location (UCSC)Chr 19: 3.09 – 3.12 MbChr 10: 81.36 – 81.38 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Guanine nucleotide-binding protein subunit alpha-11 is a protein that in humans is encoded by the GNA11 gene.[5][6] Together with GNAQ (its paralogue), it functions as a Gq alpha subunit.[7]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000088256 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000034781 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Wilkie TM, Gilbert DJ, Olsen AS, Chen XN, Amatruda TT, Korenberg JR, Trask BJ, de Jong P, Reed RR, Simon MI, et al. (Jun 1993). "Evolution of the mammalian G protein alpha subunit multigene family". Nat Genet. 1 (2): 85–91. doi:10.1038/ng0592-85. PMID 1302014. S2CID 31888533.
  6. ^ "Entrez Gene: GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class)".
  7. ^ 139313 GUANINE NUCLEOTIDE-BINDING PROTEIN, ALPHA-11; GNA11 at OMIM. Retrieved January 1, 2015.

Further reading

  • Raymond JR, Mukhin YV, Gelasco A, et al. (2002). "Multiplicity of mechanisms of serotonin receptor signal transduction". Pharmacol. Ther. 92 (2–3): 179–212. doi:10.1016/S0163-7258(01)00169-3. PMID 11916537.
  • Jiang M, Pandey S, Tran VT, Fong HK (1991). "Guanine nucleotide-binding regulatory proteins in retinal pigment epithelial cells". Proc. Natl. Acad. Sci. U.S.A. 88 (9): 3907–11. Bibcode:1991PNAS...88.3907J. doi:10.1073/pnas.88.9.3907. PMC 51562. PMID 1902575.
  • Thomas CP, Dunn MJ, Mattera R (1996). "Ca2+ signalling in K562 human erythroleukaemia cells: effect of dimethyl sulphoxide and role of G-proteins in thrombin- and thromboxane A2-activated pathways". Biochem. J. 312 (1): 151–8. doi:10.1042/bj3120151. PMC 1136238. PMID 7492305.
  • Offermanns S, Simon MI (1995). "G alpha 15 and G alpha 16 couple a wide variety of receptors to phospholipase C". J. Biol. Chem. 270 (25): 15175–80. doi:10.1074/jbc.270.25.15175. PMID 7797501.
  • Stanners J, Kabouridis PS, McGuire KL, Tsoukas CD (1996). "Interaction between G proteins and tyrosine kinases upon T cell receptor.CD3-mediated signaling". J. Biol. Chem. 270 (51): 30635–42. doi:10.1074/jbc.270.51.30635. PMID 8530500.
  • Laugwitz KL, Allgeier A, Offermanns S, et al. (1996). "The human thyrotropin receptor: a heptahelical receptor capable of stimulating members of all four G protein families". Proc. Natl. Acad. Sci. U.S.A. 93 (1): 116–20. Bibcode:1996PNAS...93..116L. doi:10.1073/pnas.93.1.116. PMC 40189. PMID 8552586.
  • Launay JM, Birraux G, Bondoux D, et al. (1996). "Ras involvement in signal transduction by the serotonin 5-HT2B receptor". J. Biol. Chem. 271 (6): 3141–7. doi:10.1074/jbc.271.6.3141. PMID 8621713.
  • Johnson GJ, Leis LA, Dunlop PC (1996). "Specificity of G alpha q and G alpha 11 gene expression in platelets and erythrocytes. Expressions of cellular differentiation and species differences". Biochem. J. 318 (3): 1023–31. doi:10.1042/bj3181023. PMC 1217719. PMID 8836152.
  • Kinsella BT, O'Mahony DJ, Fitzgerald GA (1997). "The human thromboxane A2 receptor alpha isoform (TP alpha) functionally couples to the G proteins Gq and G11 in vivo and is activated by the isoprostane 8-epi prostaglandin F2 alpha". J. Pharmacol. Exp. Ther. 281 (2): 957–64. PMID 9152406.
  • Wise A, Parenti M, Milligan G (1997). "Interaction of the G-protein G11alpha with receptors and phosphoinositidase C: the contribution of G-protein palmitoylation and membrane association". FEBS Lett. 407 (3): 257–60. doi:10.1016/S0014-5793(97)00300-1. PMID 9175863. S2CID 85622146.
  • Carrasco MP, Asbóth G, Phaneuf S, López Bernal A (1998). "Activation of the prostaglandin FP receptor in human granulosa cells". J. Reprod. Fertil. 111 (2): 309–17. doi:10.1530/jrf.0.1110309. PMID 9462300.
  • Qian A, Wang W, Sanborn BM (1998). "Evidence for the involvement of several intracellular domains in the coupling of oxytocin receptor to G alpha(q/11)". Cell. Signal. 10 (2): 101–5. doi:10.1016/S0898-6568(97)00097-1. PMID 9481484.
  • Dulin NO, Sorokin A, Reed E, et al. (1999). "RGS3 inhibits G protein-mediated signaling via translocation to the membrane and binding to Galpha11". Mol. Cell. Biol. 19 (1): 714–23. doi:10.1128/MCB.19.1.714. PMC 83928. PMID 9858594.
  • Hayes JS, Lawler OA, Walsh MT, Kinsella BT (1999). "The prostacyclin receptor is isoprenylated. Isoprenylation is required for efficient receptor-effector coupling". J. Biol. Chem. 274 (34): 23707–18. doi:10.1074/jbc.274.34.23707. PMID 10446129.
  • Brydon L, Roka F, Petit L, et al. (2000). "Dual signaling of human Mel1a melatonin receptors via G(i2), G(i3), and G(q/11) proteins". Mol. Endocrinol. 13 (12): 2025–38. doi:10.1210/mend.13.12.0390. PMID 10598579.
  • Corbetta S, Mantovani G, Lania A, et al. (2000). "Calcium-sensing receptor expression and signalling in human parathyroid adenomas and primary hyperplasia". Clin. Endocrinol. 52 (3): 339–48. doi:10.1046/j.1365-2265.2000.00933.x. PMID 10718832. S2CID 39998840.
  • Shraga-Levine Z, Sokolovsky M (2000). "Functional coupling of G proteins to endothelin receptors is ligand and receptor subtype specific". Cell. Mol. Neurobiol. 20 (3): 305–17. doi:10.1023/A:1007010125316. PMID 10789830. S2CID 21841332.
  • AbdAlla S, Lother H, Abdel-tawab AM, Quitterer U (2001). "The angiotensin II AT2 receptor is an AT1 receptor antagonist". J. Biol. Chem. 276 (43): 39721–6. doi:10.1074/jbc.M105253200. PMID 11507095.


  • v
  • t
  • e
MAP
  • see MAP kinase pathway
CalciumG protein
Heterotrimeric
cAMP:
cGMP:
Monomeric
CyclinLipidOther protein kinase
Serine/threonine:
Tyrosine:
Serine/threonine/tyrosine
Arginine
Other protein phosphatase
Serine/threonine:
Tyrosine:
both:
Apoptosis
  • see apoptosis signaling pathway
GTP-binding protein regulators
  • see GTP-binding protein regulators
Other
see also deficiencies of intracellular signaling peptides and proteins
  • v
  • t
  • e
3.6.1
3.6.2
3.6.3-4: ATPase
3.6.3
Cu++ (3.6.3.4)
Ca+ (3.6.3.8)
Na+/K+ (3.6.3.9)
H+/K+ (3.6.3.10)
  • ATP4A
Other P-type ATPase
3.6.4
3.6.5: GTPase
3.6.5.1: Heterotrimeric G protein
3.6.5.2: Small GTPase > Ras superfamily
3.6.5.3: Protein-synthesizing GTPase
3.6.5.5-6: Polymerization motors


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