GNA14

Protein-coding gene in the species Homo sapiens
GNA14
Identifiers
AliasesGNA14, G protein subunit alpha 14, HG1I
External IDsOMIM: 604397 MGI: 95769 HomoloGene: 68386 GeneCards: GNA14
Gene location (Human)
Chromosome 9 (human)
Chr.Chromosome 9 (human)[1]
Chromosome 9 (human)
Genomic location for GNA14
Genomic location for GNA14
Band9q21.2Start77,423,079 bp[1]
End77,648,322 bp[1]
Gene location (Mouse)
Chromosome 19 (mouse)
Chr.Chromosome 19 (mouse)[2]
Chromosome 19 (mouse)
Genomic location for GNA14
Genomic location for GNA14
Band19 A|19 11.29 cMStart16,413,126 bp[2]
End16,588,184 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • secondary oocyte

  • bronchial epithelial cell

  • smooth muscle tissue

  • left lobe of thyroid gland

  • right lobe of thyroid gland

  • myometrium

  • upper lobe of left lung

  • right lung

  • rectum

  • sperm
Top expressed in
  • secondary oocyte

  • facial motor nucleus

  • left colon

  • stria vascularis

  • adrenal gland

  • rectum

  • primitive streak

  • Hindgut

  • anterior horn of spinal cord

  • cumulus cell
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • guanyl nucleotide binding
  • nucleotide binding
  • GTP binding
  • protein binding
  • metal ion binding
  • G protein-coupled receptor binding
  • GTPase activity
  • signal transducer activity
  • G-protein beta/gamma-subunit complex binding
Cellular component
  • plasma membrane
  • extracellular exosome
  • heterotrimeric G-protein complex
Biological process
  • platelet activation
  • phospholipase C-activating dopamine receptor signaling pathway
  • signal transduction
  • adenylate cyclase-modulating G protein-coupled receptor signaling pathway
  • G protein-coupled receptor signaling pathway
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

9630

14675

Ensembl

ENSG00000156049

ENSMUSG00000024697

UniProt

O95837

P30677

RefSeq (mRNA)

NM_004297

NM_008137

RefSeq (protein)

NP_004288

NP_032163

Location (UCSC)Chr 9: 77.42 – 77.65 MbChr 19: 16.41 – 16.59 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Guanine nucleotide-binding protein subunit alpha-14 is a protein that in humans is encoded by the GNA14 gene.[5][6][7] G14α is a member of the Gq alpha subunit family, and functions as a constituent of a heterotrimeric G protein in cell signal transduction.

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000156049 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024697 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Wilkie TM, Gilbert DJ, Olsen AS, Chen XN, Amatruda TT, Korenberg JR, Trask BJ, de Jong P, Reed RR, Simon MI, et al. (Jun 1993). "Evolution of the mammalian G protein alpha subunit multigene family". Nat Genet. 1 (2): 85–91. doi:10.1038/ng0592-85. PMID 1302014. S2CID 31888533.
  6. ^ "Entrez Gene: GNA14 G protein subunit alpha 14 [ Homo sapiens (human) ]". Retrieved 2019-07-25.
  7. ^ GUANINE NUCLEOTIDE-BINDING PROTEIN, ALPHA-14; GNA14 at OMIM. Retrieved JULY 25, 2019.