GNG3

Protein-coding gene in the species Homo sapiens
GNG3
Identifiers
AliasesGNG3, G protein subunit gamma 3, HG3D
External IDsOMIM: 608941 MGI: 102704 HomoloGene: 22575 GeneCards: GNG3
Gene location (Human)
Chromosome 11 (human)
Chr.Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for GNG3
Genomic location for GNG3
Band11q12.3Start62,707,676 bp[1]
End62,709,201 bp[1]
Gene location (Mouse)
Chromosome 19 (mouse)
Chr.Chromosome 19 (mouse)[2]
Chromosome 19 (mouse)
Genomic location for GNG3
Genomic location for GNG3
Band19 A|19 5.76 cMStart8,814,297 bp[2]
End8,816,558 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • dorsolateral prefrontal cortex

  • prefrontal cortex

  • cingulate gyrus

  • Brodmann area 9

  • spinal ganglia

  • amygdala

  • ganglionic eminence

  • nucleus accumbens

  • Brodmann area 46

  • caudate nucleus
Top expressed in
  • entorhinal cortex

  • medial dorsal nucleus

  • inferior colliculus

  • subiculum

  • superior colliculus

  • primary motor cortex

  • paraventricular nucleus of hypothalamus

  • medulla oblongata

  • supraoptic nucleus

  • prefrontal cortex
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • G protein-coupled receptor binding
  • signal transducer activity
  • type 1 angiotensin receptor binding
  • protein binding
  • GTPase activity
  • G-protein beta-subunit binding
Cellular component
  • cell body
  • plasma membrane
  • dendrite
  • membrane
  • heterotrimeric G-protein complex
  • postsynaptic density
  • G-protein beta/gamma-subunit complex
Biological process
  • positive regulation of cytosolic calcium ion concentration
  • G protein-coupled receptor signaling pathway
  • signal transduction
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

2785

14704

Ensembl

ENSG00000162188

ENSMUSG00000071658

UniProt

P63215

P63216

RefSeq (mRNA)

NM_012202

NM_010316

RefSeq (protein)

NP_036334

NP_034446

Location (UCSC)Chr 11: 62.71 – 62.71 MbChr 19: 8.81 – 8.82 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 is a protein that in humans is encoded by the GNG3 gene.[5][6]

G proteins are heterotrimers of alpha, beta, and gamma subunits. Gamma subunits, such as GNG3, contribute to the specificity of the hundreds of receptor signaling pathways involving G proteins (Schwindinger et al., 2004).[supplied by OMIM][6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000162188 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000071658 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Downes GB, Gautam N (Mar 2000). "The G protein subunit gene families". Genomics. 62 (3): 544–52. doi:10.1006/geno.1999.5992. PMID 10644457.
  6. ^ a b "Entrez Gene: GNG3 guanine nucleotide binding protein (G protein), gamma 3".

Further reading

  • Wedegaertner PB, Wilson PT, Bourne HR (1995). "Lipid modifications of trimeric G proteins". J. Biol. Chem. 270 (2): 503–6. doi:10.1074/jbc.270.2.503. PMID 7822269.
  • Garcia-Higuera I, Thomas TC, Yi F, Neer EJ (1996). "Intersubunit surfaces in G protein alpha beta gamma heterotrimers. Analysis by cross-linking and mutagenesis of beta gamma". J. Biol. Chem. 271 (1): 528–35. doi:10.1074/jbc.271.1.528. PMID 8550614.
  • Yan K, Kalyanaraman V, Gautam N (1996). "Differential ability to form the G protein betagamma complex among members of the beta and gamma subunit families". J. Biol. Chem. 271 (12): 7141–6. doi:10.1074/jbc.271.12.7141. PMID 8636150.
  • Morishita R, Saga S, Kawamura N, et al. (1997). "Differential localization of the gamma 3 and gamma 12 subunits of G proteins in the mammalian brain". J. Neurochem. 68 (2): 820–7. doi:10.1046/j.1471-4159.1997.68020820.x. PMID 9003074. S2CID 83968908.
  • Bell B, Xing H, Yan K, et al. (1999). "KSR-1 binds to G-protein betagamma subunits and inhibits beta gamma-induced mitogen-activated protein kinase activation". J. Biol. Chem. 274 (12): 7982–6. doi:10.1074/jbc.274.12.7982. PMID 10075696.
  • Hurowitz EH, Melnyk JM, Chen YJ, et al. (2000). "Genomic characterization of the human heterotrimeric G protein alpha, beta, and gamma subunit genes". DNA Res. 7 (2): 111–20. doi:10.1093/dnares/7.2.111. PMID 10819326.
  • Evanko DS, Thiyagarajan MM, Siderovski DP, Wedegaertner PB (2001). "Gbeta gamma isoforms selectively rescue plasma membrane localization and palmitoylation of mutant Galphas and Galphaq". J. Biol. Chem. 276 (26): 23945–53. doi:10.1074/jbc.M101154200. PMID 11294873.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Cuello F, Schulze RA, Heemeyer F, et al. (2003). "Activation of heterotrimeric G proteins by a high energy phosphate transfer via nucleoside diphosphate kinase (NDPK) B and Gbeta subunits. Complex formation of NDPK B with Gbeta gamma dimers and phosphorylation of His-266 IN Gbeta". J. Biol. Chem. 278 (9): 7220–6. doi:10.1074/jbc.M210304200. PMID 12486123.
  • Kato C, Mizutani T, Tamaki H, et al. (2004). "Characterization of heterotrimeric G protein complexes in rice plasma membrane". Plant J. 38 (2): 320–31. doi:10.1111/j.1365-313X.2004.02046.x. PMID 15078334.
  • Schwindinger WF, Giger KE, Betz KS, et al. (2004). "Mice with Deficiency of G Protein γ3 Are Lean and Have Seizures". Mol. Cell. Biol. 24 (17): 7758–68. doi:10.1128/MCB.24.17.7758-7768.2004. PMC 506985. PMID 15314181.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.


  • v
  • t
  • e
MAP
  • see MAP kinase pathway
CalciumG protein
Heterotrimeric
cAMP:
cGMP:
Monomeric
CyclinLipidOther protein kinase
Serine/threonine:
Tyrosine:
Serine/threonine/tyrosine
Arginine
Other protein phosphatase
Serine/threonine:
Tyrosine:
both:
Apoptosis
  • see apoptosis signaling pathway
GTP-binding protein regulators
  • see GTP-binding protein regulators
Other
see also deficiencies of intracellular signaling peptides and proteins


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