GNG4

Protein-coding gene in the species Homo sapiens
GNG4
Identifiers
AliasesGNG4, G protein subunit gamma 4, HG3C
External IDsOMIM: 604388 MGI: 102703 HomoloGene: 3299 GeneCards: GNG4
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for GNG4
Genomic location for GNG4
Band1q42.3Start235,547,685 bp[1]
End235,650,754 bp[1]
Gene location (Mouse)
Chromosome 13 (mouse)
Chr.Chromosome 13 (mouse)[2]
Chromosome 13 (mouse)
Genomic location for GNG4
Genomic location for GNG4
Band13 A1|13 5.29 cMStart13,958,644 bp[2]
End14,002,481 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • ganglionic eminence

  • islet of Langerhans

  • hypothalamus

  • amygdala

  • pituitary gland

  • caudate nucleus

  • nucleus accumbens

  • prefrontal cortex

  • superior frontal gyrus

  • anterior pituitary
Top expressed in
  • facial motor nucleus

  • substantia nigra

  • olfactory bulb

  • islet of Langerhans

  • supraoptic nucleus

  • paraventricular nucleus of hypothalamus

  • molar

  • condyle

  • fossa

  • ventral tegmental area
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • protein binding
  • signal transducer activity
  • GTPase activity
  • G-protein beta-subunit binding
Cellular component
  • plasma membrane
  • extracellular exosome
  • membrane
  • heterotrimeric G-protein complex
  • G-protein beta/gamma-subunit complex
Biological process
  • G protein-coupled receptor signaling pathway
  • cellular response to glucagon stimulus
  • negative regulation of cell growth
  • regulation of G protein-coupled receptor signaling pathway
  • signal transduction
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

2786

14706

Ensembl

ENSG00000168243
ENSG00000282972

ENSMUSG00000021303

UniProt

P50150

P50153

RefSeq (mRNA)

NM_001098721
NM_001098722
NM_004485

NM_010317
NM_001302997

RefSeq (protein)

NP_001092191
NP_001092192
NP_004476

NP_001289926
NP_034447

Location (UCSC)Chr 1: 235.55 – 235.65 MbChr 13: 13.96 – 14 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 is a protein that in humans is encoded by the GNG4 gene.[5][6]

Interactions

GNG4 has been shown to sometimes interact with GNB1.[5]{[7]

References

  1. ^ a b c ENSG00000282972 GRCh38: Ensembl release 89: ENSG00000168243, ENSG00000282972 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021303 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b Ray K, Kunsch C, Bonner LM, Robishaw JD (Oct 1995). "Isolation of cDNA clones encoding eight different human G protein gamma subunits, including three novel forms designated the gamma 4, gamma 10, and gamma 11 subunits". J. Biol. Chem. 270 (37): 21765–71. doi:10.1074/jbc.270.37.21765. PMID 7665596.
  6. ^ "Entrez Gene: GNG4 guanine nucleotide binding protein (G protein), gamma 4".
  7. ^ Yan K, Kalyanaraman V, Gautam N (Mar 1996). "Differential ability to form the G protein betagamma complex among members of the beta and gamma subunit families". J. Biol. Chem. 271 (12): 7141–6. doi:10.1074/jbc.271.12.7141. PMID 8636150.

Further reading

  • Downes GB, Gautam N (1999). "The G protein subunit gene families". Genomics. 62 (3): 544–52. doi:10.1006/geno.1999.5992. PMID 10644457.
  • Pumiglia KM, LeVine H, Haske T, Habib T, Jove R, Decker SJ (1995). "A direct interaction between G-protein beta gamma subunits and the Raf-1 protein kinase". J. Biol. Chem. 270 (24): 14251–4. doi:10.1074/jbc.270.24.14251. PMID 7782277.
  • Yan K, Kalyanaraman V, Gautam N (1996). "Differential ability to form the G protein betagamma complex among members of the beta and gamma subunit families". J. Biol. Chem. 271 (12): 7141–6. doi:10.1074/jbc.271.12.7141. PMID 8636150.
  • Cuello F, Schulze RA, Heemeyer F, Meyer HE, Lutz S, Jakobs KH, Niroomand F, Wieland T (2003). "Activation of heterotrimeric G proteins by a high energy phosphate transfer via nucleoside diphosphate kinase (NDPK) B and Gbeta subunits. Complex formation of NDPK B with Gbeta gamma dimers and phosphorylation of His-266 IN Gbeta". J. Biol. Chem. 278 (9): 7220–6. doi:10.1074/jbc.M210304200. PMID 12486123.
  • Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
  • v
  • t
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  • e
MAP
  • see MAP kinase pathway
Calcium
G protein
Heterotrimeric
cAMP:
cGMP:
Monomeric
Cyclin
Lipid
Other protein kinase
Serine/threonine:
Tyrosine:
Serine/threonine/tyrosine
Arginine
Other protein phosphatase
Serine/threonine:
Tyrosine:
both:
Apoptosis
  • see apoptosis signaling pathway
GTP-binding protein regulators
  • see GTP-binding protein regulators
Other
see also deficiencies of intracellular signaling peptides and proteins