GNG7

Protein-coding gene in the species Homo sapiens
GNG7
Identifiers
AliasesGNG7, G protein subunit gamma 7, HG3B
External IDsOMIM: 604430 MGI: 95787 HomoloGene: 31293 GeneCards: GNG7
Gene location (Human)
Chromosome 19 (human)
Chr.Chromosome 19 (human)[1]
Chromosome 19 (human)
Genomic location for GNG7
Genomic location for GNG7
Band19p13.3Start2,511,219 bp[1]
End2,702,694 bp[1]
Gene location (Mouse)
Chromosome 10 (mouse)
Chr.Chromosome 10 (mouse)[2]
Chromosome 10 (mouse)
Genomic location for GNG7
Genomic location for GNG7
Band10 C1|10 39.72 cMStart80,784,458 bp[2]
End80,850,779 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • nucleus accumbens

  • caudate nucleus

  • putamen

  • inferior ganglion of vagus nerve

  • external globus pallidus

  • ventral tegmental area

  • subthalamic nucleus

  • superior vestibular nucleus

  • amygdala

  • parietal lobe
Top expressed in
  • olfactory tubercle

  • nucleus accumbens

  • globus pallidus

  • superior frontal gyrus

  • subiculum

  • hippocampus proper

  • temporal lobe

  • amygdala

  • piriform cortex

  • Region I of hippocampus proper
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • signal transducer activity
  • GTPase activity
  • G-protein beta-subunit binding
Cellular component
  • heterotrimeric G-protein complex
  • plasma membrane
  • extracellular exosome
  • membrane
  • G-protein beta/gamma-subunit complex
Biological process
  • G protein-coupled receptor signaling pathway
  • cellular response to glucagon stimulus
  • regulation of G protein-coupled receptor signaling pathway
  • signal transduction
  • behavioral fear response
  • receptor guanylyl cyclase signaling pathway
  • locomotory behavior
  • regulation of adenylate cyclase activity
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

2788

14708

Ensembl

ENSG00000176533

ENSMUSG00000048240

UniProt

O60262

Q61016

RefSeq (mRNA)

NM_052847

NM_001038655
NM_010319

RefSeq (protein)

NP_443079

NP_001033744
NP_034449
NP_001393192
NP_001393193

Location (UCSC)Chr 19: 2.51 – 2.7 MbChr 10: 80.78 – 80.85 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 is a protein that in humans is encoded by the GNG7 gene.[5][6]

Interactions

GNG7 has been shown to interact with GNB5.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000176533 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000048240 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Shibata K, Mori M, Tanaka S, Kitano S, Akiyoshi T (Jun 1998). "Identification and cloning of human G-protein gamma 7, down-regulated in pancreatic cancer". Biochem. Biophys. Res. Commun. 246 (1): 205–9. doi:10.1006/bbrc.1998.8581. PMID 9600093.
  6. ^ "Entrez Gene: GNG7 guanine nucleotide binding protein (G protein), gamma 7".
  7. ^ Yan K, Kalyanaraman V, Gautam N (Mar 1996). "Differential ability to form the G protein betagamma complex among members of the beta and gamma subunit families". J. Biol. Chem. 271 (12): 7141–6. doi:10.1074/jbc.271.12.7141. PMID 8636150.

Further reading

  • Ueda N, Iñiguez-Lluhi JA, Lee E, Smrcka AV, Robishaw JD, Gilman AG (1994). "G protein beta gamma subunits. Simplified purification and properties of novel isoforms". J. Biol. Chem. 269 (6): 4388–95. doi:10.1016/S0021-9258(17)41792-3. PMID 8308009.
  • Yan K, Kalyanaraman V, Gautam N (1996). "Differential ability to form the G protein betagamma complex among members of the beta and gamma subunit families". J. Biol. Chem. 271 (12): 7141–6. doi:10.1074/jbc.271.12.7141. PMID 8636150.
  • Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
  • v
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  • t
  • e
MAP
  • see MAP kinase pathway
Calcium
G protein
Heterotrimeric
cAMP:
cGMP:
Monomeric
Cyclin
Lipid
Other protein kinase
Serine/threonine:
Tyrosine:
Serine/threonine/tyrosine
Arginine
Other protein phosphatase
Serine/threonine:
Tyrosine:
both:
Apoptosis
  • see apoptosis signaling pathway
GTP-binding protein regulators
  • see GTP-binding protein regulators
Other
see also deficiencies of intracellular signaling peptides and proteins