GNGT1

Protein-coding gene in the species Homo sapiens
GNGT1
Identifiers
AliasesGNGT1, GNG1, G protein subunit gamma transducin 1, HG3G1
External IDsOMIM: 189970 MGI: 109165 HomoloGene: 7738 GeneCards: GNGT1
Gene location (Human)
Chromosome 7 (human)
Chr.Chromosome 7 (human)[1]
Chromosome 7 (human)
Genomic location for GNGT1
Genomic location for GNGT1
Band7q21.3Start93,591,573 bp[1]
End93,911,265 bp[1]
Gene location (Mouse)
Chromosome 6 (mouse)
Chr.Chromosome 6 (mouse)[2]
Chromosome 6 (mouse)
Genomic location for GNGT1
Genomic location for GNGT1
Band6|6 A1Start3,993,792 bp[2]
End3,997,436 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • retinal pigment epithelium

  • placenta

  • amniotic fluid

  • monocyte

  • thymus

  • pancreatic ductal cell

  • renal cortex

  • ovary

  • kidney

  • urinary bladder
Top expressed in
  • retinal pigment epithelium

  • pineal gland

  • ciliary body

  • iris

  • internal carotid artery

  • external carotid artery

  • extraocular muscle

  • cornea

  • mucous cell of stomach

  • conjunctival fornix
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • protein binding
  • signal transducer activity
  • GTPase activity
  • G-protein beta-subunit binding
Cellular component
  • photoreceptor inner segment
  • membrane
  • photoreceptor outer segment
  • photoreceptor disc membrane
  • heterotrimeric G-protein complex
  • plasma membrane
  • G-protein beta/gamma-subunit complex
Biological process
  • phototransduction
  • protein localization
  • cardiac muscle cell apoptotic process
  • cellular response to hypoxia
  • rhodopsin mediated signaling pathway
  • eye photoreceptor cell development
  • signal transduction
  • G protein-coupled receptor signaling pathway
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

2792

14699

Ensembl

ENSG00000127928

ENSMUSG00000029663

UniProt

P63211

Q61012

RefSeq (mRNA)

NM_021955
NM_001329426

NM_010314

RefSeq (protein)

NP_001316355
NP_068774

NP_034444

Location (UCSC)Chr 7: 93.59 – 93.91 MbChr 6: 3.99 – 4 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Guanine nucleotide-binding protein G(T) subunit gamma-T1 is a protein that in humans is encoded by the GNGT1 gene.[5][6] Either GNGT1 or GNGT2 is the gamma subunit (Gγ) of the Gβγ part of transducin (written G(T) or Gt), a heterotrimeric G-protein naturally expressed in vertebrate retina rod and cone cells. GNGT1 only occurs in rod cells, and GNGT2 only occurs in cone cells, with a different alpha (Gα) subunit.[7][8]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000127928 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029663 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Scherer SW, Feinstein DS, Oliveira L, Tsui LC, Pittler SJ (Sep 1996). "Gene structure and chromosome localization to 7q21.3 of the human rod photoreceptor transducin gamma-subunit gene (GNGT1)". Genomics. 35 (1): 241–3. doi:10.1006/geno.1996.0346. PMID 8661128.
  6. ^ "Entrez Gene: GNGT1 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1".
  7. ^ Lagman D, Sundström G, Ocampo Daza D, Abalo XM, Larhammar D (2012). "Expansion of transducin subunit gene families in early vertebrate tetraploidizations". Genomics. 100 (4): 203–211. doi:10.1016/j.ygeno.2012.07.005. PMID 22814267.
  8. ^ Lerea CL, Somers DE, Hurley JB, Klock IB, Bunt-Milam AH (October 1986). "Identification of specific transducin alpha subunits in retinal rod and cone photoreceptors". Science. 234 (4772): 77–80. Bibcode:1986Sci...234...77L. doi:10.1126/science.3529395. PMID 3529395.

Further reading

  • Simonds WF, Butrynski JE, Gautam N, et al. (1991). "G-protein beta gamma dimers. Membrane targeting requires subunit coexpression and intact gamma C-A-A-X domain". J. Biol. Chem. 266 (9): 5363–6. doi:10.1016/S0021-9258(19)67601-5. PMID 1706334.
  • Ray K, Kunsch C, Bonner LM, Robishaw JD (1995). "Isolation of cDNA clones encoding eight different human G protein gamma subunits, including three novel forms designated the gamma 4, gamma 10, and gamma 11 subunits". J. Biol. Chem. 270 (37): 21765–71. doi:10.1074/jbc.270.37.21765. PMID 7665596.
  • Tao L, Pandey S, Simon MI, Fong HK (1993). "Structure of the bovine transducin gamma subunit gene and analysis of promoter function in transgenic mice". Exp. Eye Res. 56 (4): 497–507. doi:10.1006/exer.1993.1063. PMID 8500562.
  • Yan K, Kalyanaraman V, Gautam N (1996). "Differential ability to form the G protein betagamma complex among members of the beta and gamma subunit families". J. Biol. Chem. 271 (12): 7141–6. doi:10.1074/jbc.271.12.7141. PMID 8636150.
  • Gaudet R, Savage JR, McLaughlin JN, et al. (1999). "A molecular mechanism for the phosphorylation-dependent regulation of heterotrimeric G proteins by phosducin". Mol. Cell. 3 (5): 649–60. doi:10.1016/S1097-2765(00)80358-5. PMID 10360181.
  • Xu S, Ladak R, Swanson DA, et al. (2000). "PHR1 encodes an abundant, pleckstrin homology domain-containing integral membrane protein in the photoreceptor outer segments". J. Biol. Chem. 274 (50): 35676–85. doi:10.1074/jbc.274.50.35676. PMID 10585447.
  • Marin EP, Krishna AG, Zvyaga TA, et al. (2000). "The amino terminus of the fourth cytoplasmic loop of rhodopsin modulates rhodopsin-transducin interaction". J. Biol. Chem. 275 (3): 1930–6. doi:10.1074/jbc.275.3.1930. PMID 10636894.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Cuello F, Schulze RA, Heemeyer F, et al. (2003). "Activation of heterotrimeric G proteins by a high energy phosphate transfer via nucleoside diphosphate kinase (NDPK) B and Gbeta subunits. Complex formation of NDPK B with Gbeta gamma dimers and phosphorylation of His-266 IN Gbeta". J. Biol. Chem. 278 (9): 7220–6. doi:10.1074/jbc.M210304200. PMID 12486123.
  • Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology". Science. 300 (5620): 767–72. Bibcode:2003Sci...300..767S. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
  • Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. Bibcode:2003Natur.424..157H. doi:10.1038/nature01782. PMID 12853948.
  • Hinrichs MV, Montecino M, Bunster M, Olate J (2005). "Mutation of the highly conserved Arg165 and Glu168 residues of human Gsalpha disrupts the alphaD-alphaE loop and enhances basal GDP/GTP exchange rate". J. Cell. Biochem. 93 (2): 409–17. doi:10.1002/jcb.20193. PMID 15368366. S2CID 85626429.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Gao X, Sadana R, Dessauer CW, Patel TB (2007). "Conditional stimulation of type V and VI adenylyl cyclases by G protein betagamma subunits". J. Biol. Chem. 282 (1): 294–302. doi:10.1074/jbc.M607522200. PMID 17110384.
  • Seo M, Lee MJ, Heo JH, et al. (2007). "G Protein betagamma subunits augment UVB-induced apoptosis by stimulating the release of soluble heparin-binding epidermal growth factor from human keratinocytes". J. Biol. Chem. 282 (34): 24720–30. doi:10.1074/jbc.M702343200. PMID 17548351.

External links

  • Overview of all the structural information available in the PDB for UniProt: P02698 (Bovine Guanine nucleotide-binding protein G(T) subunit gamma-T1) at the PDBe-KB.
  • v
  • t
  • e
  • 1a0r: HETEROTRIMERIC COMPLEX OF PHOSDUCIN/TRANSDUCIN BETA-GAMMA
    1a0r: HETEROTRIMERIC COMPLEX OF PHOSDUCIN/TRANSDUCIN BETA-GAMMA
  • 1b9x: STRUCTURAL ANALYSIS OF PHOSDUCIN AND ITS PHOSPHORYLATION-REGULATED INTERACTION WITH TRANSDUCIN
    1b9x: STRUCTURAL ANALYSIS OF PHOSDUCIN AND ITS PHOSPHORYLATION-REGULATED INTERACTION WITH TRANSDUCIN
  • 1b9y: STRUCTURAL ANALYSIS OF PHOSDUCIN AND ITS PHOSPHORYLATION-REGULATED INTERACTION WITH TRANSDUCIN BETA-GAMMA
    1b9y: STRUCTURAL ANALYSIS OF PHOSDUCIN AND ITS PHOSPHORYLATION-REGULATED INTERACTION WITH TRANSDUCIN BETA-GAMMA
  • 1got: HETEROTRIMERIC COMPLEX OF A GT-ALPHA/GI-ALPHA CHIMERA AND THE GT-BETA-GAMMA SUBUNITS
    1got: HETEROTRIMERIC COMPLEX OF A GT-ALPHA/GI-ALPHA CHIMERA AND THE GT-BETA-GAMMA SUBUNITS
  • 1tbg: BETA-GAMMA DIMER OF THE HETEROTRIMERIC G-PROTEIN TRANSDUCIN
    1tbg: BETA-GAMMA DIMER OF THE HETEROTRIMERIC G-PROTEIN TRANSDUCIN
  • 2trc: PHOSDUCIN/TRANSDUCIN BETA-GAMMA COMPLEX
    2trc: PHOSDUCIN/TRANSDUCIN BETA-GAMMA COMPLEX
  • v
  • t
  • e
MAP
  • see MAP kinase pathway
Calcium
G protein
Heterotrimeric
cAMP:
cGMP:
Monomeric
Cyclin
Lipid
Other protein kinase
Serine/threonine:
Tyrosine:
Serine/threonine/tyrosine
Arginine
Other protein phosphatase
Serine/threonine:
Tyrosine:
both:
Apoptosis
  • see apoptosis signaling pathway
GTP-binding protein regulators
  • see GTP-binding protein regulators
Other
see also deficiencies of intracellular signaling peptides and proteins


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