GPR133

Protein-coding gene in the species Homo sapiens
ADGRD1
Identifiers
AliasesADGRD1, PGR25, GPR133, adhesion G protein-coupled receptor D1
External IDsOMIM: 613639 MGI: 3041203 HomoloGene: 34616 GeneCards: ADGRD1
Gene location (Human)
Chromosome 12 (human)
Chr.Chromosome 12 (human)[1]
Chromosome 12 (human)
Genomic location for ADGRD1
Genomic location for ADGRD1
Band12q24.33Start130,953,907 bp[1]
End131,141,469 bp[1]
Gene location (Mouse)
Chromosome 5 (mouse)
Chr.Chromosome 5 (mouse)[2]
Chromosome 5 (mouse)
Genomic location for ADGRD1
Genomic location for ADGRD1
Band5|5 G1.3Start129,173,814 bp[2]
End129,281,663 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • tibial nerve

  • right lung

  • sural nerve

  • upper lobe of left lung

  • gastric mucosa

  • gallbladder

  • canal of the cervix

  • Achilles tendon

  • left uterine tube

  • parietal pleura
Top expressed in
  • ankle joint

  • extraocular muscle

  • white adipose tissue

  • body of femur

  • sciatic nerve

  • ascending aorta

  • thoracic diaphragm

  • urinary bladder

  • pharynx

  • lip
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • G protein-coupled receptor activity
  • transmembrane signaling receptor activity
  • signal transducer activity
Cellular component
  • integral component of membrane
  • plasma membrane
  • membrane
  • intracellular anatomical structure
  • integral component of plasma membrane
Biological process
  • G protein-coupled receptor signaling pathway
  • cell surface receptor signaling pathway
  • signal transduction
  • adenylate cyclase-activating G protein-coupled receptor signaling pathway
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

283383

243277

Ensembl

ENSG00000111452

ENSMUSG00000044017

UniProt

Q6QNK2

Q80T32

RefSeq (mRNA)

NM_198827
NM_001330497

NM_001081342
NM_177734
NM_001347486

RefSeq (protein)

NP_001317426
NP_942122

NP_001074811
NP_001334415

Location (UCSC)Chr 12: 130.95 – 131.14 MbChr 5: 129.17 – 129.28 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Probable G-protein coupled receptor 133 is a protein that in humans is encoded by the GPR133 gene.[5][6]

This gene encodes a member of the adhesion-GPCR family of receptors. Family members are characterized by an extended extracellular region with a variable number of protein domains coupled to a TM7 domain via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.[7][8]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000111452 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000044017 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: GPR133 G protein-coupled receptor 133".
  6. ^ Fredriksson R, Lagerstrom MC, Hoglund PJ, Schioth HB (Nov 2002). "Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions". FEBS Lett. 531 (3): 407–14. doi:10.1016/S0014-5793(02)03574-3. PMID 12435584. S2CID 7449692.
  7. ^ Stacey M, Yona S (2011). AdhesionGPCRs: Structure to Function (Advances in Experimental Medicine and Biology). Berlin: Springer. ISBN 978-1-4419-7912-4.
  8. ^ Araç D, Boucard AA, Bolliger MF, Nguyen J, Soltis SM, Südhof TC, Brunger AT (March 2012). "A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis". EMBO J. 31 (6): 1364–78. doi:10.1038/emboj.2012.26. PMC 3321182. PMID 22333914.

Further reading

  • Vanti WB, Nguyen T, Cheng R, et al. (2003). "Novel human G-protein-coupled receptors". Biochem. Biophys. Res. Commun. 305 (1): 67–71. doi:10.1016/S0006-291X(03)00709-5. PMID 12732197.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Bjarnadóttir TK, Fredriksson R, Höglund PJ, et al. (2005). "The human and mouse repertoire of the adhesion family of G-protein-coupled receptors". Genomics. 84 (1): 23–33. doi:10.1016/j.ygeno.2003.12.004. PMID 15203201.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
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Neurotransmitter
Adrenergic
Purinergic
Serotonin
Other
Metabolites and
signaling molecules
Eicosanoid
Other
Peptide
Neuropeptide
Other
Miscellaneous
Taste, bitter
Orphan
Other
Adhesion
Orphan
Other
Taste, sweet
Other
Class F: Frizzled & Smoothened
Frizzled
Smoothened
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