GPR146

Protein-coding gene in the species Homo sapiens
GPR146
Identifiers
AliasesGPR146, PGR8, G protein-coupled receptor 146
External IDsMGI: 1933113 HomoloGene: 36472 GeneCards: GPR146
Gene location (Human)
Chromosome 7 (human)
Chr.Chromosome 7 (human)[1]
Chromosome 7 (human)
Genomic location for GPR146
Genomic location for GPR146
Band7p22.3Start1,044,546 bp[1]
End1,059,261 bp[1]
Gene location (Mouse)
Chromosome 5 (mouse)
Chr.Chromosome 5 (mouse)[2]
Chromosome 5 (mouse)
Genomic location for GPR146
Genomic location for GPR146
Band5|5 G2Start139,377,697 bp[2]
End139,396,415 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • subcutaneous adipose tissue

  • abdominal fat

  • gastric mucosa

  • right lung

  • tibial nerve

  • blood

  • left ventricle

  • body of stomach

  • upper lobe of left lung

  • left uterine tube
Top expressed in
  • interventricular septum

  • retinal pigment epithelium

  • myocardium of ventricle

  • left lobe of liver

  • right lung

  • triceps brachii muscle

  • right lung lobe

  • carotid body

  • skeletal muscle tissue

  • quadriceps femoris muscle
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • signal transducer activity
  • G protein-coupled receptor activity
Cellular component
  • plasma membrane
  • membrane
  • integral component of membrane
Biological process
  • G protein-coupled receptor signaling pathway
  • signal transduction
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

115330

80290

Ensembl

ENSG00000164849

ENSMUSG00000044197

UniProt

Q96CH1

Q99LE2

RefSeq (mRNA)

NM_001303473
NM_001303474
NM_138445

NM_001038703
NM_030258

RefSeq (protein)

NP_001290402
NP_001290403
NP_612454

NP_001033792
NP_084534
NP_001349135

Location (UCSC)Chr 7: 1.04 – 1.06 MbChr 5: 139.38 – 139.4 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Probable G-protein coupled receptor 146 is a protein that in humans is encoded by the GPR146 gene.[5] It has been identified as a possible receptor for C-peptide.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000164849 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000044197 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: GPR146 G protein-coupled receptor 146".
  6. ^ Yosten GL, Kolar GR, Redlinger LJ, Samson WK (11 July 2013). "Evidence for an interaction between proinsulin C-peptide and GPR146". The Journal of Endocrinology. 218 (2): B1-8. doi:10.1530/JOE-13-0203. PMID 23759446.

Further reading

  • Vassilatis DK, Hohmann JG, Zeng H, Li F, Ranchalis JE, Mortrud MT, Brown A, Rodriguez SS, Weller JR, Wright AC, Bergmann JE, Gaitanaris GA (Apr 2003). "The G protein-coupled receptor repertoires of human and mouse". Proceedings of the National Academy of Sciences of the United States of America. 100 (8): 4903–8. Bibcode:2003PNAS..100.4903V. doi:10.1073/pnas.0230374100. PMC 153653. PMID 12679517.
  • Gloriam DE, Schiöth HB, Fredriksson R (Apr 2005). "Nine new human Rhodopsin family G-protein coupled receptors: identification, sequence characterisation and evolutionary relationship". Biochimica et Biophysica Acta (BBA) - General Subjects. 1722 (3): 235–46. doi:10.1016/j.bbagen.2004.12.001. PMID 15777626.
  • v
  • t
  • e
  • v
  • t
  • e
Neurotransmitter
Adrenergic
Purinergic
Serotonin
Other
Metabolites and
signaling molecules
Eicosanoid
Other
Peptide
Neuropeptide
Other
Miscellaneous
Taste, bitter
Orphan
Other
Adhesion
Orphan
Other
Taste, sweet
Other
Class F: Frizzled & Smoothened
Frizzled
Smoothened