GPR148

Protein-coding gene in the species Homo sapiens
GPR148
Identifiers
AliasesGPR148, BTR, PGR6, G protein-coupled receptor 148
External IDsHomoloGene: 131347 GeneCards: GPR148
Gene location (Human)
Chromosome 2 (human)
Chr.Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for GPR148
Genomic location for GPR148
Band2q21.1Start130,729,070 bp[1]
End130,730,336 bp[1]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • islet of Langerhans

  • cerebellum

  • cerebellar hemisphere

  • pituitary gland

  • anterior pituitary

  • Brodmann area 9

  • hypothalamus

  • rectum

  • prefrontal cortex

  • stomach
    n/a
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • G protein-coupled receptor activity
  • signal transducer activity
Cellular component
  • integral component of membrane
  • plasma membrane
  • membrane
Biological process
  • G protein-coupled receptor signaling pathway
  • signal transduction
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

344561

n/a

Ensembl

ENSG00000173302

n/a

UniProt

Q8TDV2

n/a

RefSeq (mRNA)

NM_207364

n/a

RefSeq (protein)

NP_997247

n/a

Location (UCSC)Chr 2: 130.73 – 130.73 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

G protein-coupled receptor 148, also known as GPR148, is a human orphan receptor from GPCR superfamily.[3] It is expressed primarily in nervous system and testis. Is may be implicated in prostate cancer.

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000173302 – Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ "Entrez Gene: GPR148 G protein-coupled receptor 148".

Further reading

  • Takeda S, Kadowaki S, Haga T, et al. (2002). "Identification of G protein-coupled receptor genes from the human genome sequence". FEBS Lett. 520 (1–3): 97–101. doi:10.1016/S0014-5793(02)02775-8. PMID 12044878. S2CID 7116392.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Vassilatis DK, Hohmann JG, Zeng H, et al. (2003). "The G protein-coupled receptor repertoires of human and mouse". Proc. Natl. Acad. Sci. U.S.A. 100 (8): 4903–8. Bibcode:2003PNAS..100.4903V. doi:10.1073/pnas.0230374100. PMC 153653. PMID 12679517.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Parmigiani RB, Magalhães GS, Galante PA, et al. (2005). "A novel human G protein-coupled receptor is over-expressed in prostate cancer". Genet. Mol. Res. 3 (4): 521–31. PMID 15688318.
  • Gloriam DE, Schiöth HB, Fredriksson R (2005). "Nine new human Rhodopsin family G-protein coupled receptors: identification, sequence characterisation and evolutionary relationship". Biochim. Biophys. Acta. 1722 (3): 235–46. doi:10.1016/j.bbagen.2004.12.001. PMID 15777626.
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Neurotransmitter
Adrenergic
Purinergic
Serotonin
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Metabolites and
signaling molecules
Eicosanoid
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Peptide
Neuropeptide
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Miscellaneous
Taste, bitter
Orphan
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Adhesion
Orphan
Other
Taste, sweet
Other
Class F: Frizzled & Smoothened
Frizzled
Smoothened
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