GPR157

Protein-coding gene in the species Homo sapiens
GPR157
Identifiers
AliasesGPR157, G protein-coupled receptor 157
External IDsMGI: 2442046 HomoloGene: 18573 GeneCards: GPR157
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for GPR157
Genomic location for GPR157
Band1p36.22Start9,100,305 bp[1]
End9,129,102 bp[1]
Gene location (Mouse)
Chromosome 4 (mouse)
Chr.Chromosome 4 (mouse)[2]
Chromosome 4 (mouse)
Genomic location for GPR157
Genomic location for GPR157
Band4|4 E2Start150,171,822 bp[2]
End150,190,384 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • vastus lateralis muscle

  • gums

  • oral cavity

  • tibialis anterior muscle

  • deltoid muscle

  • gastrocnemius muscle

  • placenta

  • right ventricle

  • skin of abdomen

  • vulva
Top expressed in
  • quadriceps femoris muscle

  • muscle tissue

  • skeletal muscle tissue

  • lip

  • heart

  • zone of skin

  • yolk sac

  • esophagus

  • placenta

  • white adipose tissue
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • transmembrane signaling receptor activity
  • signal transducer activity
  • G protein-coupled receptor activity
Cellular component
  • integral component of membrane
  • plasma membrane
  • membrane
  • ciliary membrane
  • cell projection
Biological process
  • cell surface receptor signaling pathway
  • signal transduction
  • G protein-coupled receptor signaling pathway
  • circadian behavior
  • positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway
  • radial glial cell differentiation
  • multicellular organism development
  • cell differentiation
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

80045

269604

Ensembl

ENSG00000180758

ENSMUSG00000047875

UniProt

Q5UAW9

Q8C206

RefSeq (mRNA)

NM_024980

NM_177366

RefSeq (protein)

NP_079256

NP_796340

Location (UCSC)Chr 1: 9.1 – 9.13 MbChr 4: 150.17 – 150.19 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Probable G-protein coupled receptor 157 is a protein that in humans is encoded by the GPR157 gene.[5][6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000180758 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000047875 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Hirosawa M, Nagase T, Ishikawa K, Kikuno R, Nomura N, Ohara O (Jan 2000). "Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain". DNA Res. 6 (5): 329–36. doi:10.1093/dnares/6.5.329. PMID 10574461.
  6. ^ "Entrez Gene: GPR157 G protein-coupled receptor 157".

Further reading

  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
  • Takeo Y, Kurabayashi N, Nguyen MD, Sanada K, et al. (2016). "The G protein-coupled receptor GPR157 regulates neuronal differentiation of radial glial progenitors through the Gq-IP3 pathway". Scientific Reports. 6: 25180–92. Bibcode:2016NatSR...625180T. doi:10.1038/srep25180. PMC 4855140. PMID 27142930.
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