GPR162

Protein-coding gene in the species Homo sapiens
GPR162
Identifiers
AliasesGPR162, A-2, GRCA, G protein-coupled receptor 162
External IDsMGI: 1315214 HomoloGene: 8400 GeneCards: GPR162
Gene location (Human)
Chromosome 12 (human)
Chr.Chromosome 12 (human)[1]
Chromosome 12 (human)
Genomic location for GPR162
Genomic location for GPR162
Band12p13.31Start6,821,624 bp[1]
End6,829,972 bp[1]
Gene location (Mouse)
Chromosome 6 (mouse)
Chr.Chromosome 6 (mouse)[2]
Chromosome 6 (mouse)
Genomic location for GPR162
Genomic location for GPR162
Band6 F2|6 59.17 cMStart124,835,407 bp[2]
End124,840,946 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • cingulate gyrus

  • prefrontal cortex

  • right uterine tube

  • Brodmann area 9

  • amygdala

  • anterior pituitary

  • nucleus accumbens

  • caudate nucleus

  • hippocampus proper

  • hypothalamus
Top expressed in
  • entorhinal cortex

  • superior frontal gyrus

  • cerebellar cortex

  • superior colliculus

  • primary motor cortex

  • hippocampus proper

  • subiculum

  • prefrontal cortex

  • inferior colliculus

  • lateral geniculate nucleus
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • G protein-coupled receptor activity
  • signal transducer activity
Cellular component
  • integral component of membrane
  • plasma membrane
  • membrane
Biological process
  • G protein-coupled receptor signaling pathway
  • signal transduction
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

27239

14788

Ensembl

ENSG00000250510

ENSMUSG00000038390

UniProt

Q16538

Q3UN16

RefSeq (mRNA)

NM_019858
NM_014449

NM_013533
NM_001355257

RefSeq (protein)

NP_055264
NP_062832

NP_038561
NP_001342186

Location (UCSC)Chr 12: 6.82 – 6.83 MbChr 6: 124.84 – 124.84 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Probable G-protein coupled receptor 162 is a protein that in humans is encoded by the GPR162 gene.[5][6]

This gene was identified upon genomic analysis of a gene-dense region at human chromosome 12p13. It appears to be mainly expressed in the brain; however, its function is not known. Alternatively spliced transcript variants encoding different isoforms have been identified.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000250510 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000038390 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Gloriam DE, Schioth HB, Fredriksson R (Apr 2005). "Nine new human Rhodopsin family G-protein coupled receptors: identification, sequence characterisation and evolutionary relationship". Biochim Biophys Acta. 1722 (3): 235–46. doi:10.1016/j.bbagen.2004.12.001. PMID 15777626.
  6. ^ a b "Entrez Gene: GPR162 G protein-coupled receptor 162".

Further reading

  • Ansari-Lari MA, Muzny DM, Lu J, et al. (1996). "A gene-rich cluster between the CD4 and triosephosphate isomerase genes at human chromosome 12p13". Genome Res. 6 (4): 314–26. doi:10.1101/gr.6.4.314. PMID 8723724.
  • Ansari-Lari MA, Shen Y, Muzny DM, et al. (1997). "Large-scale sequencing in human chromosome 12p13: experimental and computational gene structure determination". Genome Res. 7 (3): 268–80. doi:10.1101/gr.7.3.268. PMID 9074930.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
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