GPR19

Protein-coding gene in the species Homo sapiens

GPR19

Identifiers

Aliases

GPR19, G protein-coupled receptor 19

External IDs

OMIM: 602927 MGI: 892973 HomoloGene: 4476 GeneCards: GPR19

Gene location (Human)

Chr.	Chromosome 12 (human)^[1]

Band	12p13.1	Start	12,660,890 bp^[1]
Band	12p13.1	End	12,696,207 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 6 (mouse)^[2]

Band	6\|6 G1	Start	134,846,056 bp^[2]
Band	6\|6 G1	End	134,875,541 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

Brodmann area 23

endothelial cell

middle temporal gyrus

ganglionic eminence

cerebellar hemisphere

pituitary gland

prefrontal cortex

nucleus accumbens

Brodmann area 46

hypothalamus

Top expressed in

spermatocyte

medial ganglionic eminence

spermatid

humerus

seminiferous tubule

pituitary gland

fibula

suprachiasmatic nucleus

Meckel's cartilage

median eminence

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	signal transducer activity G protein-coupled receptor activity
Cellular component	integral component of plasma membrane membrane integral component of membrane plasma membrane cilium
Biological process	signal transduction G protein-coupled receptor signaling pathway neuropeptide signaling pathway chemical synaptic transmission feeding behavior
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


2842


14760

Ensembl


ENSG00000183150


ENSMUSG00000032641

UniProt


Q15760


Q61121

RefSeq (mRNA)


NM_006143

NM_001167693 NM_001167694 NM_001167695 NM_001167696 NM_001167697
NM_001167699 NM_001167700 NM_008157 NM_001362048 NM_001362049 NM_001362050 NM_001362051 NM_001362052

RefSeq (protein)


NP_006134

NP_001161166 NP_001161167 NP_001161168 NP_001161169 NP_001161171
NP_001161172 NP_032183 NP_001348977 NP_001348978 NP_001348979 NP_001348980 NP_001348981

Location (UCSC)

Chr 12: 12.66 – 12.7 Mb

Chr 6: 134.85 – 134.88 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Probable G-protein coupled receptor 19 is a protein that in humans is encoded by the GPR19 gene.^[5] GPR19 has been proposed as the receptor for the peptide hormone adropin.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000183150 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000032641 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: GPR19 G protein-coupled receptor 19".
^ Stein, Lauren M.; Yosten, Gina L. C.; Samson, Willis K. (2016-03-15). "Adropin acts in brain to inhibit water drinking: potential interaction with the orphan G protein-coupled receptor, GPR19". American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 310 (6): R476–R480. doi:10.1152/ajpregu.00511.2015. ISSN 0363-6119. PMC 4867374. PMID 26739651.

O'Dowd BF, Nguyen T, Lynch KR, et al. (1996). "A novel gene codes for a putative G protein-coupled receptor with an abundant expression in brain". FEBS Lett. 394 (3): 325–9. doi:10.1016/0014-5793(96)00901-5. PMID 8830667. S2CID 1484916.
Montpetit A, Sinnett D (1999). "Physical mapping of the G-protein coupled receptor 19 (GPR19) in the chromosome 12p12.3 region frequently rearranged in cancer cells". Hum. Genet. 105 (1–2): 162–4. doi:10.1007/s004390051080. PMID 10480372.
Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.

Cell surface receptor: G protein-coupled receptors

Class A: Rhodopsin-like

Neurotransmitter

Adrenergic	α1 (A B D) α2 (A B C) β1 β2 β3
Purinergic	Adenosine (A1 A2A A2B A3) P2Y (1 2 4 5 6 8 9 10 11 12 13 14)
Serotonin	(all but 5-HT3) 5-HT1 (A B D E F) 5-HT2 (A B C) 5-HT (4 5A 6 7)
Other	Acetylcholine (M1 M2 M3 M4 M5) Dopamine D1 D2 D3 D4 D5 GHB receptor Histamine H1 H2 H3 H4 Melatonin (1A 1B 1C) TAAR (1 2 5 6 8 9)

Metabolites and
signaling molecules

Eicosanoid	CysLT (1 2) LTB4 1 2 FPRL1 OXE Prostaglandin DP (1 2), EP (1 2 3 4), FP Prostacyclin Thromboxane
Other	Bile acid Cannabinoid (CB1 CB2, GPR (18 55 119)) EBI2 Estrogen Free fatty acid (1 2 3 4) Hydroxycarboxylic acids 1 2 3 Lysophosphatidic acid (1 2 3 4 5 6) Lysophospholipid (1 2 3 4 5 6 7 8) Oxoglutarate PAF Sphingosine-1-phosphate (1 2 3 4 5) Succinate

Peptide

Neuropeptide

B/W (1
2)
FF (1
2)
S
Y (1
2
4
5)
Neuromedin (B
U (1
2))
Neurotensin (1
2)

Other

Anaphylatoxin (C3a
C5a (1
2))
Angiotensin (1
2)
Apelin
Bombesin
- BRS3
- GRPR
- NMBR)
- Bradykinin (B1
- B2)
Chemokine
Cholecystokinin (A
B)
Endothelin
- A
- B
Formyl peptide (1
2
3)
FSH
Galanin (1
2
3)
Gonadotropin-releasing hormone (1
2)
Ghrelin
Kisspeptin
Luteinizing hormone/choriogonadotropin
MAS (1
1L
D
E
F
G
X1
X2
X3
X4)
Melanocortin (1
2
3
4
5)
MCHR (1
2)
Motilin
Opioid (Delta
Kappa
Mu
Nociceptin & Zeta, but not Sigma)
Orexin (1
2)
Oxytocin
Prokineticin (1
2)
Prolactin-releasing peptide
Relaxin (1
2
3
4)
Somatostatin (1
2
3
4
5)
Tachykinin (1
2
3)
Thyrotropin
Thyrotropin-releasing hormone
Urotensin-II
Vasopressin (1A
1B
2)

Miscellaneous

Taste, bitter	TAS2R 1 3 4 5 7 8 9 10 13 14 16 19 20 30 31 38 39 40 41 42 43 45 46 50 60 Vomeronasal receptor type 1
Orphan	GPR (1 3 4 6 12 15 17 18 19 20 21 22 23 25 26 27 31 32 33 34 35 37 39 42 44 45 50 52 55 61 62 63 65 68 75 78 81 82 83 84 85 87 88 92 101 103 109A 109B 119 120 132 135 137B 139 141 142 146 148 149 150 151 152 153 160 161 162 171 173 174 176 177 182 183)
Other	Adrenomedullin Olfactory Opsin (3 4 5 1LW 1MW 1SW RGR RRH) Protease-activated (1 2 3 4) SREB (1 2 3)

Class B: Secretin-like

Adhesion	ADGRB Brain-specific angiogenesis inhibitor 1 2 3 ADGRC Cadherin 1 2 3 ADGRE EMR 1 2 3 CD97 ADGRG 1 2 3 4 5 6 7 ADGRL Latrophilin 1 2 3 ELTD1
Orphan	GPR (56 64 97 98 110 111 112 113 114 115 116 123 124 125 126 128 133 143 144 155 157)
Other	Calcitonin CALCRL Corticotropin-releasing hormone (1 2) Glucagon (GR GIPR GLP1R GLP2R) Growth-hormone-releasing hormone PACAPR1 GPR Methuselah-like proteins Parathyroid hormone (1 2) Secretin Vasoactive intestinal peptide (1 2)

Class C: Metabotropic glutamate / pheromone

Taste, sweet	TAS1R 1 2 3 Vomeronasal receptor, type 2
Other	Calcium-sensing receptor GABA_B (1 2) Glutamate receptor (Metabotropic glutamate (1 2 3 4 5 6 7 8)) GPRC6A GPR (156 158 179) RAIG (1 2 3 4)