GPR62

Protein-coding gene in the species Homo sapiens
GPR62
Identifiers
AliasesGPR62, GPCR8, KPG_005, G protein-coupled receptor 62
External IDsOMIM: 606917 MGI: 3525078 HomoloGene: 50962 GeneCards: GPR62
Gene location (Human)
Chromosome 3 (human)
Chr.Chromosome 3 (human)[1]
Chromosome 3 (human)
Genomic location for GPR62
Genomic location for GPR62
Band3p21.2Start51,955,381 bp[1]
End51,957,499 bp[1]
Gene location (Mouse)
Chromosome 9 (mouse)
Chr.Chromosome 9 (mouse)[2]
Chromosome 9 (mouse)
Genomic location for GPR62
Genomic location for GPR62
Band9|9 F1Start106,341,161 bp[2]
End106,343,137 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • inferior ganglion of vagus nerve

  • internal globus pallidus

  • subthalamic nucleus

  • endothelial cell

  • ventral tegmental area

  • corpus callosum

  • substantia nigra

  • external globus pallidus

  • medulla oblongata

  • putamen
Top expressed in
  • seminiferous tubule

  • substantia nigra

  • anterior horn of spinal cord

  • suprachiasmatic nucleus

  • pontine nuclei

  • lateral geniculate nucleus

  • spermatocyte

  • ventral tegmental area

  • spermatid

  • dorsal tegmental nucleus
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • G protein-coupled receptor activity
  • signal transducer activity
  • protein binding
  • identical protein binding
  • arrestin family protein binding
Cellular component
  • integral component of membrane
  • receptor complex
  • membrane
  • plasma membrane
  • endosome
  • endosome membrane
Biological process
  • signal transduction
  • G protein-coupled receptor signaling pathway
  • positive regulation of cAMP-mediated signaling
  • inositol phosphate-mediated signaling
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

118442

436090

Ensembl

ENSG00000180929

ENSMUSG00000091735

UniProt

Q9BZJ7

Q80UC6

RefSeq (mRNA)

NM_080865

NM_001159652

RefSeq (protein)

NP_543141

NP_001153124

Location (UCSC)Chr 3: 51.96 – 51.96 MbChr 9: 106.34 – 106.34 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Probable G-protein coupled receptor 62 is a protein that in humans is encoded by the GPR62 gene.[5][6]

G protein–coupled receptors (GPCRs, or GPRs) contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins.[supplied by OMIM][6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000180929 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000091735 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Lee DK, George SR, Cheng R, Nguyen T, Liu Y, Brown M, Lynch KR, O'Dowd BF (Feb 2001). "Identification of four novel human G protein-coupled receptors expressed in the brain". Brain Res Mol Brain Res. 86 (1–2): 13–22. doi:10.1016/S0169-328X(00)00242-4. PMID 11165367.
  6. ^ a b "Entrez Gene: GPR62 G protein-coupled receptor 62".

Further reading

  • Takeda S, Kadowaki S, Haga T, et al. (2002). "Identification of G protein-coupled receptor genes from the human genome sequence". FEBS Lett. 520 (1–3): 97–101. doi:10.1016/S0014-5793(02)02775-8. PMID 12044878. S2CID 7116392.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
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