GRIN3A

Protein-coding gene in the species Homo sapiens
GRIN3A
Identifiers
AliasesGRIN3A, GluN3A, NMDAR-L, NR3A, glutamate ionotropic receptor NMDA type subunit 3A, NMDAR3A
External IDsOMIM: 606650 MGI: 1933206 HomoloGene: 128613 GeneCards: GRIN3A
Gene location (Human)
Chromosome 9 (human)
Chr.Chromosome 9 (human)[1]
Chromosome 9 (human)
Genomic location for GRIN3A
Genomic location for GRIN3A
Band9q31.1Start101,569,352 bp[1]
End101,738,647 bp[1]
Gene location (Mouse)
Chromosome 4 (mouse)
Chr.Chromosome 4 (mouse)[2]
Chromosome 4 (mouse)
Genomic location for GRIN3A
Genomic location for GRIN3A
Band4|4 B1Start49,661,611 bp[2]
End49,845,744 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • Brodmann area 46

  • middle temporal gyrus

  • Brodmann area 23

  • prefrontal cortex

  • entorhinal cortex

  • dorsolateral prefrontal cortex

  • cingulate gyrus

  • superior frontal gyrus

  • Brodmann area 9

  • hypothalamus
Top expressed in
  • subiculum

  • habenula

  • dorsomedial hypothalamic nucleus

  • supraoptic nucleus

  • paraventricular nucleus of hypothalamus

  • medial dorsal nucleus

  • pontine nuclei

  • superior colliculus

  • ventral tegmental area

  • Region I of hippocampus proper
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • glycine binding
  • identical protein binding
  • protein phosphatase 2A binding
  • ion channel activity
  • extracellularly glutamate-gated ion channel activity
  • calcium channel activity
  • ionotropic glutamate receptor activity
  • protein binding
  • NMDA glutamate receptor activity
  • signaling receptor activity
  • transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential
Cellular component
  • synapse
  • integral component of membrane
  • NMDA selective glutamate receptor complex
  • cell junction
  • neuron projection
  • postsynaptic density
  • postsynaptic membrane
  • membrane
  • neuronal cell body
  • plasma membrane
  • glutamatergic synapse
Biological process
  • calcium ion transport
  • dendrite development
  • response to ethanol
  • prepulse inhibition
  • ion transport
  • calcium ion transmembrane transport
  • ionotropic glutamate receptor signaling pathway
  • ion transmembrane transport
  • excitatory postsynaptic potential
  • signal transduction
  • regulation of postsynaptic membrane potential
  • regulation of synaptic vesicle exocytosis
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

116443

242443

Ensembl

ENSG00000198785

ENSMUSG00000039579

UniProt

Q8TCU5

A2AIR5

RefSeq (mRNA)

NM_133445

NM_001033351
NM_001276355

RefSeq (protein)

NP_597702

NP_001028523
NP_001263284

Location (UCSC)Chr 9: 101.57 – 101.74 MbChr 4: 49.66 – 49.85 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Glutamate [NMDA] receptor subunit 3A is a protein that in humans is encoded by the GRIN3A gene.[5]

Function

This gene encodes a subunit of the N-methyl-D-aspartate (NMDAR) receptors, which belong to the superfamily of glutamate-regulated ion channels, and function in physiological and pathological processes in the central nervous system. This subunit shows greater than 90% identity to the corresponding subunit in rat. Studies in the knockout mouse deficient in this subunit suggest that this gene may be involved in the development of synaptic elements by modulating NMDA receptor activity.[5]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000198785 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000039579 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: GRIN3A glutamate receptor, ionotropic, N-methyl-D-aspartate 3A".

Further reading

  • Schröder HC, Perovic S, Kavsan V, Ushijima H, Müller WE (1998). "Mechanisms of prionSc- and HIV-1 gp120 induced neuronal cell death". Neurotoxicology. 19 (4–5): 683–8. PMID 9745929.
  • Eriksson M, Nilsson A, Samuelsson H, Samuelsson EB, Mo L, Akesson E, Benedikz E, Sundström E (2007). "On the role of NR3A in human NMDA receptors". Physiol. Behav. 92 (1–2): 54–9. doi:10.1016/j.physbeh.2007.05.026. PMID 17617428. S2CID 21646700.
  • Kornau HC, Schenker LT, Kennedy MB, Seeburg PH (1995). "Domain interaction between NMDA receptor subunits and the postsynaptic density protein PSD-95". Science. 269 (5231): 1737–40. Bibcode:1995Sci...269.1737K. doi:10.1126/science.7569905. PMID 7569905.
  • Magnuson DS, Knudsen BE, Geiger JD, Brownstone RM, Nath A (1995). "Human immunodeficiency virus type 1 tat activates non-N-methyl-D-aspartate excitatory amino acid receptors and causes neurotoxicity". Ann. Neurol. 37 (3): 373–80. doi:10.1002/ana.410370314. PMID 7695237. S2CID 24405132.
  • Lannuzel A, Lledo PM, Lamghitnia HO, Vincent JD, Tardieu M (1996). "HIV-1 envelope proteins gp120 and gp160 potentiate NMDA-induced [Ca2+]i increase, alter [Ca2+]i homeostasis and induce neurotoxicity in human embryonic neurons". Eur. J. Neurosci. 7 (11): 2285–93. doi:10.1111/j.1460-9568.1995.tb00649.x. PMID 8563977. S2CID 27201873.
  • Corasaniti MT, Melino G, Navarra M, Garaci E, Finazzi-Agrò A, Nisticò G (1996). "Death of cultured human neuroblastoma cells induced by HIV-1 gp120 is prevented by NMDA receptor antagonists and inhibitors of nitric oxide and cyclooxygenase". Neurodegeneration. 4 (3): 315–21. doi:10.1016/1055-8330(95)90021-7. PMID 8581564.
  • Pittaluga A, Pattarini R, Severi P, Raiteri M (1996). "Human brain N-methyl-D-aspartate receptors regulating noradrenaline release are positively modulated by HIV-1 coat protein gp120". AIDS. 10 (5): 463–8. doi:10.1097/00002030-199605000-00003. PMID 8724036. S2CID 1669986.
  • Wu P, Price P, Du B, Hatch WC, Terwilliger EF (1996). "Direct cytotoxicity of HIV-1 envelope protein gp120 on human NT neurons". NeuroReport. 7 (5): 1045–9. doi:10.1097/00001756-199604100-00018. PMID 8804048. S2CID 21018147.
  • Bennett BA, Rusyniak DE, Hollingsworth CK (1996). "HIV-1 gp120-induced neurotoxicity to midbrain dopamine cultures". Brain Res. 705 (1–2): 168–76. doi:10.1016/0006-8993(95)01166-8. PMID 8821747. S2CID 32822686.
  • Toggas SM, Masliah E, Mucke L (1996). "Prevention of HIV-1 gp120-induced neuronal damage in the central nervous system of transgenic mice by the NMDA receptor antagonist memantine". Brain Res. 706 (2): 303–7. doi:10.1016/0006-8993(95)01197-8. PMID 8822372. S2CID 44260060.
  • Dreyer EB, Lipton SA (1996). "The coat protein gp120 of HIV-1 inhibits astrocyte uptake of excitatory amino acids via macrophage arachidonic acid". Eur. J. Neurosci. 7 (12): 2502–7. doi:10.1111/j.1460-9568.1995.tb01048.x. PMID 8845955. S2CID 7370984.
  • Raber J, Toggas SM, Lee S, Bloom FE, Epstein CJ, Mucke L (1997). "Central nervous system expression of HIV-1 Gp120 activates the hypothalamic-pituitary-adrenal axis: evidence for involvement of NMDA receptors and nitric oxide synthase". Virology. 226 (2): 362–73. doi:10.1006/viro.1996.0664. PMID 8955056.
  • Das S, Sasaki YF, Rothe T, Premkumar LS, Takasu M, Crandall JE, Dikkes P, Conner DA, Rayudu PV, Cheung W, Chen HS, Lipton SA, Nakanishi N (1998). "Increased NMDA current and spine density in mice lacking the NMDA receptor subunit NR3A". Nature. 393 (6683): 377–81. Bibcode:1998Natur.393..377D. doi:10.1038/30748. PMID 9620802. S2CID 4391270.
  • New DR, Maggirwar SB, Epstein LG, Dewhurst S, Gelbard HA (1998). "HIV-1 Tat induces neuronal death via tumor necrosis factor-alpha and activation of non-N-methyl-D-aspartate receptors by a NFkappaB-independent mechanism". J. Biol. Chem. 273 (28): 17852–8. doi:10.1074/jbc.273.28.17852. PMID 9651389.
  • Wang P, Barks JD, Silverstein FS (1999). "Tat, a human immunodeficiency virus-1-derived protein, augments excitotoxic hippocampal injury in neonatal rats". Neuroscience. 88 (2): 585–97. doi:10.1016/S0306-4522(98)00242-5. PMID 10197777. S2CID 28927942.
  • Howard SA, Nakayama AY, Brooke SM, Sapolsky RM (1999). "Glucocorticoid modulation of gp120-induced effects on calcium-dependent degenerative events in primary hippocampal and cortical cultures". Exp. Neurol. 158 (1): 164–70. doi:10.1006/exnr.1999.7080. PMID 10448428. S2CID 7598117.
  • Xin KQ, Hamajima K, Hattori S, Cao XR, Kawamoto S, Okuda K (1999). "Evidence of HIV type 1 glycoprotein 120 binding to recombinant N-methyl-D-aspartate receptor subunits expressed in a baculovirus system". AIDS Res. Hum. Retroviruses. 15 (16): 1461–7. doi:10.1089/088922299309973. PMID 10555109.
  • Perez-Otano I, Schulteis CT, Contractor A, Lipton SA, Trimmer JS, Sucher NJ, Heinemann SF (2001). "Assembly with the NR1 subunit is required for surface expression of NR3A-containing NMDA receptors". J. Neurosci. 21 (4): 1228–37. doi:10.1523/JNEUROSCI.21-04-01228.2001. PMC 6762235. PMID 11160393.
  • Haughey NJ, Nath A, Mattson MP, Slevin JT, Geiger JD (2001). "HIV-1 Tat through phosphorylation of NMDA receptors potentiates glutamate excitotoxicity". J. Neurochem. 78 (3): 457–67. doi:10.1046/j.1471-4159.2001.00396.x. PMID 11483648. S2CID 25641791.

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