GSG2

Protein-coding gene in the species Homo sapiens
HASPIN
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2VUW, 2WB8, 3DLZ, 3E7V, 3F2N, 3FMD, 3IQ7, 4OUC, 4QTC, 5HTC, 5HTB

Identifiers
AliasesHASPIN, GSG2, germ cell associated 2, haspin, histone H3 associated protein kinase
External IDsOMIM: 609240 MGI: 1194498 HomoloGene: 49236 GeneCards: HASPIN
Gene location (Human)
Chromosome 17 (human)
Chr.Chromosome 17 (human)[1]
Chromosome 17 (human)
Genomic location for HASPIN
Genomic location for HASPIN
Band17p13.2Start3,723,903 bp[1]
End3,726,699 bp[1]
Gene location (Mouse)
Chromosome 11 (mouse)
Chr.Chromosome 11 (mouse)[2]
Chromosome 11 (mouse)
Genomic location for HASPIN
Genomic location for HASPIN
Band11 B4|11 45.25 cMStart73,026,311 bp[2]
End73,029,120 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • pancreatic ductal cell

  • secondary oocyte

  • tibialis anterior muscle

  • ganglionic eminence

  • bone marrow cells

  • sperm

  • stromal cell of endometrium

  • appendix

  • lymph node

  • rectum
Top expressed in
  • spermatid

  • seminiferous tubule

  • spermatocyte

  • secondary oocyte

  • primitive streak

  • abdominal wall

  • otic placode

  • morula

  • thymus

  • yolk sac
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • transferase activity
  • nucleotide binding
  • kinase activity
  • protein serine/threonine kinase activity
  • protein binding
  • histone kinase activity (H3-T3 specific)
  • ATP binding
  • protein kinase activity
Cellular component
  • cytoplasm
  • centrosome
  • chromosome
  • cytoskeleton
  • nucleus
  • spindle
Biological process
  • intracellular signal transduction
  • phosphorylation
  • mitotic sister chromatid cohesion
  • protein localization to chromosome, centromeric region
  • cell cycle
  • protein phosphorylation
  • chromatin organization
  • mitotic cell cycle
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

83903

14841

Ensembl

ENSG00000177602

ENSMUSG00000050107

UniProt

Q8TF76

Q9Z0R0

RefSeq (mRNA)

NM_031965

NM_010353

RefSeq (protein)

NP_114171

NP_034483

Location (UCSC)Chr 17: 3.72 – 3.73 MbChr 11: 73.03 – 73.03 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Serine/threonine-protein kinase haspin is an enzyme that in humans is encoded by the GSG2 gene.[5]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000177602 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000050107 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: GSG2 germ cell associated 2 (haspin)".

Further reading

  • Dai J, Sullivan BA, Higgins JM (2007). "Regulation of mitotic chromosome cohesion by Haspin and Aurora B." Dev. Cell. 11 (5): 741–50. doi:10.1016/j.devcel.2006.09.018. PMID 17084365.
  • Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. Bibcode:2006PNAS..103.5391N. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
  • Dai J, Sultan S, Taylor SS, Higgins JM (2005). "The kinase haspin is required for mitotic histone H3 Thr 3 phosphorylation and normal metaphase chromosome alignment". Genes Dev. 19 (4): 472–88. doi:10.1101/gad.1267105. PMC 548948. PMID 15681610.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Higgins JM (2001). "The Haspin gene: location in an intron of the integrin alphaE gene, associated transcription of an integrin alphaE-derived RNA and expression in diploid as well as haploid cells". Gene. 267 (1): 55–69. doi:10.1016/S0378-1119(01)00387-0. PMID 11311556.
  • Tanaka H, Iguchi N, Nakamura Y, et al. (2001). "Cloning and characterization of human haspin gene encoding haploid germ cell-specific nuclear protein kinase". Mol. Hum. Reprod. 7 (3): 211–8. doi:10.1093/molehr/7.3.211. PMID 11228240.


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