GTF2H4

Protein-coding gene in the species Homo sapiens
GTF2H4
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

5IY9, 5IVW, 5IY7, 5IY8, 5IY6

Identifiers
AliasesGTF2H4, general transcription factor IIH, polypeptide 4, 52kDa, P52, TFB2, TFIIH, general transcription factor IIH subunit 4
External IDsOMIM: 601760 MGI: 1338799 HomoloGene: 7090 GeneCards: GTF2H4
Gene location (Human)
Chromosome 6 (human)
Chr.Chromosome 6 (human)[1]
Chromosome 6 (human)
Genomic location for GTF2H4
Genomic location for GTF2H4
Band6p21.33Start30,908,207 bp[1]
End30,914,106 bp[1]
Gene location (Mouse)
Chromosome 17 (mouse)
Chr.Chromosome 17 (mouse)[2]
Chromosome 17 (mouse)
Genomic location for GTF2H4
Genomic location for GTF2H4
Band17|17 B1Start35,978,622 bp[2]
End35,984,631 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • right lobe of liver

  • pituitary gland

  • anterior pituitary

  • left lobe of thyroid gland

  • right lobe of thyroid gland

  • right coronary artery

  • tibial nerve

  • smooth muscle tissue

  • left coronary artery

  • fundus
Top expressed in
  • thymus

  • otic placode

  • spermatocyte

  • saccule

  • abdominal wall

  • maxillary prominence

  • facial motor nucleus

  • primitive streak

  • yolk sac

  • somite
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • protein kinase activity
  • ATP-dependent activity, acting on DNA
  • DNA-binding transcription factor activity
  • DNA helicase activity
  • protein binding
  • RNA polymerase II CTD heptapeptide repeat kinase activity
  • double-stranded DNA binding
  • ATPase activator activity
  • RNA polymerase II general transcription initiation factor activity
Cellular component
  • nucleoplasm
  • transcription factor TFIIH holo complex
  • core TFIIH complex portion of holo TFIIH complex
  • transcription factor TFIIH core complex
  • nucleus
  • transcription factor TFIID complex
  • nuclear speck
Biological process
  • termination of RNA polymerase I transcription
  • regulation of transcription, DNA-templated
  • phosphorylation of RNA polymerase II C-terminal domain
  • transcription initiation from RNA polymerase I promoter
  • transcription elongation from RNA polymerase II promoter
  • 7-methylguanosine mRNA capping
  • transcription by RNA polymerase II
  • transcription, DNA-templated
  • cellular response to DNA damage stimulus
  • global genome nucleotide-excision repair
  • transcription-coupled nucleotide-excision repair
  • transcription initiation from RNA polymerase II promoter
  • nucleotide-excision repair, DNA incision
  • DNA repair
  • nucleotide-excision repair
  • nucleotide-excision repair, preincision complex stabilization
  • nucleotide-excision repair, preincision complex assembly
  • nucleotide-excision repair, DNA incision, 5'-to lesion
  • DNA duplex unwinding
  • positive regulation of ATP-dependent activity
  • nucleotide-excision repair, DNA duplex unwinding
  • nucleotide-excision repair, DNA incision, 3'-to lesion
  • transcription elongation from RNA polymerase I promoter
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

2968

14885

Ensembl

ENSG00000213780

ENSMUSG00000001524

UniProt

Q92759

O70422

RefSeq (mRNA)

NM_001517

NM_010364

RefSeq (protein)

NP_001508

NP_034494

Location (UCSC)Chr 6: 30.91 – 30.91 MbChr 17: 35.98 – 35.98 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

General transcription factor IIH subunit 4 is a protein that in humans is encoded by the GTF2H4 gene.[5][6]

Interactions

GTF2H4 has been shown to interact with:

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000213780 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000001524 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b Marinoni JC, Roy R, Vermeulen W, Miniou P, Lutz Y, Weeda G, Seroz T, Gomez DM, Hoeijmakers JH, Egly JM (Apr 1997). "Cloning and characterization of p52, the fifth subunit of the core of the transcription/DNA repair factor TFIIH". EMBO J. 16 (5): 1093–102. doi:10.1093/emboj/16.5.1093. PMC 1169708. PMID 9118947.
  6. ^ "Entrez Gene: GTF2H4 general transcription factor IIH, polypeptide 4, 52kDa".
  7. ^ a b c d e Scully R, Anderson SF, Chao DM, Wei W, Ye L, Young RA, Livingston DM, Parvin JD (May 1997). "BRCA1 is a component of the RNA polymerase II holoenzyme". Proc. Natl. Acad. Sci. U.S.A. 94 (11): 5605–10. Bibcode:1997PNAS...94.5605S. doi:10.1073/pnas.94.11.5605. PMC 20825. PMID 9159119.
  8. ^ Giglia-Mari G, Coin F, Ranish JA, Hoogstraten D, Theil A, Wijgers N, Jaspers NG, Raams A, Argentini M, van der Spek PJ, Botta E, Stefanini M, Egly JM, Aebersold R, Hoeijmakers JH, Vermeulen W (Jul 2004). "A new, tenth subunit of TFIIH is responsible for the DNA repair syndrome trichothiodystrophy group A". Nat. Genet. 36 (7): 714–9. doi:10.1038/ng1387. PMID 15220921.

Further reading

  • Jeang KT (1998). "Tat, Tat-associated kinase, and transcription". J. Biomed. Sci. 5 (1): 24–7. doi:10.1007/BF02253352. PMID 9570510.
  • Yankulov K, Bentley D (1998). "Transcriptional control: Tat cofactors and transcriptional elongation". Curr. Biol. 8 (13): R447-9. Bibcode:1998CBio....8.R447Y. doi:10.1016/S0960-9822(98)70289-1. PMID 9651670. S2CID 15480646.
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Blau J, Xiao H, McCracken S, O'Hare P, Greenblatt J, Bentley D (1996). "Three functional classes of transcriptional activation domain". Mol. Cell. Biol. 16 (5): 2044–55. doi:10.1128/MCB.16.5.2044. PMC 231191. PMID 8628270.
  • Drapkin R, Le Roy G, Cho H, Akoulitchev S, Reinberg D (1996). "Human cyclin-dependent kinase-activating kinase exists in three distinct complexes". Proc. Natl. Acad. Sci. U.S.A. 93 (13): 6488–93. Bibcode:1996PNAS...93.6488D. doi:10.1073/pnas.93.13.6488. PMC 39050. PMID 8692842.
  • Zhou Q, Sharp PA (1996). "Tat-SF1: cofactor for stimulation of transcriptional elongation by HIV-1 Tat". Science. 274 (5287): 605–10. Bibcode:1996Sci...274..605Z. doi:10.1126/science.274.5287.605. PMID 8849451. S2CID 13266489.
  • Parada CA, Roeder RG (1996). "Enhanced processivity of RNA polymerase II triggered by Tat-induced phosphorylation of its carboxy-terminal domain". Nature. 384 (6607): 375–8. Bibcode:1996Natur.384..375P. doi:10.1038/384375a0. PMID 8934526. S2CID 4278432.
  • García-Martínez LF, Ivanov D, Gaynor RB (1997). "Association of Tat with purified HIV-1 and HIV-2 transcription preinitiation complexes". J. Biol. Chem. 272 (11): 6951–8. doi:10.1074/jbc.272.11.6951. PMID 9054383.
  • Cujec TP, Cho H, Maldonado E, Meyer J, Reinberg D, Peterlin BM (1997). "The human immunodeficiency virus transactivator Tat interacts with the RNA polymerase II holoenzyme". Mol. Cell. Biol. 17 (4): 1817–23. doi:10.1128/mcb.17.4.1817. PMC 232028. PMID 9121429.
  • Rossignol M, Kolb-Cheynel I, Egly JM (1997). "Substrate specificity of the cdk-activating kinase (CAK) is altered upon association with TFIIH". EMBO J. 16 (7): 1628–37. doi:10.1093/emboj/16.7.1628. PMC 1169767. PMID 9130708.
  • Scully R, Anderson SF, Chao DM, Wei W, Ye L, Young RA, Livingston DM, Parvin JD (1997). "BRCA1 is a component of the RNA polymerase II holoenzyme". Proc. Natl. Acad. Sci. U.S.A. 94 (11): 5605–10. Bibcode:1997PNAS...94.5605S. doi:10.1073/pnas.94.11.5605. PMC 20825. PMID 9159119.
  • García-Martínez LF, Mavankal G, Neveu JM, Lane WS, Ivanov D, Gaynor RB (1997). "Purification of a Tat-associated kinase reveals a TFIIH complex that modulates HIV-1 transcription". EMBO J. 16 (10): 2836–50. doi:10.1093/emboj/16.10.2836. PMC 1169892. PMID 9184228.
  • Nekhai S, Shukla RR, Kumar A (1997). "A human primary T-lymphocyte-derived human immunodeficiency virus type 1 Tat-associated kinase phosphorylates the C-terminal domain of RNA polymerase II and induces CAK activity". J. Virol. 71 (10): 7436–41. doi:10.1128/JVI.71.10.7436-7441.1997. PMC 192089. PMID 9311822.
  • Cujec TP, Okamoto H, Fujinaga K, Meyer J, Chamberlin H, Morgan DO, Peterlin BM (1997). "The HIV transactivator TAT binds to the CDK-activating kinase and activates the phosphorylation of the carboxy-terminal domain of RNA polymerase II". Genes Dev. 11 (20): 2645–57. doi:10.1101/gad.11.20.2645. PMC 316603. PMID 9334327.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Li XY, Green MR (1998). "The HIV-1 Tat cellular coactivator Tat-SF1 is a general transcription elongation factor". Genes Dev. 12 (19): 2992–6. doi:10.1101/gad.12.19.2992. PMC 317190. PMID 9765201.
  • Ping YH, Rana TM (1999). "Tat-associated kinase (P-TEFb): a component of transcription preinitiation and elongation complexes". J. Biol. Chem. 274 (11): 7399–404. doi:10.1074/jbc.274.11.7399. PMID 10066804.

External links

  • v
  • t
  • e
(1) Basic domains
(1.1) Basic leucine zipper (bZIP)
(1.2) Basic helix-loop-helix (bHLH)
Group A
Group B
Group C
bHLH-PAS
Group D
Group E
Group F
bHLH-COE
(1.3) bHLH-ZIP
(1.4) NF-1
(1.5) RF-X
(1.6) Basic helix-span-helix (bHSH)
(2) Zinc finger DNA-binding domains
(2.1) Nuclear receptor (Cys4)
subfamily 1
subfamily 2
subfamily 3
subfamily 4
subfamily 5
subfamily 6
subfamily 0
(2.2) Other Cys4
(2.3) Cys2His2
(2.4) Cys6
(2.5) Alternating composition
(2.6) WRKY
(3) Helix-turn-helix domains
(3.1) Homeodomain
Antennapedia
ANTP class
protoHOX
Hox-like
metaHOX
NK-like
other
(3.2) Paired box
(3.3) Fork head / winged helix
(3.4) Heat shock factors
(3.5) Tryptophan clusters
(3.6) TEA domain
  • transcriptional enhancer factor
(4) β-Scaffold factors with minor groove contacts
(4.1) Rel homology region
(4.2) STAT
(4.3) p53-like
(4.4) MADS box
(4.6) TATA-binding proteins
(4.7) High-mobility group
(4.9) Grainyhead
(4.10) Cold-shock domain
(4.11) Runt
(0) Other transcription factors
(0.2) HMGI(Y)
(0.3) Pocket domain
(0.5) AP-2/EREBP-related factors
(0.6) Miscellaneous
see also transcription factor/coregulator deficiencies


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