Gadoxetic acid

Complex of gadolinium by a chelating agent derived from DTPA
  • V08CA10 (WHO)
Legal statusLegal status
  • US: ℞-only[1]
  • EU: Rx-only[2]
Identifiers
  • 2-[[2-[bis(2-oxido-2-oxoethyl)amino]-3-(4-ethoxyphenyl)propyl]-[2-[bis(2-oxido-2-oxoethyl)amino]ethyl]amino]acetate; gadolinium(+3) cation
CAS Number
  • 135326-11-3 checkY
PubChem CID
  • 131704314
DrugBank
  • DB08884 checkY
ChemSpider
  • 189907
UNII
  • 3QJA87N40S
KEGG
  • D08008 checkY
  • D04288
ChEMBL
  • ChEMBL1201768 ☒N
CompTox Dashboard (EPA)
  • DTXSID90928961 Edit this at Wikidata
Chemical and physical dataFormulaC23H30GdN3O11Molar mass681.75 g·mol−13D model (JSmol)
  • Interactive image
  • CCOc1ccc(cc1)C[C@@H](CN(CCN(CC(=O)O)CC(=O)[O-])CC(=O)[O-])N(CC(=O)O)CC(=O)[O-].[Gd+3]
InChI
  • InChI=1S/C23H33N3O11.Gd/c1-2-37-18-5-3-16(4-6-18)9-17(26(14-22(33)34)15-23(35)36)10-24(11-19(27)28)7-8-25(12-20(29)30)13-21(31)32;/h3-6,17H,2,7-15H2,1H3,(H,27,28)(H,29,30)(H,31,32)(H,33,34)(H,35,36);/q;+3/p-3/t17-;/m0./s1
  • Key:PCZHWPSNPWAQNF-LMOVPXPDSA-K
 ☒NcheckY (what is this?)  (verify)

Gadoxetic acid is a gadolinium-based MRI contrast agent.[3] Its salt, gadoxetate disodium, is marketed as Primovist in Europe and Eovist in the United States by Bayer HealthCare Pharmaceuticals.[1][4]

Medical uses

It is used to increase the T1 signal intensity while imaging the liver lesions such as benign cysts, hemangioma, and liver cancer. It is excreted into bile by active secretion.[5]

Pharmacokinetics

In those with end-stage renal failure, the clearance rate is only 17% with terminal half-life of 12 times longer than those with normal renal function.[5]

References

  1. ^ a b "Eovist- gadoxetate disodium injection, solution". DailyMed. National Library of Medicine, National Institutes of Health, U.S. Health & Human Services. Retrieved 21 April 2021.
  2. ^ "Active substance(s): gadoxetic acid disodium" (PDF). List of nationally authorised medicinal products. European Medicines Agency. 14 January 2021.
  3. ^ Koh DM, Ba-Ssalamah A, Brancatelli G, Fananapazir G, Fiel MI, Goshima S, et al. (August 2021). "Consensus report from the 9th International Forum for Liver Magnetic Resonance Imaging: applications of gadoxetic acid-enhanced imaging". European Radiology. 31 (8): 5615–5628. doi:10.1007/s00330-020-07637-4. PMC 8270799. PMID 33523304.
  4. ^ "Eovist - Homepage". Archived from the original on 2009-04-25. Retrieved 2009-03-22.
  5. ^ a b "Clinical pharmacology and biopharmaceutics review" (PDF). Center for drug evaluation and research. Archived from the original (PDF) on 12 May 2021. Retrieved 15 December 2022.
  • v
  • t
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Contrast media (V08)
X-ray and CT
Iodinated,
Water soluble
Nephrotropic,
high osmolar
Nephrotropic,
low osmolar
Hepatotropic
Iodinated,
Water insoluble
Non-iodinated
MRI
Paramagnetic
Superparamagnetic
Other
Ultrasound
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