Protein-coding gene in the species Homo sapiens
| GALR3 |
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| Identifiers |
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| Aliases | GALR3, Galanin receptor 3 |
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| External IDs | OMIM: 603692 MGI: 1329003 HomoloGene: 20798 GeneCards: GALR3 |
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| Gene location (Human) |
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 | | Chr. | Chromosome 22 (human)[1] |
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| | Band | 22q13.1 | Start | 37,823,382 bp[1] |
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| End | 37,825,485 bp[1] |
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| Gene location (Mouse) |
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 | | Chr. | Chromosome 15 (mouse)[2] |
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| | Band | 15 E1|15 37.7 cM | Start | 78,926,085 bp[2] |
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| End | 78,927,758 bp[2] |
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| RNA expression pattern |
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| Bgee | | Human | Mouse (ortholog) |
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| Top expressed in | - cerebellar hemisphere
- nucleus accumbens
- skeletal muscle tissue
- right lobe of liver
- body of pancreas
- putamen
- amygdala
- hypothalamus
- caudate nucleus
- Brodmann area 9
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| | Top expressed in | - intestinal villus
- yolk sac
- tracheobronchial tree
- inferior colliculus
- skin of abdomen
- islet of Langerhans
- stomach
- duodenum
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| | More reference expression data |
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| BioGPS |  | | More reference expression data |
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| Gene ontology |
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| Molecular function | - galanin receptor activity
- G protein-coupled receptor activity
- signal transducer activity
- peptide hormone binding
- G protein-coupled peptide receptor activity
| | Cellular component | - integral component of membrane
- plasma membrane
- integral component of plasma membrane
- membrane
- non-motile cilium
- cilium
| | Biological process | - learning or memory
- phospholipase C-activating G protein-coupled receptor signaling pathway
- neuropeptide signaling pathway
- feeding behavior
- positive regulation of transcription by RNA polymerase II
- signal transduction
- adenylate cyclase-modulating G protein-coupled receptor signaling pathway
- chemical synaptic transmission
- G protein-coupled receptor signaling pathway
- G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
- negative regulation of adenylate cyclase activity
- galanin-activated signaling pathway
| | Sources:Amigo / QuickGO |
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| Orthologs |
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| Species | Human | Mouse |
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| Entrez | | |
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| Ensembl | | |
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| UniProt | | |
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| RefSeq (mRNA) | | |
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| RefSeq (protein) | | |
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| Location (UCSC) | Chr 22: 37.82 – 37.83 Mb | Chr 15: 78.93 – 78.93 Mb |
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| PubMed search | [3] | [4] |
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| Wikidata |
| View/Edit Human | View/Edit Mouse |
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Galanin receptor 3 (GAL3) is a G-protein coupled receptor encoded by the GALR3 gene.[5]
Function
The neuropeptide galanin modulates a variety of physiologic processes including cognition/memory, sensory/pain processing, hormone secretion, and feeding behavior. The human galanin receptors are G protein-coupled receptors that functionally couple to their intracellular effector through distinct signaling pathways. GALR3 is found in many tissues and may be expressed as 1.4-, 2.4-, and 5-kb transcripts[5]
See also
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000128310 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000114755 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b "Entrez Gene: GALR3 galanin receptor 3".
Further reading
- Smith KE, Walker MW, Artymyshyn R, Bard J, Borowsky B, Tamm JA, Yao WJ, Vaysse PJ, Branchek TA, Gerald C, Jones KA (Sep 1998). "Cloned human and rat galanin GALR3 receptors. Pharmacology and activation of G-protein inwardly rectifying K+ channels". The Journal of Biological Chemistry. 273 (36): 23321–6. doi:10.1074/jbc.273.36.23321. PMID 9722565.
- Kolakowski LF, O'Neill GP, Howard AD, Broussard SR, Sullivan KA, Feighner SD, Sawzdargo M, Nguyen T, Kargman S, Shiao LL, Hreniuk DL, Tan CP, Evans J, Abramovitz M, Chateauneuf A, Coulombe N, Ng G, Johnson MP, Tharian A, Khoshbouei H, George SR, Smith RG, O'Dowd BF (Dec 1998). "Molecular characterization and expression of cloned human galanin receptors GALR2 and GALR3". Journal of Neurochemistry. 71 (6): 2239–51. doi:10.1046/j.1471-4159.1998.71062239.x. PMID 9832121. S2CID 1318986.
- Iismaa TP, Fathi Z, Hort YJ, Iben LG, Dutton JL, Baker E, Sutherland GR, Shine J (Dec 1998). "Structural organization and chromosomal localization of three human galanin receptor genes". Annals of the New York Academy of Sciences. 863 (1): 56–63. Bibcode:1998NYASA.863...56I. doi:10.1111/j.1749-6632.1998.tb10683.x. PMID 9928159. S2CID 42328897.
- Lapsys NM, Furler SM, Henderson NK, Dutton JL, Hort YJ, Eisman JA, Shine J, Iismaa TP (Aug 1999). "A polymorphism in the human GALR3 galanin receptor gene (GALNR3)". Molecular and Cellular Probes. 13 (4): 325–7. doi:10.1006/mcpr.1999.0254. PMID 10441207.
- Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP (Dec 1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi:10.1038/990031. PMID 10591208.
- Berger A, Tuechler C, Almer D, Kogner P, Ratschek M, Kerbl R, Iismaa TP, Jones N, Sperl W, Kofler B (Feb 2002). "Elevated expression of galanin receptors in childhood neuroblastic tumors". Neuroendocrinology. 75 (2): 130–8. doi:10.1159/000048229. PMID 11867941. S2CID 46848351.
- Belfer I, Hipp H, Bollettino A, McKnight C, Evans C, Virkkunen M, Albaugh B, Max MB, Goldman D, Enoch MA (Jul 2007). "Alcoholism is associated with GALR3 but not two other galanin receptor genes". Genes, Brain and Behavior. 6 (5): 473–81. doi:10.1111/j.1601-183X.2006.00275.x. PMID 17083333. S2CID 20809912.
- Runesson J, Sollenberg UE, Jurkowski W, Yazdi S, Eriksson EE, Elofsson A, Langel U (Dec 2010). "Determining receptor-ligand interaction of human galanin receptor type 3". Neurochemistry International. 57 (7): 804–11. doi:10.1016/j.neuint.2010.08.018. PMID 20817064. S2CID 18834008.
External links
- "Galanin Receptors: GAL3". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2019-10-26. Retrieved 2008-12-04.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
