Gastric inhibitory polypeptide receptor

Protein-coding gene in the species Homo sapiens
GIPR
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

4HJ0, 2QKH

Identifiers
AliasesGIPR, PGQTL2, gastric inhibitory polypeptide receptor
External IDsOMIM: 137241 MGI: 1352753 HomoloGene: 20081 GeneCards: GIPR
Gene location (Human)
Chromosome 19 (human)
Chr.Chromosome 19 (human)[1]
Chromosome 19 (human)
Genomic location for GIPR
Genomic location for GIPR
Band19q13.32Start45,668,221 bp[1]
End45,683,722 bp[1]
Gene location (Mouse)
Chromosome 7 (mouse)
Chr.Chromosome 7 (mouse)[2]
Chromosome 7 (mouse)
Genomic location for GIPR
Genomic location for GIPR
Band7|7 A3Start18,889,986 bp[2]
End18,900,052 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • right uterine tube

  • body of pancreas

  • body of stomach

  • islet of Langerhans

  • minor salivary glands

  • bronchial epithelial cell

  • tibia

  • left ventricle

  • rectum

  • subcutaneous adipose tissue
Top expressed in
  • islet of Langerhans

  • morula

  • spermatid

  • ganglionic eminence

  • left lung lobe

  • superior frontal gyrus

  • atrium

  • lens

  • stomach

  • testicle
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • G protein-coupled receptor activity
  • signal transducer activity
  • gastric inhibitory peptide receptor activity
  • transmembrane signaling receptor activity
  • protein binding
  • peptide hormone binding
  • G protein-coupled peptide receptor activity
Cellular component
  • integral component of membrane
  • membrane
  • plasma membrane
Biological process
  • response to fatty acid
  • response to nutrient
  • regulation of insulin secretion
  • positive regulation of cytosolic calcium ion concentration
  • response to glucose
  • generation of precursor metabolites and energy
  • activation of adenylate cyclase activity
  • response to calcium ion
  • cell surface receptor signaling pathway
  • gastric inhibitory peptide signaling pathway
  • response to axon injury
  • desensitization of G protein-coupled receptor signaling pathway
  • endocrine pancreas development
  • signal transduction
  • positive regulation of insulin secretion
  • G protein-coupled receptor signaling pathway
  • positive regulation of cAMP-mediated signaling
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

2696

381853

Ensembl

ENSG00000010310

ENSMUSG00000030406

UniProt

P48546

Q0P543

RefSeq (mRNA)

NM_000164
NM_001308418

NM_001080815

RefSeq (protein)

NP_000155
NP_001295347

NP_001074284

Location (UCSC)Chr 19: 45.67 – 45.68 MbChr 7: 18.89 – 18.9 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The gastric inhibitory polypeptide receptor (GIP-R), also known as the glucose-dependent insulinotropic polypeptide receptor, is a protein that in humans is encoded by the GIPR gene.[5][6]

GIP-R is a member of the class B family of G protein coupled receptors.[7] GIP-R is found on beta-cells in the pancreas[8][9] where it serves as the receptor for the hormone Gastric inhibitory polypeptide (GIP).

Function

Gastric inhibitory polypeptide, also called glucose-dependent insulinotropic polypeptide, is a 42-amino acid polypeptide synthesized by K cells of the duodenum and small intestine. It was originally identified as an activity in gut extracts that inhibited gastric acid secretion and gastrin release, but subsequently was demonstrated to stimulate insulin release potently in the presence of elevated glucose. The insulinotropic effect on pancreatic islet beta-cells was then recognized to be the principal physiologic action of GIP. Together with glucagon-like peptide-1, GIP is largely responsible for the secretion of insulin after eating. It is involved in several other facets of the anabolic response.[5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000010310 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030406 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: gastric inhibitory polypeptide receptor".
  6. ^ Stoffel M, Fernald AA, Le Beau MM, Bell GI (August 1995). "Assignment of the gastric inhibitory polypeptide receptor gene (GIPR) to chromosome bands 19q13.2-q13.3 by fluorescence in situ hybridization". Genomics. 28 (3): 607–609. doi:10.1006/geno.1995.1203. PMID 7490109.
  7. ^ NCBI, NCBI Gene entry 2696 (GIPR), retrieved 2018-12-20.
  8. ^ "Gastrointestinal Hormones and Peptides". Archived from the original on 2007-12-06. Retrieved 2007-08-24.
  9. ^ Brubaker PL, Drucker DJ (2002). "Structure-function of the glucagon receptor family of G protein-coupled receptors: the glucagon, GIP, GLP-1, and GLP-2 receptors". Recept. Channels. 8 (3–4): 179–188. doi:10.1080/10606820213687. PMID 12529935.

Further reading

  • Yamada Y, Seino Y (2005). "Physiology of GIP--a lesson from GIP receptor knockout mice". Horm. Metab. Res. 36 (11–12): 771–774. doi:10.1055/s-2004-826162. PMID 15655707. S2CID 262453421.
  • Gremlich S, Porret A, Hani EH, Cherif D, Vionnet N, Froguel P, Thorens B (1995). "Cloning, functional expression, and chromosomal localization of the human pancreatic islet glucose-dependent insulinotropic polypeptide receptor". Diabetes. 44 (10): 1202–1208. doi:10.2337/diabetes.44.10.1202. PMID 7556958.
  • Volz A, Göke R, Lankat-Buttgereit B, Fehmann HC, Bode HP, Göke B (1995). "Molecular cloning, functional expression, and signal transduction of the GIP-receptor cloned from a human insulinoma". FEBS Lett. 373 (1): 23–29. doi:10.1016/0014-5793(95)01006-Z. PMID 7589426. S2CID 25033358.
  • Usdin TB, Mezey E, Button DC, Brownstein MJ, Bonner TI (1994). "Gastric inhibitory polypeptide receptor, a member of the secretin-vasoactive intestinal peptide receptor family, is widely distributed in peripheral organs and the brain". Endocrinology. 133 (6): 2861–2870. doi:10.1210/endo.133.6.8243312. PMID 8243312.
  • Yamada Y, Hayami T, Nakamura K, Kaisaki PJ, Someya Y, Wang CZ, Seino S, Seino Y (1996). "Human gastric inhibitory polypeptide receptor: cloning of the gene (GIPR) and cDNA". Genomics. 29 (3): 773–776. doi:10.1006/geno.1995.9937. PMID 8575774.
  • Gallwitz B, Witt M, Morys-Wortmann C, Fölsch UR, Schmidt WE (1997). "GLP-1/GIP chimeric peptides define the structural requirements for specific ligand-receptor interaction of GLP-1". Regul. Pept. 63 (1): 17–22. doi:10.1016/0167-0115(96)00019-5. PMID 8795084. S2CID 42462407.
  • N'Diaye N, Tremblay J, Hamet P, De Herder WW, Lacroix A (1998). "Adrenocortical overexpression of gastric inhibitory polypeptide receptor underlies food-dependent Cushing's syndrome". J. Clin. Endocrinol. Metab. 83 (8): 2781–2785. doi:10.1210/jcem.83.8.5038. PMID 9709947.
  • Tseng CC, Zhang XY (2000). "Role of G protein-coupled receptor kinases in glucose-dependent insulinotropic polypeptide receptor signaling". Endocrinology. 141 (3): 947–952. doi:10.1210/endo.141.3.7365. PMID 10698169.
  • Bollag RJ, Zhong Q, Phillips P, Min L, Zhong L, Cameron R, Mulloy AL, Rasmussen H, Qin F (2000). "Osteoblast-derived cells express functional glucose-dependent insulinotropic peptide receptors". Endocrinology. 141 (3): 1228–1235. doi:10.1210/endo.141.3.7366. PMID 10698200.
  • Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Baldacchino V, Oble S, Hamet P, Tremblay J, Lacroix A (2003). "Partial characterisation of the 5' flanking region of the human GIP receptor (GIPR) gene". Endocr. Res. 28 (4): 577. doi:10.1081/ERC-120016843. PMID 12530665. S2CID 32639335.
  • Antonini SR, N'Diaye N, Hamet P, Tremblay J, Lacroix A (2003). "Analysis of the putative promoter region of the GIP receptor gene (GIPR) in GIP-dependent Cushing's syndrome (CS)". Endocr. Res. 28 (4): 755–756. doi:10.1081/ERC-120017003. PMID 12530694. S2CID 21467413.
  • Manhart S, Hinke SA, McIntosh CH, Pederson RA, Demuth HU (2003). "Structure-function analysis of a series of novel GIP analogues containing different helical length linkers". Biochemistry. 42 (10): 3081–3088. doi:10.1021/bi026868e. PMID 12627975.
  • Ding KH, Zhong Q, Isales CM (2003). "Glucose-dependent insulinotropic peptide stimulates thymidine incorporation in endothelial cells: role of endothelin-1". Am. J. Physiol. Endocrinol. Metab. 285 (2): E390–6. doi:10.1152/ajpendo.00509.2002. PMID 12721154.
  • Grimwood J, Gordon LA, Olsen A, Terry A, Schmutz J, Lamerdin J, Hellsten U, Goodstein D, Couronne O (2004). "The DNA sequence and biology of human chromosome 19". Nature. 428 (6982): 529–535. Bibcode:2004Natur.428..529G. doi:10.1038/nature02399. PMID 15057824.
  • Hansotia T, Baggio LL, Delmeire D, Hinke SA, Yamada Y, Tsukiyama K, Seino Y, Holst JJ, Schuit F (2004). "Double incretin receptor knockout (DIRKO) mice reveal an essential role for the enteroinsular axis in transducing the glucoregulatory actions of DPP-IV inhibitors". Diabetes. 53 (5): 1326–1335. doi:10.2337/diabetes.53.5.1326. PMID 15111503.
  • Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Baldacchino V, Oble S, Hamet P, Tremblay J, Bourdeau I, Lacroix A (2005). "The Sp transcription factor family is involved in the cellular expression of the human GIP-R gene promoter". Endocr. Res. 30 (4): 805–806. doi:10.1081/ERC-200044046. PMID 15666829. S2CID 40407171.

External links

  • "Glucagon Receptor Family: GIP". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2016-03-03. Retrieved 2007-10-25.
  • gastric+inhibitory+polypeptide+receptor at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.