HECW1

Protein-coding gene in the species Homo sapiens

HECW1

Available structures

PDB

Ortholog search: PDBe RCSB

List of PDB id codes
3L4H

Identifiers

Aliases

HECW1, NEDL1, HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1

External IDs

OMIM: 610384; MGI: 2444115; HomoloGene: 9004; GeneCards: HECW1; OMA:HECW1 - orthologs

Gene location (Human)

Chr.	Chromosome 7 (human)^[1]

Band	7p14.1-p13	Start	43,112,629 bp^[1]
Band	7p14.1-p13	End	43,566,001 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 13 (mouse)^[2]

Band	13 A1\|13 5.29 cM	Start	14,401,023 bp^[2]
Band	13 A1\|13 5.29 cM	End	14,697,813 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

Brodmann area 23

middle temporal gyrus

endothelial cell

ganglionic eminence

prefrontal cortex

dorsolateral prefrontal cortex

superior frontal gyrus

pons

Brodmann area 9

parietal lobe

Top expressed in

medial dorsal nucleus

facial motor nucleus

primary motor cortex

anterior horn of spinal cord

medial geniculate nucleus

medial vestibular nucleus

prefrontal cortex

trigeminal ganglion

lateral geniculate nucleus

spinal ganglia

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	transferase activity ubiquitin-protein transferase activity ubiquitin protein ligase activity
Cellular component	cytosol cytoplasm
Biological process	negative regulation of canonical Wnt signaling pathway protein ubiquitination proteasome-mediated ubiquitin-dependent protein catabolic process protein polyubiquitination ubiquitin-dependent protein catabolic process positive regulation of protein catabolic process regulation of dendrite morphogenesis negative regulation of sodium ion transmembrane transporter activity
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


23072


94253

Ensembl


ENSG00000002746


ENSMUSG00000021301

UniProt


Q76N89


Q8K4P8

RefSeq (mRNA)


NM_001287059 NM_015052


NM_001081348 NM_153130 NM_178809

RefSeq (protein)


NP_001273988 NP_055867


NP_001074817

Location (UCSC)

Chr 7: 43.11 – 43.57 Mb

Chr 13: 14.4 – 14.7 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1 is a protein that in humans is encoded by the HECW1 gene.^[5] In human it has 1606 amino acids (179.5 kDa) and isoelectric point of 5.18.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000002746 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000021301 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1".
^ Kozlowski LP (October 2016). "IPC - Isoelectric Point Calculator". Biology Direct. 11 (1): 55. doi:10.1186/s13062-016-0159-9. PMC 5075173. PMID 27769290.

Miyazaki K, Fujita T, Ozaki T, Kato C, Kurose Y, Sakamoto M, Kato S, Goto T, Itoyama Y, Aoki M, Nakagawara A (March 2004). "NEDL1, a novel ubiquitin-protein isopeptide ligase for dishevelled-1, targets mutant superoxide dismutase-1". The Journal of Biological Chemistry. 279 (12): 11327–35. doi:10.1074/jbc.M312389200. PMID 14684739.
Chansard M, Wang J, Tran HC, Neumayer G, Shim SY, Park YU, Belzil C, Le HT, Park SK, Nguyen MD (January 2011). "The cytoskeletal protein Ndel1 regulates dynamin 2 GTPase activity". PLOS ONE. 6 (1): e14583. Bibcode:2011PLoSO...614583C. doi:10.1371/journal.pone.0014583. PMC 3026782. PMID 21283621.
Sherva R, Tripodis Y, Bennett DA, Chibnik LB, Crane PK, de Jager PL, Farrer LA, Saykin AJ, Shulman JM, Naj A, Green RC (January 2014). "Genome-wide association study of the rate of cognitive decline in Alzheimer's disease". Alzheimer's & Dementia. 10 (1): 45–52. doi:10.1016/j.jalz.2013.01.008. PMC 3760995. PMID 23535033.
Li Y, Ozaki T, Kikuchi H, Yamamoto H, Ohira M, Nakagawara A (June 2008). "A novel HECT-type E3 ubiquitin protein ligase NEDL1 enhances the p53-mediated apoptotic cell death in its catalytic activity-independent manner". Oncogene. 27 (26): 3700–9. doi:10.1038/sj.onc.1211032. PMID 18223681.
Harvey KF, Dinudom A, Cook DI, Kumar S (March 2001). "The Nedd4-like protein KIAA0439 is a potential regulator of the epithelial sodium channel". The Journal of Biological Chemistry. 276 (11): 8597–601. doi:10.1074/jbc.C000906200. PMID 11244092.
Zhang L, Haraguchi S, Koda T, Hashimoto K, Nakagawara A (2011). "Muscle atrophy and motor neuron degeneration in human NEDL1 transgenic mice". Journal of Biomedicine & Biotechnology. 2011: 1–7. doi:10.1155/2011/831092. PMC 2952905. PMID 20976258.
Cui Y, He S, Xing C, Lu K, Wang J, Xing G, Meng A, Jia S, He F, Zhang L (May 2011). "SCFFBXL¹⁵ regulates BMP signalling by directing the degradation of HECT-type ubiquitin ligase Smurf1". The EMBO Journal. 30 (13): 2675–89. doi:10.1038/emboj.2011.155. PMC 3155294. PMID 21572392.
Shinada K, Tsukiyama T, Sho T, Okumura F, Asaka M, Hatakeyama S (January 2011). "RNF43 interacts with NEDL1 and regulates p53-mediated transcription". Biochemical and Biophysical Research Communications. 404 (1): 143–7. doi:10.1016/j.bbrc.2010.11.082. hdl:2115/44929. PMID 21108931. S2CID 8665279.
Levine DM, Ek WE, Zhang R, Liu X, Onstad L, Sather C, Lao-Sirieix P, Gammon MD, Corley DA, Shaheen NJ, Bird NC, Hardie LJ, Murray LJ, Reid BJ, Chow WH, Risch HA, Nyrén O, Ye W, Liu G, Romero Y, Bernstein L, Wu AH, Casson AG, Chanock SJ, Harrington P, Caldas I, Debiram-Beecham I, Caldas C, Hayward NK, Pharoah PD, Fitzgerald RC, Macgregor S, Whiteman DC, Vaughan TL (December 2013). "A genome-wide association study identifies new susceptibility loci for esophageal adenocarcinoma and Barrett's esophagus". Nature Genetics. 45 (12): 1487–93. doi:10.1038/ng.2796. PMC 3840115. PMID 24121790.