HES3

Protein-coding gene in the species Homo sapiens
HES3
Identifiers
AliasesHES3, bHLHb43, hes family bHLH transcription factor 3
External IDsOMIM: 609971 MGI: 104877 HomoloGene: 7358 GeneCards: HES3
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for HES3
Genomic location for HES3
Band1p36.31Start6,244,179 bp[1]
End6,245,578 bp[1]
Gene location (Mouse)
Chromosome 4 (mouse)
Chr.Chromosome 4 (mouse)[2]
Chromosome 4 (mouse)
Genomic location for HES3
Genomic location for HES3
Band4 E2|4 83.01 cMStart152,370,429 bp[2]
End152,376,119 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • testicle

  • blood

  • multicellular organism
Top expressed in
  • urethra

  • male urethra

  • female urethra

  • cerebellar cortex

  • Purkinje cell

  • adrenal medulla

  • pars intermedia

  • tongue

  • pharynx

  • cranial nervi
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • DNA binding
  • transcription factor binding
  • protein dimerization activity
  • RNA polymerase II cis-regulatory region sequence-specific DNA binding
  • DNA-binding transcription repressor activity, RNA polymerase II-specific
  • DNA-binding transcription factor activity, RNA polymerase II-specific
  • RNA polymerase II transcription regulatory region sequence-specific DNA binding
  • transcription corepressor activity
  • sequence-specific DNA binding
  • sequence-specific double-stranded DNA binding
Cellular component
  • nucleus
Biological process
  • hindbrain morphogenesis
  • trochlear nerve development
  • midbrain-hindbrain boundary morphogenesis
  • negative regulation of transcription, DNA-templated
  • in utero embryonic development
  • negative regulation of transcription by RNA polymerase II
  • regulation of transcription, DNA-templated
  • regulation of timing of neuron differentiation
  • regulation of neurogenesis
  • oculomotor nerve development
  • transcription, DNA-templated
  • midbrain development
  • positive regulation of transcription by RNA polymerase II
  • neural tube development
  • somitogenesis
  • Notch signaling pathway
  • cell differentiation
  • anterior/posterior pattern specification
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

390992

15207

Ensembl

ENSG00000173673

ENSMUSG00000028946

UniProt

Q5TGS1

Q61657

RefSeq (mRNA)

NM_001024598

NM_008237

RefSeq (protein)

NP_001019769

NP_032263
NP_001390720
NP_001390721
NP_001390722
NP_001390723

Location (UCSC)Chr 1: 6.24 – 6.25 MbChr 4: 152.37 – 152.38 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Hes family bHLH transcription factor 3 is a protein that in humans is encoded by the HES3 gene.[5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000173673 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028946 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Hes family bHLH transcription factor 3".

Further reading

  • Katoh M, Katoh M (August 2004). "Identification and characterization of human HES2, HES3, and HES5 genes in silico". International Journal of Oncology. 25 (2): 529–34. doi:10.3892/ijo.25.2.529. PMID 15254753.
  • Katoh M, Katoh M (August 2007). "Integrative genomic analyses on HES/HEY family: Notch-independent HES1, HES3 transcription in undifferentiated ES cells, and Notch-dependent HES1, HES5, HEY1, HEY2, HEYL transcription in fetal tissues, adult tissues, or cancer". International Journal of Oncology. 31 (2): 461–6. doi:10.3892/ijo.31.2.461. PMID 17611704.
  • Fukami M, Wada Y, Okada M, Kato F, Katsumata N, Baba T, Morohashi K, Laporte J, Kitagawa M, Ogata T (February 2008). "Mastermind-like domain-containing 1 (MAMLD1 or CXorf6) transactivates the Hes3 promoter, augments testosterone production, and contains the SF1 target sequence". The Journal of Biological Chemistry. 283 (9): 5525–32. doi:10.1074/jbc.M703289200. PMID 18162467.
  • Park DM, Jung J, Masjkur J, Makrogkikas S, Ebermann D, Saha S, Rogliano R, Paolillo N, Pacioni S, McKay RD, Poser S, Androutsellis-Theotokis A (2013). "Hes3 regulates cell number in cultures from glioblastoma multiforme with stem cell characteristics". Scientific Reports. 3: 1095. Bibcode:2013NatSR...3E1095P. doi:10.1038/srep01095. PMC 3566603. PMID 23393614.
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(1) Basic domains
(1.1) Basic leucine zipper (bZIP)
(1.2) Basic helix-loop-helix (bHLH)
Group A
Group B
Group C
bHLH-PAS
Group D
Group E
Group F
bHLH-COE
(1.3) bHLH-ZIP
(1.4) NF-1
(1.5) RF-X
(1.6) Basic helix-span-helix (bHSH)
(2) Zinc finger DNA-binding domains
(2.1) Nuclear receptor (Cys4)
subfamily 1
subfamily 2
subfamily 3
subfamily 4
subfamily 5
subfamily 6
subfamily 0
(2.2) Other Cys4
(2.3) Cys2His2
(2.4) Cys6
(2.5) Alternating composition
(2.6) WRKY
(3) Helix-turn-helix domains
(3.1) Homeodomain
Antennapedia
ANTP class
protoHOX
Hox-like
metaHOX
NK-like
other
(3.2) Paired box
(3.3) Fork head / winged helix
(3.4) Heat shock factors
(3.5) Tryptophan clusters
(3.6) TEA domain
  • transcriptional enhancer factor
(4) β-Scaffold factors with minor groove contacts
(4.1) Rel homology region
(4.2) STAT
(4.3) p53-like
(4.4) MADS box
(4.6) TATA-binding proteins
(4.7) High-mobility group
(4.9) Grainyhead
(4.10) Cold-shock domain
(4.11) Runt
(0) Other transcription factors
(0.2) HMGI(Y)
(0.3) Pocket domain
(0.5) AP-2/EREBP-related factors
(0.6) Miscellaneous
see also transcription factor/coregulator deficiencies