Human leukocyte antigen serotype
|
HLA-B62 with bound peptide |
major histocompatibility complex (human), class I, B62 |
Alleles | *1501, *1504, *1507, *1525 |
Structure (See HLA-B) |
Shared data |
Locus | chr.6 6p21.31 |
HLA-B62 (B62) is an HLA-B serotype. The serotype identifies certain B*15 gene-allele protein products of HLA-B.[1]
B62 is the largest of many split antigens of the broad antigen, B15. B62 best identifies the B*1501, B*1504, B*1507 B*1525 and B*1533 allele products.
Serotype
Serotypes B15, B62, B63, B70, B71, B72, B75, B76, B77
recognition of the HLA B*15 gene products[2] B*15 | B15 | B62 | B63 | B70 | B71 | B72 | B75 | B76 | B77 | Sample |
allele | % | % | % | % | % | % | % | % | % | size (N) |
*1501 | 2 | 96 | | | | | | | | 1906 |
*1504 | 10 | 69 | | | | | | | | 29 |
*1505 | 18 | 64 | | | | | | | | 22 |
*1506 | | 40 | | 20 | | | 11 | | | 10 |
*1507 | | 79 | | | | | | | | 101 |
*1508 | | 20 | | | | | 18 | | | 45 |
*1511 | 15 | 27 | | | | | 21 | | | 68 |
*1512 | 17 | 18 | | | | | | 8 | | 12 |
*1515 | 13 | 49 | | | | | 28 | | | 138 |
*1520 | | 100 | | | | | | | | 5 |
*1524 | | 44 | | | | | | | | 54 |
*1525 | 7 | 74 | | | | | 8 | | | 116 |
*1527 | 7 | 76 | | | | | | | | 76 |
*1528 | 14 | 57 | | | | | 14 | | | 7 |
*1530 | 17 | 64 | | | | | | | | 98 |
*1531 | | 50 | | | | | | | | 12 |
*1535 | | 79 | | | | | | | | 34 |
Allele | B15 | B62 | B63 | B70 | B71 | B72 | B75 | B76 | B77 | N |
Alleles link-out to IMGT/HLA Databease at EBI |
Alleles
HLA B*1501 frequencies | | freq |
ref. | Population | (%) |
[3] | Japan Ainu Hokkaido | 29.0 |
| Chihuahuan Tarahumara | 14.8 |
| Autonomous Tibetans | 12.3 |
| South Korea ( 3) | 10.5 |
| Japan Central | 8.7 |
| Japan pop3 | 7.5 |
| USA North American Natives | 7.2 |
| South Dakota Lakota Sioux | 7.1 |
| Shijiazhuang Tianjian Han | 7.0 |
| China Qinghai Hui | 6.8 |
| Croatia | 6.7 |
| Japan pop5 | 6.5 |
| Portugal Centre | 6.0 |
| Taiwan Rukai | 6.0 |
| USA Alaska Yupik Natives | 5.8 |
| Australia New South Wales | 5.6 |
| USA European Americans (2) | 5.6 |
| France South East | 5.5 |
| China Beijing | 5.3 |
| Czech Republic | 4.7 |
| Ireland South | 4.6 |
| Mexico Sonora Seri | 4.5 |
| China Inner Mongolia | 4.4 |
| Russia Tuva (2) | 4.2 |
| Singapore Chinese | 4.0 |
| Taiwan Paiwan | 3.9 |
| China North Han | 3.8 |
| Georgia Svaneti Svans | 3.8 |
| Ireland Northern | 3.8 |
| Italy North Pavia | 3.7 |
| Mexico Mestizos | 3.7 |
| Azores Central Islands | 3.6 |
| Madeira | 3.5 |
| Taiwan Minnan pop 1 | 3.4 |
| Azores Terceira Island | 3.1 |
| Taiwan Siraya | 2.9 |
| USA Hispanic | 2.8 |
| Taiwan Hakka | 2.7 |
| Taiwan Pazeh | 2.7 |
| China Yunnan Nu | 2.6 |
| Uganda Kampala | 2.5 |
| Argentina Toba Rosario | 2.3 |
| Romanian | 2.3 |
| Hong Kong Chinese | 2.2 |
| India North Hindus | 1.9 |
| New Caledonia | 1.9 |
| Italy South Campania | 1.8 |
| Taiwan Thao | 1.7 |
| India North Delhi | 1.6 |
| China Guangzhou | 1.5 |
| China Guangxi Maonan | 1.4 |
| China Yunnan Lisu | 1.4 |
| Thailand | 1.4 |
| PNG New Britain Rabaul | 1.3 |
| Brazil Belo Horizonte | 1.1 |
| Cameroon Yaounde | 1.1 |
| Portugal North | 1.1 |
| United Arab Emerates | 1.1 |
| Thailand pop3 | 1.0 |
| USA African America | 1.0 |
| USA African Americans | 1.0 |
| Indig. Australian Yuendumu | 0.8 |
| PNG Wanigela | 0.8 |
| Mexico Zaptotec Oaxaca | 0.7 |
| Spain Eastern Andalusia | 0.6 |
| South African Natal Zulu | 0.5 |
| Spain E. Andalusia Gipsy | 0.5 |
| Sudanese | 0.5 |
| Taiwan Bunun | 0.5 |
HLA B*1515 frequencies | | freq |
ref. | Population | (%) |
[3] | Mexico Mestizos | 2.4 |
| Mex. Guadalajara Mestizos (2) | 1.9 |
| Argentina Toba Rosario | 1.2 |
| China Guangdong Meizhou Han | 1.0 |
| China North Han | 1.0 |
| Cape Verde NW Islands | 0.8 |
| USA South Texas Hispanics | 0.8 |
| USA San Antonio Caucasians | 0.6 |
| USA Hispanic | 0.4 |
| USA Asian | 0.3 |
| USA North American Natives | 0.3 |
| USA African America | 0.2 |
| Hong Kong Chinese | 0.1 |
HLA B*1525 frequencies | | freq |
ref. | Population | (%) |
[3] | Taiwan Tao | 40.0 |
| Taiwan Thao | 11.7 |
| Taiwan Pazeh | 10.9 |
| China Yunnan Lisu | 8.7 |
| China Yunnan Nu | 8.3 |
| PNG West Schrader Ranges | 8.2 |
| Indig. Australian Groote Eylandt | 8.0 |
| Taiwan Puyuma | 7.0 |
| Taiwan Rukai | 7.0 |
| Taiwan Bunun | 6.4 |
| Indig. Australian Yuendumu | 5.7 |
| Taiwan Siraya | 4.9 |
| Taiwan Tsou | 4.9 |
| Philippines Ivatan | 3.0 |
| Taiwan Atayal | 2.8 |
| Taiwan Ami | 2.6 |
| Thailand | 2.5 |
| China Guangzhou | 2.0 |
| Thailand pop3 | 2.0 |
| Hong Kong Chinese | 1.9 |
| PNG Wanigela | 1.5 |
| PNG Wosera | 1.5 |
| Singapore Thai | 1.5 |
| India Andhra Pradesh Golla | 1.4 |
| PNG Eastern Highlands Goroka | 1.4 |
| China South Han | 1.1 |
| China Inner Mongolia | 1.0 |
| India North Hindus | 1.0 |
HLA B*1507 frequencies | | freq |
ref. | Population | (%) |
[3] | Argentina Toba Rosario | 8.1 |
| New Mexico Canoncito Navajo | 3.7 |
| Brazil Terena | 2.6 |
| USA North American Natives | 0.8 |
| Japan Central | 0.7 |
| South Korea pop 3 | 0.6 |
| Japan pop3 | 0.4 |
| USA Asian | 0.4 |
| Shijiazhuang Tianjian Han | 0.3 |
| USA Caucasian pop2 | 0.2 |
| Hong Kong Chinese | 0.1 |
| Ireland Northern | 0.1 |
References
- ^ Marsh, S. G.; Albert, E. D.; Bodmer, W. F.; Bontrop, R. E.; Dupont, B.; Erlich, H. A.; Fernández-Viña, M.; Geraghty, D. E.; Holdsworth, R.; Hurley, C. K.; Lau, M.; Lee, K. W.; Mach, B.; Maiers, M.; Mayr, W. R.; Müller, C. R.; Parham, P.; Petersdorf, E. W.; Sasazuki, T.; Strominger, J. L.; Svejgaard, A.; Terasaki, P. I.; Tiercy, J. M.; Trowsdale, J. (2010). "Nomenclature for factors of the HLA system, 2010". Tissue Antigens. 75 (4): 291–455. doi:10.1111/j.1399-0039.2010.01466.x. PMC 2848993. PMID 20356336.
- ^ derived from IMGT/HLA
- ^ a b c d Middleton D, Menchaca L, Rood H, Komerofsky R (2003). "New allele frequency database". Tissue Antigens. 61 (5): 403–7. doi:10.1034/j.1399-0039.2003.00062.x. PMID 12753660.
HLA-B serotypes and allele groups
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