HMGB3

Protein-coding gene in the species Homo sapiens
HMGB3
Available structures
PDBHuman UniProt search: PDBe RCSB
List of PDB id codes

2EQZ, 2YQI

Identifiers
AliasesHMGB3, HMG-2a, HMG-4, HMG2A, HMG4, high mobility group box 3
External IDsOMIM: 300193 HomoloGene: 84734 GeneCards: HMGB3
Gene location (Human)
X chromosome (human)
Chr.X chromosome (human)[1]
X chromosome (human)
Genomic location for HMGB3
Genomic location for HMGB3
BandXq28Start150,980,509 bp[1]
End150,990,771 bp[1]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • secondary oocyte

  • ganglionic eminence

  • placenta

  • islet of Langerhans

  • right lobe of liver

  • sural nerve

  • rectum

  • gastrocnemius muscle

  • bone marrow

  • minor salivary glands
    n/a
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • DNA binding
  • double-stranded DNA binding
  • DNA binding, bending
  • protein binding
  • four-way junction DNA binding
  • RNA binding
  • transcription factor binding
Cellular component
  • cytoplasm
  • nucleus
  • chromosome
Biological process
  • multicellular organism development
  • immune system process
  • DNA recombination
  • innate immune response
  • regulation of transcription, DNA-templated
  • transcription, DNA-templated
  • DNA geometric change
  • negative regulation of B cell differentiation
  • negative regulation of myeloid cell differentiation
  • chromatin remodeling
  • regulation of transcription by RNA polymerase II
  • positive regulation of innate immune response
  • positive regulation of transcription by RNA polymerase II
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

3149

n/a

Ensembl

ENSG00000029993

n/a

UniProt

O15347

n/a

RefSeq (mRNA)

NM_005342
NM_001301228
NM_001301229
NM_001301231

n/a

RefSeq (protein)

NP_001288157
NP_001288158
NP_001288160
NP_005333

n/a

Location (UCSC)Chr X: 150.98 – 150.99 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

High-mobility group protein B3 is a protein that in humans is encoded by the HMGB3 gene.[3][4]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000029993 – Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ Vaccari T, Beltrame M, Ferrari S, Bianchi ME (April 1998). "Hmg4, a new member of the Hmg1/2 gene family". Genomics. 49 (2): 247–52. doi:10.1006/geno.1998.5214. PMID 9598312.
  4. ^ "Entrez Gene: HMGB3 high-mobility group box 3".

Further reading

  • Davis DL, Burch JB (April 1992). "Isolation of a chicken HMG2 cDNA clone and evidence for an HMG2-specific 3'-untranslated region". Gene. 113 (2): 251–6. doi:10.1016/0378-1119(92)90403-C. PMID 1572546.
  • Shirakawa H, Tsuda K, Yoshida M (May 1990). "Primary structure of non-histone chromosomal protein HMG2 revealed by the nucleotide sequence". Biochemistry. 29 (18): 4419–23. doi:10.1021/bi00470a022. PMID 2350545.
  • Wilke K, Wiemann S, Gaul R, Gong W, Poustka A (October 1997). "Isolation of human and mouse HMG2a cDNAs: evidence for an HMG2a-specific 3' untranslated region". Gene. 198 (1–2): 269–74. doi:10.1016/S0378-1119(97)00324-7. PMID 9370291.
  • Hartley JL, Temple GF, Brasch MA (November 2000). "DNA cloning using in vitro site-specific recombination". Genome Research. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
  • Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A (October 2004). "From ORFeome to biology: a functional genomics pipeline". Genome Research. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
  • Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S (January 2006). "The LIFEdb database in 2006". Nucleic Acids Research. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.

External links

  • HMGB3+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
  • PDBe-KB provides an overview of all the structure information available in the PDB for Human High mobility group protein B3 (HMGB3)
  • v
  • t
  • e
(1) Basic domains
(1.1) Basic leucine zipper (bZIP)
(1.2) Basic helix-loop-helix (bHLH)
Group A
Group B
Group C
bHLH-PAS
Group D
Group E
Group F
bHLH-COE
(1.3) bHLH-ZIP
(1.4) NF-1
(1.5) RF-X
(1.6) Basic helix-span-helix (bHSH)
(2) Zinc finger DNA-binding domains
(2.1) Nuclear receptor (Cys4)
subfamily 1
subfamily 2
subfamily 3
subfamily 4
subfamily 5
subfamily 6
subfamily 0
(2.2) Other Cys4
(2.3) Cys2His2
(2.4) Cys6
(2.5) Alternating composition
(2.6) WRKY
(3) Helix-turn-helix domains
(3.1) Homeodomain
Antennapedia
ANTP class
protoHOX
Hox-like
metaHOX
NK-like
other
(3.2) Paired box
(3.3) Fork head / winged helix
(3.4) Heat shock factors
(3.5) Tryptophan clusters
(3.6) TEA domain
  • transcriptional enhancer factor
(4) β-Scaffold factors with minor groove contacts
(4.1) Rel homology region
(4.2) STAT
(4.3) p53-like
(4.4) MADS box
(4.6) TATA-binding proteins
(4.7) High-mobility group
(4.9) Grainyhead
(4.10) Cold-shock domain
(4.11) Runt
(0) Other transcription factors
(0.2) HMGI(Y)
(0.3) Pocket domain
(0.5) AP-2/EREBP-related factors
(0.6) Miscellaneous
see also transcription factor/coregulator deficiencies
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