HMGN3

Protein-coding gene in the species Homo sapiens
HMGN3
Identifiers
AliasesHMGN3, PNAS-25, TRIP7, PNAS-24, high mobility group nucleosomal binding domain 3
External IDsOMIM: 604502 HomoloGene: 130417 GeneCards: HMGN3
Gene location (Human)
Chromosome 6 (human)
Chr.Chromosome 6 (human)[1]
Chromosome 6 (human)
Genomic location for HMGN3
Genomic location for HMGN3
Band6q14.1Start79,201,245 bp[1]
End79,234,738 bp[1]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • bronchial epithelial cell

  • endothelial cell

  • palpebral conjunctiva

  • right uterine tube

  • parietal pleura

  • visceral pleura

  • hair follicle

  • germinal epithelium

  • glomerulus

  • metanephric glomerulus
    n/a
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • nucleosomal DNA binding
  • DNA binding
  • chromatin binding
  • thyroid hormone receptor binding
Cellular component
  • chromatin
  • nucleus
  • nucleoplasm
  • cytosol
Biological process
  • regulation of insulin secretion involved in cellular response to glucose stimulus
  • positive regulation of transcription by RNA polymerase II
  • biological process
  • chromatin organization
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

9324

n/a

Ensembl

ENSG00000118418

n/a

UniProt

Q15651

n/a

RefSeq (mRNA)
NM_001201362
NM_001201363
NM_004242
NM_138730
NM_001318884

NM_001318885
NM_001318886
NM_001318887
NM_001318888

n/a

RefSeq (protein)
NP_001188291
NP_001188292
NP_001305813
NP_001305814
NP_001305815

NP_001305816
NP_001305817
NP_004233
NP_620058

n/a

Location (UCSC)Chr 6: 79.2 – 79.23 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

High mobility group nucleosome-binding domain-containing protein 3 is a protein that in humans is encoded by the HMGN3 gene.[3][4][5]

Thyroid hormone receptors are hormone-dependent transcription factors that regulate expression of a variety of specific target genes. The protein encoded by this gene binds thyroid hormone receptor beta, but only in the presence of thyroid hormone. The encoded protein, a member of the HMGN protein family, is thought to reduce the compactness of the chromatin fiber in nucleosomes, thereby enhancing transcription from chromatin templates. Two transcript variants encoding different isoforms have been found for this gene.[5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000118418 – Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ Lee JW, Choi HS, Gyuris J, Brent R, Moore DD (Jul 1995). "Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor". Mol Endocrinol. 9 (2): 243–54. doi:10.1210/mend.9.2.7776974. PMID 7776974.
  4. ^ West KL, Ito Y, Birger Y, Postnikov Y, Shirakawa H, Bustin M (Jul 2001). "HMGN3a and HMGN3b, two protein isoforms with a tissue-specific expression pattern, expand the cellular repertoire of nucleosome-binding proteins". J Biol Chem. 276 (28): 25959–69. doi:10.1074/jbc.M101692200. PMID 11356838.
  5. ^ a b "Entrez Gene: HMGN3 high mobility group nucleosomal binding domain 3".

Further reading

  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Leong PW, Liew K, Lim W, Chow VT (2002). "Differential display RT-PCR analysis of enterovirus-71-infected rhabdomyosarcoma cells reveals mRNA expression responses of multiple human genes with known and novel functions". Virology. 295 (1): 147–59. doi:10.1006/viro.2002.1353. PMID 12033773.

External links


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